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Novel litholytic agent

A stone-dissolving agent and stone-dissolving technology, which is applied in the direction of active ingredients of artificially synthesized polymer materials, digestive system, ether/acetal active ingredients, etc., can solve the stone-dissolving effects of pigment-type gallstones and mixed gallstones Unsatisfactory, large human side effects and other problems, to achieve the effect of shortening the time of stone dissolution, less residue, and low toxicity

Pending Publication Date: 2021-10-22
宁海德宝立新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason people carry out exploration and research to multiple stone-dissolving agents, but current stone-dissolving agents have relatively large side effects on the human body, and are unsatisfactory to pigment type gallstones and mixed type gallstones. Further research to be able to perform lytic therapy for intrahepatic bile duct stones, gallbladder stones and choledocholithiasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Mix polyethylene glycol butyl ether and water according to the volume ratio of 10mL:1mL, 8mL:4mL, and 5mL:5mL, and stir magnetically for 2 minutes to obtain uniform and stable stone-dissolving agent 1-1, stone-dissolving agent 1-2, and dissolving agent 1-2. Lithium 1-3.

[0062] Weigh three complete cholesterol-type gallstones of about 0.12g (the gallstones come from a patient, female, 44 years old) and put them into the above-mentioned stone-dissolving agent respectively, and use an ultrasonic cleaning machine (ultrasonic power 240W) to break and dissolve the gallstones, every 10min Record an experiment. At 10 minutes, the gallstones in the stone-dissolving agent 1-1 were completely dissolved, and after the cholesterol-type gallstones were completely dissolved, the color of the stone-dissolving agent changed from colorless and transparent to dark yellow and transparent; at 30 minutes, the gallstones in the stone-dissolving agent 1-2 were completely dissolved. Dissolve...

Embodiment 2

[0067] Swelling of latex tubes used in gallstone-dissolving surgery by litholytic agents. Different solvents lead to different swelling degrees of latex tubes, and severe swelling will have a great negative impact on gallstone dissolving surgery.

[0068] Investigate the effect of the following stone-dissolving agents on the swelling degree of latex tubing:

[0069] Stone dissolving agent 1-1: polyethylene glycol butyl ether: water = 10mL: 1mL.

[0070] Take the latex tube and completely soak it in the above-mentioned stone-dissolving agent for 24 hours, then compare the changes in mass, volume and length of the latex tube before and after soaking. Deionized water was used as the negative control group, and traditional stone-dissolving agents such as isoamyl acetate and methyl tert-butyl ether were used as the positive control group.

[0071] Before soaking, weigh the quality of the latex tube, and measure the length of the latex tube with a steel ruler. Add quantitative de...

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Abstract

The invention provides a polyethylene glycol butyl ether litholytic agent which is low in toxicity and small in side effect, and can be used for treating intrahepatic calculus of bile duct. The litholytic agent is a water-soluble litholytic agent, the concentration of the polyethylene glycol monobutyl ether is conveniently reduced, litholytic course can be carried out under the condition of bile residues, cleaning is convenient after the litholytic course, and residues are reduced. The litholytic agent provided by the invention can be used for dissolving gallstone, extrahepatic bile duct calculus and intrahepatic bile duct calculus, and is small in side effect, so that the litholytic agent is expected to be used for non-surgical treatment of clinical gall-stone patients.

Description

technical field [0001] The invention relates to a novel stone-dissolving agent for dissolving gallstones, in particular to a polymer stone-dissolving agent. Background technique [0002] Bile is the secretion of liver cells, 97% of which is water, containing bile acids, bile salts, cholesterol, bile pigments, fatty acids, lecithin and inorganic salts, etc. The daily bile secretion of adults is about 800-1000ml. After bile is secreted by the liver cells, it flows into the duodenum through the hepatic duct and the common bile duct, or flows into the gallbladder from the hepatic duct and the cystic duct for storage, and then is discharged from the gallbladder into the duodenum when needed for digestion. When the concentration of cholesterol in the bile is too high, it will be precipitated and form gallstones. Therefore, gallstones can be divided into intrahepatic bile duct stones, gallbladder stones and common bile duct stones according to the location of the disease. Accordi...

Claims

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Application Information

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IPC IPC(8): A61K31/08A61K31/77A61P1/16
CPCA61K31/08A61K31/77A61P1/16
Inventor 宋红红陈梓衡张杰倪磊凌晓峰徐怡庄冯娟
Owner 宁海德宝立新材料有限公司
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