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Application of teduglutide in preparation of medicine for treating myocardial ischemia reperfusion injury

A technology for reperfusion injury and myocardial ischemia, applied in the field of medicine, can solve the problem that the specific mechanism needs to be further studied, and achieve the effect of reducing myocardial ischemia-reperfusion injury, protecting cardiac function and protecting integrity.

Pending Publication Date: 2021-10-29
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Breakthrough studies in recent years have found that the role of GLP-2 is not limited to the intestinal tract, but has been proven to reduce inflammatory damage in the liver and nervous system, and its specific mechanism needs to be further studied

Method used

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  • Application of teduglutide in preparation of medicine for treating myocardial ischemia reperfusion injury
  • Application of teduglutide in preparation of medicine for treating myocardial ischemia reperfusion injury
  • Application of teduglutide in preparation of medicine for treating myocardial ischemia reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Effect of Different Doses of Teduglutide on Myocardial Ischemia-Reperfusion Injury

[0038] Materials: small animal ventilator, animal surgical lighting, and gas anesthesia system were purchased from Shanghai Yuyan Scientific Instrument Co., Ltd.; surgical microscopic instruments were purchased from Zhenmei Medical Instrument Co., Ltd.; 4-0 / 7-0 sutures were purchased from Ningbo Medical Suture Needle Co., Ltd.; 2,3,5-triphenyltetrazolium chloride (TTC) and Evan&Blue were purchased from Sigma, USA.

[0039] To establish a mouse myocardial ischemia-reperfusion model: 8-week-old male C57BL / 6 mice were randomly divided into a sham operation group (sham group), a normal saline group (Saline group), a teduglutide 300 μg / kg group (300 μg / kg kg GLP-2 group), teduglutide 600 μg / kg group (600 μg / kg GLP-2 group) and teduglutide 1200 μg / kg group (1200 μg / kg GLP-2 group), 5 rats in each group. Modeling method: mice were anesthetized with isoflurane, tracheal intubation wa...

Embodiment 2

[0042] Example 2 Teduglutide treatment significantly improved cardiac function after myocardial ischemia-reperfusion and increased survival rate.

[0043] Materials: small animal ventilator, animal surgical lights, and gas anesthesia system were purchased from Shanghai Yuyan Scientific Instrument Co., Ltd., surgical microscopic instruments were purchased from Zhenmei Medical Instrument Co., Ltd., and 4-0 / 7-0 sutures were purchased from Ningbo Medical Suture Needle Co., Ltd., and small animal cardiac ultrasound equipment were purchased from VisualSonics, Canada.

[0044] Measurement of cardiac function by echocardiography: 8-week-old male C57BL / 6 mice were randomly divided into sham operation group (sham group), normal saline group (Saline group), teduglutide group (600μg / kg GLP-2 group) , 9 mice in each group, the mouse myocardial ischemia-reperfusion model was constructed as described above, the sham operation group was only threaded through without ligation, and the teduglut...

Embodiment 3

[0047] Example 3 Teduglutide treatment significantly reduces the formation of microcirculation disorder (Microvascular obstruction, MVO) after myocardial ischemia-reperfusion

[0048] Materials: The small animal ventilator, animal surgical lighting, and gas anesthesia system were purchased from Shanghai Yuyan Scientific Instrument Co., Ltd. Surgical microinstruments were purchased from Zhenmei Medical Instrument Co., Ltd. 4-0 / 7-0 sutures were purchased from Ningbo Medical Suture Needle Co., Ltd. Thioflavin S dye was purchased from Biosharp.

[0049]Calculation of MVO area by thioflavin S staining: 8-week-old male C57BL / 6 mice were randomly divided into sham operation group (sham group), normal saline group (Saline group), teduglutide group (600 μg / kg GLP-2 group), 5 in each group. The mouse myocardial ischemia-reperfusion model was constructed as described above, and the sham operation group was only threaded through without ligation. The teduglutide group was subcutaneous...

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Abstract

The invention discloses application of teduglutide in preparation of a medicine for treating myocardial ischemia reperfusion injury. The teduglutide can protect the integrity of an intestinal barrier after myocardial ischemia, prevent intestinal flora displacement and intestinal flora imbalance, and relieve myocarditis reaction after myocardial ischemia reperfusion so as to treat the myocardial ischemia reperfusion injury. Compared with antibiotic therapy, probiotic intervention, coprophilous fungus transplantation and the like, the invention has a higher clinical transformation value and clinical application realizability. The invention discovers that the teduglutide has the effect of treating the myocardial ischemia reperfusion injury after myocardial infarction and can be used for preparing the medicine for treating acute myocardial infarction, and a new treatment scheme is provided for clinical treatment of the myocardial ischemia reperfusion injury.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of teduglutide in the preparation of medicines for treating myocardial ischemia-reperfusion injury. Background technique [0002] With the development of the economy and the improvement of people's living standards, the number of patients with acute myocardial infarction (AMI) has increased year by year, and it has become the leading cause of death and disability in my country. Acute myocardial infarction is a myocardial necrotic disease caused by acute coronary artery occlusion, and rapid and complete opening of the occluded vessel is the main treatment. Since the beginning of the 21st century, with the popularity of emergency coronary intervention, more and more AMI patients have received timely revascularization treatment, and the mortality rate of AMI has decreased significantly. However, reperfusion injury leads to further death of a large number of cardi...

Claims

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Application Information

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IPC IPC(8): A61K38/26A61P9/10A61P29/00
CPCA61K38/26A61P9/10A61P29/00
Inventor 谢峻赵金璇程伟
Owner NANJING DRUM TOWER HOSPITAL
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