Flexible fiber medicine box capable of intelligently releasing medicines, and preparation and application of flexible fiber medicine box

Abstract

The invention relates to a flexible fiber medicine box capable of intelligently releasing medicines, and preparation and application of the flexible fiber medicine box. The preparation process of the medicine box comprises the steps that firstly, a pore-foaming agent and a high-molecular polymer are sequentially added into an organic solvent, the pore-foaming agent and the high-molecular polymer are evenly mixed to serve as a spinning solution to carry out electrostatic spinning, and a nanofiber membrane is prepared; then, the nanofiber membrane is put into a Tris-hydrochloric acid buffer solution containing dopamine to be subjected to modification treatment, and the nanofiber membrane modified by polydopamine is obtained; then, the nanofiber membrane modified by the polydopamine is put in a mixed solution for grafting reaction to obtain a fiber membrane loaded with a switch; and finally, the fiber membrane loaded with the switch is cleaned and dried to obtain the flexible fiber medicine box. The medicine box comprises porous fibers, and PMAA is chemically grafted at holes on the porous fibers. The prepared medicine box is subjected to medicine carrying treatment, and then a medicine release test is performed: the medicine box does not suddenly release within the first 4-6 hours in an environment with the pH value of 7.0-7.4, and ta medicine release amount is gradually increased along with reduction of the pH value of the medicine release environment.

Description

technical field [0001] The invention belongs to the technical field of dressings, and relates to a flexible fiber medicine box for intelligent drug release and its preparation and application. Background technique [0002] With the development of society and the intensification of population aging, the prevalence of chronic wounds such as pressure sores, ulcers, and diabetic feet is increasing. These wounds have a complex microbial environment, which is prone to bacterial infection and affects wound healing. In order to solve these problems, clinically, systemic administration (intravenous or oral drugs) is usually used to control infection, but this method will not only cause toxicity to the liver and kidneys of the human body, but also reduce the utilization of drugs Rate. The local treatment method of directly using drugs on the wound can effectively improve these shortcomings. However, using drugs directly on the wound will make it difficult to maintain the drug effect...

AI Technical Summary

Problems solved by technology

At present, the existing drug delivery dressings exist in the form of finished products, that is, the drug is loaded in the medium by dipping, mixing and wrapping, and the drug-containing dressing is prepared for subsequent disinfection, packaging, sales and clinical application. The disadvantages are that, firstly, the drug will be released in advance during the subsequent process and transportation, making it difficult to control the final drug loading and release rate, resulting in drug loss; secondly, the various processes of subsequent processing will affect the storage of the drug, and even Cause the physical and chemical effects of the drug to fail; finally, drug-loaded dressings will go through more cumbersome procedures in the approval and registration assurance process, which greatly prolongs the dressing cycle

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