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Modified polylactic acid material as well as preparation method and application thereof

A polylactic acid material, polylactic acid technology, applied in medical science, surgery, etc., can solve the problems of compatibility, degradation and poor mechanical properties, and achieve the effect of retaining modulus and enhancing compatibility

Inactive Publication Date: 2021-11-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a blended modified polylactic acid material for a fully degradable vascular stent and a preparation method thereof. The modified polylactic acid material can effectively solve the problems existing in existing materials. Problems of compatibility, degradability and poor mechanical properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A modified polylactic acid material, the preparation method of which is as follows:

[0021] (1) Preparation of block polymer: Add double-terminal hydroxyl polycaprolactone (PCL), lactide and stannous octoate with a molecular weight of 2000 into the reaction flask, double-terminal hydroxyl polycaprolactone (PCL), lactide The mass ratio of ester to stannous octoate is 2:2:0.04; vacuum removes oxygen, protects with nitrogen, repeats three times; then puts the reaction bottle in an oil bath, heats up to 130°C, reacts for 48 hours, and the viscosity of the system increases significantly It shows that the ring-opening is successful. After cooling to room temperature, the system solidifies into a solid, which again shows that the ring-opening is successful; then add chloroform to the solid to dissolve it, and then add a large amount of ethanol to precipitate the product, repeat three times, collect the precipitate, and then store it under vacuum at 60°C drying at lower temper...

Embodiment 2

[0024] A modified polylactic acid material, the preparation method of which is as follows:

[0025] (1) Preparation of block polymer: polylactic acid-glycolic acid copolymer (PLGA), lactide and stannous octoate with a molecular weight of 4000 are added to the reaction flask, polylactic acid-glycolic acid copolymer (PLGA), lactide The mass ratio of ester to stannous octoate is 2:1.5:0.04; vacuum removes oxygen, protects with nitrogen, repeats three times; then puts the reaction bottle in an oil bath, heats up to 150°C, reacts for 48 hours, the viscosity of the system increases significantly It shows that the ring opening is successful. After cooling to room temperature, the system solidifies into a solid, which again shows that the ring opening is successful. Then add chloroform to the solid to dissolve it, and then add a large amount of methanol to it to precipitate the product. Repeat three times, collect the precipitate, and then store it under vacuum at 60°C. drying at lowe...

Embodiment 3

[0028] A modified polylactic acid material, the preparation method of which is as follows:

[0029] (1) Preparation of block polymer: polydioxanone (PDO), lactide and dibutyltin dilaurate with molecular weight 2000 are added in the reaction flask, polydioxanone (PDO) , lactide and dibutyltin dilaurate in a mass ratio of 1:2:0.05, vacuum removed oxygen, nitrogen protection, repeated three times; then the reaction bottle was placed in an oil bath, heated to 120 ° C, reacted Hours, the viscosity of the system increased significantly, indicating that the ring-opening was successful. After cooling to room temperature, the system solidified into a solid, indicating that the ring-opening was successful again; Three times, and finally dried under vacuum at 60°C to obtain a block polymer;

[0030] (2) Polylactic acid, polydioxanone (PDO) and block polymer in step (1) are dissolved in hexafluoroisopropanol, polylactic acid, polydioxanone (PDO) and The mass ratio of the block polymer i...

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PUM

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Abstract

The invention discloses a modified polylactic acid material as well as a preparation method and application thereof. The modified polylactic acid material comprises polylactic acid, a polymer and a block polymer, wherein the mass ratio of the polylactic acid to the full-degradable polymer to the block polymer is (0.3-0.7): (0.2-0.5): (0.03-0.1). The modified polylactic acid material can effectively solve the problem that an existing polylactic acid material is poor in compatibility, degradability and mechanical property.

Description

technical field [0001] The invention relates to the technical field of polylactic acid materials, in particular to a modified polylactic acid material and its preparation method and application. Background technique [0002] At present, minimally invasive interventional vascular stent is one of the most commonly used methods for the treatment of coronary heart disease. Traditional stents are metal-based drug-coated stents, which are non-degradable, and their physical structure and mechanical properties are poorly matched with vascular tissue, which can easily lead to late vascular restenosis and various complications. Fully degradable absorbable polymer stents can be gradually degraded to complete absorption, matching the tissue repair of blood vessels, and can avoid the adverse effects of non-degradable metal stents. [0003] At present, most of the absorbable polymer scaffolds used in clinical practice are made of polylactic acid materials. Polylactic acid materials have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08G63/08A61L31/04A61L31/14
Inventor 王云兵魏媛张凡军罗日方李高参杨立
Owner SICHUAN UNIV
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