Preparation method of mequindox
A technology of acemequine and eggshell, applied in the field of preparation of acemequine, can solve the problems of strong soda ash activity, poor catalytic effect, complicated steps and the like, and achieves the effects of low cost, reduced production process and improved production efficiency
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0024] The invention provides a kind of preparation method of acemetquine, comprising the following steps:
[0025] Mix o-nitroaniline, oxidant, dispersant, catalyst and alcohol solvent for oxidation reaction to obtain benzofurazan product feed liquid;
[0026] Mixing the benzofurazan product liquid and acetylacetone for condensation reaction to obtain acetylmethaquine;
[0027] Wherein, the catalyst is a KOH / eggshell composite; the KOH / eggshell composite includes eggshell powder and KOH loaded on the eggshell powder.
[0028] In the present invention, the synthetic route of described acemetquine is shown in formula A:
[0029]
[0030] The formula A will be specifically described below.
[0031] In the invention, o-nitroaniline, oxidant, dispersant, catalyst and alcohol solvent are mixed for oxidation reaction to obtain benzofurazan product material liquid. In the present invention, the oxidant preferably includes one or more of hydrogen peroxide, sodium hypochlorite, p...
Embodiment 1
[0053] Add 2g of pigeon eggshell powder to 20mL of 3mol / L KOH solution, and stir at room temperature for 1h. Then the solution was filtered, the filtrate was removed, and the powder was dried in an oven at 60° C. for 2 hours to obtain a KOH / eggshell complex.
[0054] Add 5g o-nitroaniline, 40mL ethanol, 1.5g KOH / eggshell complex, 0.25g sodium alginate into the reactor, heat to 30°C, stir until dissolved, then slowly add 5g hydrogen peroxide (mass fraction is 30 %), the temperature was controlled at 30° C., the dropwise addition was completed in 0.5 h, and the reaction was continued for 1 h to obtain the benzofurazan product feed liquid.
[0055] Add 4.8 g of acetylacetone to the benzofurazan product liquid, stir to dissolve, react at 45°C for 8 hours, a yellow solid appears, stop the reaction, place at 4°C for 5 hours, a large amount of solids precipitate out. Filtrate to remove the filtrate, dissolve the solid in acetone (mass volume ratio is 1g:1mL), filter again to remove ...
Embodiment 2
[0058] Add 6g of duck egg shell powder into 60mL of 4mol / L KOH solution, and stir at room temperature for 0.5h. Then the solution was filtered, the filtrate was removed, and the powder was dried in an oven at 60° C. for 1 h to obtain a KOH / eggshell complex.
[0059] Add 10g o-nitroaniline, 80mL ethanol, 4g KOH / eggshell complex, 0.6g sodium carboxymethylcellulose into the reactor, heat to 35°C, stir until dissolved, then slowly add 8g sodium hypochlorite to it, and control the temperature At 35° C., the dropwise addition was completed for 1 h, and the reaction was continued for 1 h to obtain a benzofurazan product liquid.
[0060] Add 11g of acetylacetone to the benzofurazan product liquid, stir to dissolve, react at 50°C for 9h, a yellow solid appears, stop the reaction, place at 4°C for 6h, a large amount of solids are precipitated. Filtrate, remove the filtrate, dissolve the solid in chloroform solution (mass volume ratio is 1g:1mL), filter again, remove the insoluble solid...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com