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Preparation method of rice-grain-shaped hydroxyl alumina nano adjuvant with good suspension stability

A technology of aluminum oxyhydroxide and suspension stability, which is applied in the field of preparation of aluminum oxyhydroxide adjuvant materials, can solve the problems of insufficient vaccine administration and reduced vaccine effect, and achieve excellent suspension stability, good homogeneity and immunogenicity permanent, easy-to-disperse effect

Pending Publication Date: 2021-11-16
DALIAN UNIV OF TECH
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  • Claims
  • Application Information

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Problems solved by technology

Based on the need to solve the problem of redispersion of the final product of the aluminum adjuvanted vaccine formulation after storage, the vaccine with poor homogeneity during the administration process will lead to reduced vaccine efficacy or insufficient vaccine administration, so the study of synthetic dispersibility, Good suspension stability, easy to resuspend aluminum oxyhydroxide adjuvant is of great significance

Method used

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  • Preparation method of rice-grain-shaped hydroxyl alumina nano adjuvant with good suspension stability
  • Preparation method of rice-grain-shaped hydroxyl alumina nano adjuvant with good suspension stability
  • Preparation method of rice-grain-shaped hydroxyl alumina nano adjuvant with good suspension stability

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Embodiment 1

[0028] Accurately weigh 0.9375g of aluminum nitrate nonahydrate with 0.3g (the molar ratio of aluminum salt to basic solid is 1:2), 0.6g (the molar ratio of aluminum salt to basic solid is 1:4), 0.9g (aluminum salt The molar ratio of the basic solid to the basic solid is 1:6), 1.95g of urea (the molar ratio of the aluminum salt to the basic solid is 1:13) is dissolved in 50mL of deionized water at room temperature, and the stirring rate of the solution is controlled at 500rpm until Dissolves completely in deionized water to form a transparent and clear solution. The clear and transparent solution was transferred to a 50ml autoclave, and the hydrothermal conditions were controlled at a hydrothermal temperature of 165°C and a hydrothermal time of 70min. After the reaction was completed, it was left to cool to room temperature, and then the product began to be collected. After naturally cooling to room temperature, wash with ethanol and then deionized water two to three times to...

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Abstract

The invention discloses a preparation method of a rice-grain-shaped hydroxyl alumina nano-material with good suspension stability, the method uses a mixed solution of inorganic aluminum salt and urea as a reactant, a nano-sized hydroxyl alumina adjuvant is prepared through a hydrothermal method, and the prepared hydroxyl alumina adjuvant nano-material has the advantages of uniform morphology, uniform dispersion, and good homogeneity and immunogenicity. Compared with the existing commercial hydroxyl aluminum oxide adjuvant, the rice-grain-shaped hydroxyl aluminum oxide adjuvant has outstanding and excellent suspension stability, and has a good prospect in vaccine preparation, production and application.

Description

technical field [0001] The invention relates to a preparation method of an aluminum oxyhydroxide adjuvant material with good suspension stability and good immunogenicity, in particular to a preparation method of a nanometer aluminum oxyhydroxide adjuvant and characterization of related properties. Background technique [0002] The discovery of vaccines can be described as a milestone event in the history of human development. The most important means of controlling infectious diseases is prevention, and vaccination is considered the most effective measure. As an important part of vaccines, adjuvants play an extremely important role in directing and enhancing the immune response to antigens. Adjuvants can induce the human body to produce a long-term and highly efficient specific immune response, thereby improving the human body's protective ability. Common aluminum adjuvants in preventive vaccines include aluminum oxyhydroxide and aluminum phosphate, and aluminum oxyhydroxid...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61P37/04B82Y5/00B82Y40/00C01F7/34
CPCA61K39/39A61P37/04B82Y5/00B82Y40/00C01F7/34A61K2039/55505C01P2006/22
Inventor 孙冰冰毕世升薛长颖梁智慧李敏
Owner DALIAN UNIV OF TECH
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