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Application of ferula asafoetida sesquiterpene lactone in preparation of anti-schistosomiasis drug

A technology of sesquiterpene lactone and schistosomiasis, applied in the field of medicine, can solve the problems of early embryo toxicity, troublesome treatment of malaria, etc., and achieve the effect of obvious estrogen reduction effect, obvious killing effect, broad market application prospect and application value.

Inactive Publication Date: 2021-09-28
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the early 1980s, some researchers discovered that artemisinin has the activity of killing schistosomiasis, and then found that various derivatives of artemisinin such as artemether, artether, artesinate, artesunate, dihydroartemisinin Both methyl ether and reduced artemisinin have a certain inhibitory effect on schistosomes, but artemisinin and its derivatives have certain toxicity to early embryos
At the same time, the treatment of schistosomiasis with artemisinin and its derivatives will bring trouble to the treatment of malaria

Method used

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  • Application of ferula asafoetida sesquiterpene lactone in preparation of anti-schistosomiasis drug
  • Application of ferula asafoetida sesquiterpene lactone in preparation of anti-schistosomiasis drug
  • Application of ferula asafoetida sesquiterpene lactone in preparation of anti-schistosomiasis drug

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Experimental program
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Effect test

Embodiment 1

[0020] 1. Extraction of Ferulic Sesquiterpene Lactone

[0021] Take Xinjiang ferulicum, extract three times with 95% ethanol under reflux, combine and concentrate the filtrates of the three times, add water to dilute to ethanol concentration of 80%, then extract three times with petroleum ether, recover the solution until it has no alcohol smell, and obtain the extract. The extract was dissolved in water, and then extracted with ethyl acetate to obtain an extract, which was inoculated with 5% NaHCO 3 The aqueous solution was extracted three times, and finally washed with water until neutral, concentrated and dried, ground and sieved to obtain powdered ferulic sesquiterpene lactone.

[0022] 2. The killing effect of ferulic sesquiterpene lactones on adults and children of Schistosoma japonicum cultured in vitro

[0023] Method: 18 days after the young mice were infected with Schistosoma japonicum cercariae, the larvae of Schistosoma japonicum were collected by hepatic portal v...

Embodiment 2

[0048] According to the above experimental results, it has been verified that ferulic sesquiterpene lactone has an efficient and excellent killing effect on Schistosoma japonicum, and can directly act in vivo and in vitro, so it can be prepared as an anti-schistosomiasis drug, as follows:

[0049] Grind and dry the extracted Ferulic sesquiterpene lactone and sieve it to disperse it into a uniform powder, then add auxiliary materials carboxymethyl starch sodium (CMS-Na), β-cyclodextrin, hydroxide Aluminum gel, talcum powder, magnesium stearate and stevioside are mixed evenly and directly compressed into tablets.

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Abstract

The invention discloses application of ferula asafoetida sesquiterpene lactone in preparation of an anti-schistosomiasis drug, wherein the concentration of the ferula asafoetida sesquiterpene lactone is 10-100 mg / mL; and schistosoma japonicum is schistosoma japonicum. It is verified for the first time that the ferula asafoetida sesquiterpene lactone derived from ferula asafoetida has the effect of killing adults and juvenile insects of the schistosoma japonicum in vivo and in vitro; the highest insect reduction rate in vivo can reach 61.26%; furthermore, the female reduction effect is obvious; meanwhile, the ferula asafoetida sesquiterpene lactone further has the effect of efficiently killing eggs of the schistosoma japonicum in vivo; that is, the ferula asafoetida sesquiterpene lactone has a remarkable killing effect on different development stages of the schistosoma japonicum, so that the ferula asafoetida sesquiterpene lactone can be prepared into the anti-schistosomiasis drug; an important theoretical basis is provided for developing a novel schistosomiasis prevention and control drug; and the ferula asafoetida sesquiterpene lactone has wide market application prospect and application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of ferulic sesquiterpene lactone in the preparation of anti-schistosomiasis drugs. Background technique [0002] Schistosomiasis is a zoonotic, serious and easily neglected parasitic disease caused by schistosome cercariae infecting humans or other mammals. It is also one of the six major tropical diseases identified by WHO. According to the statistics of the World Health Organization, as of 2016, at least 76 countries around the world have found schistosomiasis, and nearly 200 million people need preventive treatment for schistosomiasis. There are mainly 5 kinds of schistosomiasis that are widely prevalent and seriously harmful, namely Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium, Schistosomiasis schistosomiasis and schistosomiasis intercalatum. Schistosomiasis is the pathogen of Schistosomiasis which is prevalent in my countr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P33/12
CPCA61K36/23A61P33/12A61K2236/33A61K2236/35A61K2236/51Y02A50/30
Inventor 赵红梅陈英琼苏明杰
Owner YANGTZE UNIVERSITY
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