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Production process of microneedle transdermal patch

A production process and technology of transdermal patches, applied in the direction of microneedles, needles, skin diseases, etc., can solve the problems of patients with obvious discomfort and microneedle piercing into the skin, so as to prevent skin allergies, good adhesion, and print pictures image clear effect

Inactive Publication Date: 2021-11-26
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention intends to provide a microneedle transdermal patch production process to solve the problem in the prior art that the microneedle penetrates the skin and the patient feels obvious discomfort

Method used

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  • Production process of microneedle transdermal patch
  • Production process of microneedle transdermal patch
  • Production process of microneedle transdermal patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: 68 cases of rheumatoid arthritis were treated with three types of wind-cold-damp arthralgia, heat-transforming Yin injury, and phlegm and blood stasis. Results: 36 cases were controlled, 16 cases were markedly effective, 11 cases were effective, and 5 cases were ineffective.

Embodiment 2

[0064] Example 2: 42 cases of knee joint swelling, pain, joint pain and discomfort when walking, joint snapping and stiffness. Results: 15 cases were controlled, 21 cases were markedly effective, 3 cases were effective, and 3 cases were ineffective.

Embodiment 3

[0065] Example 3: 40 cases of rheumatoid arthritis of cold-damp blocking collateral type. Results: 11 cases were controlled, 17 cases were markedly effective, 9 cases were effective, and 3 cases were ineffective.

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Abstract

The invention relates to the technical field of medicine patch production, and discloses a production process of a microneedle transdermal patch. The production process comprises the following steps of S1, manufacturing ointment ; S2, manufacturing a medicine carrying layer; and S3, manufacturing the microneedle transdermal patch. According to the production process, the microneedle patch is prepared by using a human body soluble liquid solution, the prepared microneedle is soft, and when the microneedle is punctured into the skin, the needle tip can slowly pierce into the skin, so that the pricking feeling is reduced, and the discomfort of a patient is reduced; and after puncturing, the microneedle can be dissolved by human body fluid, when medicine enters the human body, the microneedle cannot always support the human body, the microneedle hole is in an open state, a patient feels more comfortable, and the problem that in the prior art, the microneedle punctures the skin, and the patient feels uncomfortable obviously is solved.

Description

technical field [0001] The invention relates to the technical field of medicinal plaster production, in particular to a production process of a microneedle transdermal plaster. Background technique [0002] Transdermal drug delivery is through the micro-device for transdermal drug delivery formed by microneedle arrays, that is, the production process of microneedle transdermal patch, which penetrates the main barrier of the stratum corneum of the skin and forms micron-scale "pores" in the epidermis, allowing drug molecules to It flows into the dermis rich in capillaries to effectively deliver drug macromolecules or active ingredients to achieve systemic circulation. It is a minimally invasive transdermal absorption system with low cost, high drug delivery efficiency, and almost negligible side effects. Small, easy to heal, less likely to cause bacterial infection. [0003] At present, the production process of the existing microneedle transdermal patch is generally as follo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K47/32A61K47/34A61K47/26A61K47/18A61K36/486A61P17/02A61P29/00A61P19/02A61M37/00A61K31/7016
CPCA61K9/0021A61K9/7023A61K47/32A61K47/34A61K47/26A61K47/183A61K36/27A61K36/37A61K36/185A61K36/486A61K31/7016A61P17/02A61P29/00A61P19/02A61M37/0015A61K2236/331A61K2236/39A61K2236/51A61M2037/0053A61M2037/0046A61K2300/00
Inventor 严璐杨丽君卯业秦鹏陈义
Owner 贵州中医药大学
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