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Injectable rhBMP-2-containing bone repair hydrogel and preparation method thereof

A technology of composite hydrogel and rhbmp-2, applied in the field of biomedical materials, can solve the problems of short half-life of rhBMP-2, difficult to maintain effective drug concentration, etc., and achieve the effect of good sustained-release function and high-efficiency treatment method

Pending Publication Date: 2021-10-22
南京宁宇医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bone repair is a long-term process. Due to the short half-life of rhBMP-2, it will be metabolized and absorbed quickly when it is applied locally, and it is difficult to maintain an effective drug concentration.

Method used

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  • Injectable rhBMP-2-containing bone repair hydrogel and preparation method thereof
  • Injectable rhBMP-2-containing bone repair hydrogel and preparation method thereof
  • Injectable rhBMP-2-containing bone repair hydrogel and preparation method thereof

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Embodiment 1

[0030] The preparation method of embodiment 1 hydrogel

[0031] (1) Preparation of nano-hydroxyapatite

[0032] Dissolve 5g of calcium nitrate in 100ml of deionized water, add 0.4g of sodium citrate, stir until completely dissolved, adjust the pH of the solution to 11 with 5mol / L ammonia water, and obtain solution A; dissolve 1.675g of diammonium hydrogen phosphate in 60ml of deionized water Obtain solution B in ionized water; then start the high-gravity rotating packed bed (RPB), adjust the rotation speed to 2500rpm, and transport the two solutions of A and B to the RPB respectively. 10min, the resulting nano-HAP dispersion. Vacuum drying to obtain nHAP powder.

[0033] (2) Preparation of hyaluronic acid derivatives

[0034] Dissolve 1g of hyaluronic acid in 200ml of deionized water, add 12.5g of adipic acid dihydrazide (ADH) after dissolving and stir evenly, then add 2g of 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide hydrochloride (EDC) catalyzed the reaction, then adj...

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Abstract

The invention relates to injectable rhBMP-2-containing bone repair hydrogel and a preparation method thereof, and belongs to the technical field of biomedical engineering. The hydrogel material contains recombinant human bone morphogenetic protein-2 (rhBMP-2), nano-hydroxyapatite, a hyaluronic acid-adipic acid dihydrazide derivative and an alginic acid derivative with an aldehyde group on a main chain. The preparation method comprises the following steps: preparing the nano-hydroxyapatite, preparing the sodium alginate hyaluronic acid derivative, preparing the composite hydrogel and the like. A novel repairing method is provided for bone defect treatment, and has wide application prospect and ideal repairing effect.

Description

technical field [0001] The invention relates to the field of biomedical materials containing active protein and the technical field of biomedical engineering, in particular to an injectable rhBMP-2-containing bone repair hydrogel and a preparation method thereof. Background technique [0002] With the intensification of the aging society, the incidence of bone diseases such as fractures, bone tumors, and osteoporosis has increased rapidly. The resulting bone defects not only seriously threaten the physical and mental health of patients, but also bring huge economic burdens to society. Autologous bone grafting has always been considered the "gold standard" for the treatment of bone defects, but its application has the disadvantages of limited source of autologous bone and additional damage to the donor site. Allogeneic bone grafts have also been used clinically, but problems such as high failure rate and immune rejection also limit their application. In recent years, biomate...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/20A61L27/50A61L27/52A61L27/54
CPCA61L27/20A61L27/12A61L27/54A61L27/52A61L27/50A61L2400/06A61L2430/02A61L2300/414A61L2300/604C08L5/08C08L5/04
Inventor 孙亚党瑞杰朱彪
Owner 南京宁宇医疗器材有限公司
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