Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism

A technology of vascular embolism and gelatin, which is applied in the field of preparation of injectable gelatin-iodol homogeneous preparations for vascular embolism, can solve the problems of inability to improve the loss and loss of lipiodol, incomplete tumor embolization, tumor recurrence, etc., and achieve embolism-enhancing drugs carrying effect

Active Publication Date: 2022-02-11
厦门宏谱福生物科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when performing this operation, it does not improve the loss of iodized oil that forms milk beads in the blood vessels at the end of the blood vessels.
In addition, due to the mutual adhesion and aggregation of gelatin sponge particles, it is often difficult to reach the peripheral blood supply artery of the tumor to achieve effective embolization, resulting in the formation of tumor collateral vessels; and its re-degradation characteristics lead to incomplete tumor embolization, which is the main reason for tumor recurrence or metastasis.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism
  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism
  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) The medical gelatin sponge particles are mixed with sterile water, then swelled in a water bath at 50° C. to form liquid gelatin, wherein the concentration of gelatin in the sterile water is 20 wt %;

[0035] (2) The liquid gelatin prepared in step (1) and the lipiodol injection containing 48.0% iodine are added to the autoclave at a volume ratio of 0.1:1, pressurized to 20MPa, and the temperature is controlled at 50°C. After the temperature and pressure are stabilized, keep the temperature and pressure and stir for 1 hour;

[0036] (3) After decompression, the prepared injectable gelatin-iodol homogeneous preparation for vascular embolism was collected from the autoclave.

Embodiment 2

[0038] (1) Medical gelatin sponge particles are mixed with DOX-dissolved sterile water, then swollen with a 50°C water bath to form liquid gelatin, wherein the concentration of gelatin in sterile water is 20wt%, and the concentration of DOX in sterile water is 10mg / mL;

[0039] (2) The liquid gelatin prepared in step (1) and the lipiodol injection containing iodine of 48.0% are added to the autoclave at a volume ratio of 0.1:1, pressurized to 20MPa, and the temperature is controlled at 40°C. After the temperature and pressure are stabilized, keep the temperature and pressure and stir for 1 hour;

[0040] (3) After decompression, the prepared hepatic arterial chemoembolization agent was collected from the autoclave.

Embodiment 3

[0042] (1) the medical gelatin sponge particle is mixed with the aseptic water that dissolves water-soluble drug rhodamine, then it is swollen to form liquid gelatin with 50 ℃ of water baths, and wherein the concentration of gelatin in sterile water is 20wt%, rhodamine is in the absence of The concentration in bacterial water is 1mg / mL;

[0043] (2) The liquid gelatin prepared in step (1) and the lipiodol injection containing iodine of 48.0% are added to the autoclave at a volume ratio of 0.1:1, pressurized to 20MPa, and the temperature is controlled at 40°C. After the temperature and pressure are stabilized, keep the temperature and pressure and stir for 1 hour;

[0044] (3) After decompression, collect the prepared hepatic arterial chemoembolization agent from the autoclave;

[0045] (4) Dispersing the fat-soluble drug coumarin-6 in step (3) to prepare a composite embolic agent, wherein the concentration of coumarin-6 in the composite embolic agent is 1 mg / mL.

[0046] Com...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of an injectable gelatin-iodized oil homogeneous preparation for vascular embolism. The method comprises the following steps: (1) mixing gelatin with sterile water, and swelling the mixture in a water bath to form liquid-state gelatin; (2) adding the liquid-state gelatin prepared in the step (1) and an iodized oil injection into a high-pressure kettle, pressurizing to 15-25MPa, controlling the temperature at 30-50 DEG C, and after the temperature and the pressure are stable, keeping the temperature and the pressure and stirring for 0.5-2 hours; and (3) after pressure reduction, collecting the prepared injectable gelatin-iodized oil homogeneous preparation for vascular embolism from the high-pressure kettle. According to the preparation prepared by the invention, in a tumor area in a vascular intervention manner, iodized oil can still gather towards the tumor through a siphonic effect while the effects of embolism enhancement and drug carrying can also be achieved.

Description

technical field [0001] The invention belongs to the technical field of hepatic arterial chemoembolization preparations, in particular to a preparation method and application of an injectable gelatin-iodol homogeneous preparation for vascular embolism. Background technique [0002] Liver cancer is one of the most common malignant tumors in my country. The clinical symptoms are relatively hidden in the early stage of the disease. Most patients with liver cancer are already in the middle and late stages when they see a doctor, resulting in the loss of surgery opportunities. Transarterial chemoembolization (TACE) is the first choice for patients with unresectable advanced liver cancer. However, due to the low viscosity and strong fluidity of the commonly used embolic agent, super liquefied lipiodol, it is easy to be flushed by blood, resulting in easy recanalization of blood vessels, and the dual blood supply and multiple collateral circulation of tumors lead to incomplete tumor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L24/04A61L24/02A61L24/00A61K9/00A61K47/02A61K47/42A61P35/00
CPCA61L24/0068A61L24/0015A61K9/0019A61K47/42A61K47/02A61P35/00A61L2400/06A61L2300/416C08L89/00
Inventor 刘刚陈虎程红伟张洪瑞高兴
Owner 厦门宏谱福生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com