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Mesoporous silica prodrug nanoparticle for combined photothermal therapy and chemotherapy, and preparation method and application thereof

A technology of mesoporous silica and nanoparticles, which is applied in the field of biomedical nanomaterials, can solve the problems of drug burst release and weak force, and achieve the effect of improving burst release, release acceleration, and good drug loading capacity

Pending Publication Date: 2021-11-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the non-covalent bond between the drug and the material, the force is weak, and the sudden release of the drug is prone to occur.

Method used

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  • Mesoporous silica prodrug nanoparticle for combined photothermal therapy and chemotherapy, and preparation method and application thereof
  • Mesoporous silica prodrug nanoparticle for combined photothermal therapy and chemotherapy, and preparation method and application thereof
  • Mesoporous silica prodrug nanoparticle for combined photothermal therapy and chemotherapy, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] (1) Preparation of mesoporous silica containing surfactant: take 0.2 parts by mass of CTAB, 0.2 parts by mass of FC 2 , 0.018 parts by mass of NaOH and 96 parts by volume of water were mechanically stirred for 0.5 h, then 1.0 parts by volume of ethyl orthosilicate was quickly added, the temperature was raised to 80° C., and the reaction was continued for 2 h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0073] The parts by weight of reactant in the described step (1) are as follows: 0.20 part of CTAB; 0.2 part of FC 2 ; 0.018 parts of sodium hydroxide; 0.96 parts of TEOS; 98.78 parts of water.

[0074] (2) Preparation of surface aminated mesoporous silica: disperse 0.5 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 0.75 parts by volume of sil...

Embodiment 2

[0095] (1) Preparation of mesoporous silica containing surfactant: take 0.15 parts by mass of CTAB, 0.15 parts by mass of FC 2 , 3.75 parts by volume of TEOA solution and 96 parts by volume of water were mechanically stirred for 0.5 h, then 1.0 parts by volume of ethyl orthosilicate was quickly added, the temperature was raised to 80° C., and the reaction was continued for 2 h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0096] The parts by weight of reactant in described step (1) are as follows: 0.15 part of CTAB; 0.15 part of FC 2 ; 0.06 parts TEOA; 0.95 parts TEOS; 98.78 parts water.

[0097] (2) Preparation of surface aminated mesoporous silica: disperse 0.6 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 0.5 parts by volume of silane coupling a...

Embodiment 3

[0109] (1) Preparation of mesoporous silica containing surfactant: take 0.25 parts by mass of CTAB, 0.25 parts by mass of FC 2 , 2.5 parts by volume of ammonia water and 96 parts by volume of water were mechanically stirred for 0.5 h, then 1.0 parts by volume of ethyl orthosilicate was quickly added, the temperature was raised to 80° C., and the reaction was continued for 2 h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0110] The parts by weight of reactant in described step (1) are as follows: 0.25 part of CTAB; 0.25 part of FC 2 ; 0.10 parts of ammonia; 0.95 parts of TEOS; 98.78 parts of water.

[0111](2) Preparation of surface aminated mesoporous silica: disperse 0.5 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 1.0 volume parts of silane cou...

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Abstract

The invention belongs to the technical field of biomedical nanomaterials, and discloses a mesoporous silica prodrug nanoparticle with pH responsiveness and combined effects of near-infrared dye molecule photothermal therapy and adriamycin chemotherapy as well as a preparation method and application of the mesoporous silica prodrug nanoparticle. The nanoparticle is composed of a mesoporous silica nanoparticle, a drug bonded on the surface of the mesoporous silica nanoparticle, a polymer modified on the surface of the mesoporous silica nanoparticle, and an organic photo-thermal small molecule loaded in the pore channel of the mesoporous silica nanoparticle. According to the mesoporous silica prodrug nanoparticle disclosed by the invention, controllable release of the drug is realized by utilizing an acid-sensitive cis-aconitic anhydride bond, namely the drug is almost not released around normal cells and is quickly released in a subacid environment of tumor cells, so targeted therapy of tumors is realized. Near-infrared radiation not only causes the increase of local temperature, but also accelerates the release of the drug, is helpful for the drug to quickly reach a desired blood concentration, and realizes the synergistic effect of photo-thermal / chemical therapy.

Description

technical field [0001] The invention belongs to the technical field of biomedical nanomaterials, and in particular relates to a mesoporous silica prodrug nanoparticle used for photothermal therapy combined with chemotherapy and its preparation method and application. The mesoporous silica prodrug nanoparticle has pH-responsive, can be combined with near-infrared dye molecules to achieve photothermal therapy and doxorubicin chemotherapy. Background technique [0002] Among the various cancer treatment methods currently available, the traditional chemotherapy is to kill cancer cells through oral or intravenous injection of anticancer drugs through the blood circulation system to the tumor site. Although chemotherapy is not the best treatment option, it is still the most common option for most patients. However, pure chemotherapy has certain limitations in clinical application. For example, anticancer drugs often have strong cytotoxicity and lack the ability to specifically re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/60A61K47/54A61K47/69A61K9/52A61K47/04A61K41/00A61K31/704A61P35/00B82Y5/00B82Y40/00
CPCA61K47/60A61K47/545A61K47/543A61K47/6923A61K9/5115A61K41/0052A61K31/704A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 章莉娟彭诗元张富盛
Owner SOUTH CHINA UNIV OF TECH
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