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Baicalin hydrogel and preparation method thereof

A technology of baicalin and hydrogel, which is applied in the direction of pharmaceutical formulations, medical preparations containing non-active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of excessive use of dosage form excipients, low tissue retention, and poor solubility of baicalin and other problems, to achieve the effect of improving mechanical strength, high biocompatibility, and good antibacterial ability

Pending Publication Date: 2021-10-22
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to overcome the deficiencies of the prior art, provide a baicalin hydrogel and its preparation method and application, solve the problems of poor solubility of baicalin, low tissue retention, and the use of more dosage form auxiliary materials, and Retains various biological activities of baicalin

Method used

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  • Baicalin hydrogel and preparation method thereof
  • Baicalin hydrogel and preparation method thereof
  • Baicalin hydrogel and preparation method thereof

Examples

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Embodiment 1

[0029] Embodiment 1. Carry out comparison around the former protection scope

[0030] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0031] All materials and instruments used in the following examples are commercially available.

[0032] Embodiment 1, the preparation of baicalin hydrogel

[0033] A baicalin hydrogel, including baicalin and boron source, was prepared by the following method: weigh baicalin (44 mg) and sodium tetraborate (10 mg) and dissolve them in deionized water (1 mL), add sodium hydroxide The solution (5 M) was adjusted to pH 8....

Embodiment 2

[0034] Embodiment 2, the preparation of baicalin hydrogel

[0035] A baicalin hydrogel, including baicalin and boron source, was prepared by the following method: weigh baicalin (44 mg) and sodium tetraborate (10 mg) and dissolve them in deionized water (1 mL), add sodium hydroxide The pH of the solution (5 M) was adjusted to 9.0, stirred in a water bath at 60 °C until completely dissolved, and then allowed to stand at room temperature for 30 min to obtain a uniform and stable yellow jelly-like gel.

Embodiment 3

[0036] Embodiment 3, the preparation of baicalin hydrogel

[0037] A baicalin hydrogel, including baicalin and boron source, was prepared by the following method: weigh baicalin (22 mg) and sodium tetraborate (20 mg) and dissolve them in deionized water (1 mL), add sodium hydroxide The pH of the solution (5 M) was adjusted to 8.6, stirred in a water bath at 60°C until completely dissolved, and then allowed to stand at room temperature for 30 min to obtain a uniform and stable yellow jelly-like gel.

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to baicalin hydrogel and a preparation method thereof; the hydrogel is prepared from baicalin and a boron source in an aqueous solution. Based on the wide pharmacological activity of the baicalin, the baicalin hydrogel is developed and prepared by utilizing the dynamic covalent binding effect of the baicalin and boron and the non-covalent bond effect between baicalin molecular parent nucleuses. The hydrogel is easy to prepare, high in stability, high in drug content and long in local residence time, has excellent formability, thixotropy, self-healing property, pH sensitivity and slow release property, and can significantly inhibit the growth of staphylococcus aureus. The baicalin hydrogel is high in biocompatibility, has various pharmacological activities such as antibacterial activity, anti-inflammatory activity and anti-tumor activity, can be used as a drug carrier for external administration and local injection administration, and has huge clinical application potential.

Description

technical field [0001] The invention relates to the field of medicament preparation, in particular to a baicalin hydrogel and a preparation method thereof. Background technique [0002] The active small molecule hydrogel formed by the direct polymerization or self-assembly of active small molecules is a new type of smart material, which has many advantages such as high biocompatibility, easy degradation and absorption, and wide range of pharmacological activities. It is used in cell culture, tissue engineering, It has great application potential in medical materials, drug delivery and other fields. This type of hydrogel has high requirements on the structure of small molecular compounds, and there are few related reports so far. [0003] Baicalin, the main component of traditional Chinese medicine Scutellaria baicalensis, has multiple targets. It can affect the expression of IL-1B, IL-6, TNF, NOS2, NFKBIA and other target genes in vivo, and regulate NLRP3 / caspase-1, TLR4 / NF...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/06A61K47/52A61P17/18A61P17/00A61P17/04A61P29/00A61P17/02
CPCA61K31/7048A61K9/06A61K9/0014A61K9/0019A61K47/52A61P17/18A61P17/00A61P17/04A61P29/00A61P17/02
Inventor 王真真贾媛曹利华贺红娟苗明三李秀敏
Owner HENAN UNIV OF CHINESE MEDICINE
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