Application of CX-5461 in treatment of renal transplantation immunological rejection

A technology of immune rejection and kidney transplantation, applied in the field of biomedicine to achieve the effects of prolonging survival, inhibiting acute rejection, and improving the level of

Active Publication Date: 2022-06-24
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the effect of CX-5461 on immune rejection of renal transplantation, especially on acute rejection after renal transplantation and renal ischemia-reperfusion injury after renal transplantation

Method used

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  • Application of CX-5461 in treatment of renal transplantation immunological rejection
  • Application of CX-5461 in treatment of renal transplantation immunological rejection
  • Application of CX-5461 in treatment of renal transplantation immunological rejection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1CX-5461

[0036] Example 1The effect of CX-5461 on immune rejection after renal transplantation in rats

[0037] 1. Experimental method

[0038] (1) Lewis male rats and Brown Norway male rats were purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. Body weight is about 200g, 6-8 weeks old, and the rearing environment is carried out according to SPF level.

[0039](2) Establishment of acute rejection model after kidney transplantation in rats: The donor kidneys from Brown Norway male rats aged 6-8 weeks and about 200 g were transplanted into Lewis male rats. Vein end-to-end anastomosis. The experimental group was divided into the normal group (Control) as the donor rats, the acute rejection group (AR) and the drug group (CX54612mg / kg) with 5 rats each. After successful renal transplantation in rats, the rats were sacrificed 3 days, 5 days, and 7 days after the operation, and blood was collected in the infrarenal abdominal aorta by using a 5 mL sterile syringe. ...

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Abstract

The invention discloses a novel application of CX-5461 in preparation of a medicine for treating renal transplantation immunological rejection. The research shows that CX-5461 can obviously reduce the occurrence of renal transplantation immunological rejection, specifically, the fibrosis degree and immune infiltration degree of a renal graft are reduced, the creatinine and urea nitrogen levels in blood after a rat renal transplantation operation are reduced, the IL-17A cell factor level of the rat renal graft and the in-vivo proinflammatory IL-6 cell factor level are reduced, and the like. Compared with the prior art, the CX-5461 has the advantages that the CX-5461 can be used as a novel immunosuppressive agent for treating renal transplantation immunological rejection, especially acute rejection after renal transplantation, and can be used for preventing and treating renal transplantation immunological rejection, and the survival time of rats can be prolonged, and the long-term survival rate of rats after renal transplantation can be obviously prolonged. The CX-5461 can be used as a novel immunosuppressive agent for treating renal transplantation immunological rejection, especially acute rejection after renal transplantation.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, more particularly, to the application of CX-5461 in the treatment of immune rejection of kidney transplantation. Background technique [0002] Kidney transplantation has become one of the main treatments for patients with end-stage renal disease, but immune rejection caused by allogeneic organs seriously affects the lifespan of the transplanted organ. There are many factors affecting the survival of transplanted kidney, which are mainly divided into two aspects: pre-transplantation and post-transplantation. The factors before transplantation mainly include brain death and organ ischemia time; the factors after transplantation mainly include reperfusion injury, infection, rejection, nephrotoxicity and so on. Among them, acute rejection is the most common complication after kidney transplantation. [0003] Acute rejection is the most common rejection after kidney transplantation, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/551A61P37/06A61P13/12
CPCA61K31/551A61P37/06A61P13/12
Inventor 陈红波石培霖程芳刘龙山王长希毕梓荣
Owner SUN YAT SEN UNIV
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