Active polypeptide-PDRN composition and application thereof in preparation of nursing products

A-PDRN, active polypeptide technology, applied in the field of oral care products, can solve the problems of cumbersome extraction of active ingredients, difficult animal cell culture, unclear structure of active ingredients, etc., to enhance cell penetration and prevent recurrent oral cavity Ulcer, the effect of regulating cellular immunity

Active Publication Date: 2021-11-02
润辉生物技术(威海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, long-term use of antibiotic ingredients can easily lead to drug resistance of bacteria, reduce the curative effect, and fail to achieve the therapeutic effect; animal cells have the defects of difficult cultivation and high production costs; the active ingredients of traditional Chinese medicine have unclear structures, complex chemical ingredients, and The content is low, the mechanism of action is not clear, and the steps of extracting active ingredients from plants are relatively cumbersome, and the content and effect of active ingredients in traditional Chinese medicine are easily affected by different origins and sources of different years; long-term use of antibiotics can easily lead to drug resistance, reducing Curative effect, not reaching therapeutic effect

Method used

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  • Active polypeptide-PDRN composition and application thereof in preparation of nursing products
  • Active polypeptide-PDRN composition and application thereof in preparation of nursing products
  • Active polypeptide-PDRN composition and application thereof in preparation of nursing products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The construction of embodiment 1 protamine-PDRN complex

[0064] First, 30 mg / L protamine solution and 30 mg / L PDRN solution were mixed, and stirred at room temperature for 1 h; then the mixture was allowed to stand at room temperature for 1 h; finally, the mixture was freeze-dried to obtain a protamine-PDRN complex.

Embodiment 2

[0065] Example 2 Construction of Percyganan-antimicrobial peptide LL37-protamine-PDRN complex

[0066] First, mix the solution containing 5mg / L Percyganan, 10mg / L antibacterial peptide LL37 and 10mg / L protamine with the 30mg / LPDRN solution, and stir at room temperature for 1h; then let the mixture stand at room temperature for 1h; finally mix the The solution was freeze-dried to obtain the Percyganan-antimicrobial peptide LL37-protamine-PDRN complex.

Embodiment 3

[0067] Example 3 Construction of Percyganan-antimicrobial peptide LL37-defensin HNP1-protamine-PDRN complex

[0068] First, mix the solution containing 5mg / L Percyganan, 5mg / L antimicrobial peptide LL37, 5mg / L defensin HNP1 and 15mg / L protamine with 40mg / L PDRN solution, and stir at room temperature for 1h; Stand at room temperature for 1 hour; finally, freeze-dry the mixture to obtain the Percyganan-antimicrobial peptide LL37-defensin HNP1-protamine-PDRN complex.

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Abstract

The invention relates to an active polypeptide-PDRN composition and application thereof in preparation of nursing products, and provides the active polypeptide-PDRN composition which can play a role in inhibiting oral ulcer and gastric ulcer caused by helicobacter pylori by matching with matrix substances. The traditional Chinese medicine composition solves the problems that oral ulcer is easy to relapse and difficult to cure in the prior art, can promote healing of formed oral ulcer, can effectively prevent relapse of bacterial gastric ulcer, can fundamentally remove helicobacter pylori in the oral cavity, and effectively reduces relapse of bacterial gastric ulcer. The product provided by the invention takes the cationic antibacterial peptide, the PDRN and the anti-inflammatory repair peptide as main functional components, has good biocompatibility, is safe and non-toxic to a human body, and also provides a preparation method and an application method of the product. The invention is widely applied to the technical field of medicines for preventing and treating ulcers.

Description

technical field [0001] The invention belongs to the technical field of oral care products, and in particular relates to the application of an active polypeptide-PDRN composition in oral care products and antibacterial products. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Oral ulcer is a common ulcerative injury that occurs on the mucous membranes of the lips, cheeks, soft palate or gums, and usually heals in about a week. Recurrent oral ulceration (RAU) has the characteristics of periodicity, recurrence and self-limitation, and the course of the disease is generally one to two weeks. The pain that can be produced during the onset of oral ulcers will have a great impa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K47/64A61K47/55A61K8/64A61K8/60A61P1/02A61P1/04A61P31/04A61Q11/00A61K38/07A61K38/06A61K31/7088
CPCA61K38/1729A61K38/1706A61K38/07A61K38/06A61K31/7088A61K47/64A61K47/55A61K8/64A61K8/606A61Q11/00A61P1/02A61P31/04A61P1/04A61K2800/5922A61K2300/00Y02A50/30
Inventor 姬胜利王盈盈殷金岗
Owner 润辉生物技术(威海)有限公司
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