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Triterpenoid saponin compound with effect of improving glucose and lipid metabolism disorder as well as preparation and application of triterpenoid saponin compound

A technology of triterpenoid saponins and compounds, applied in the field of triterpenoid saponins, can solve the problems of unclear hypoglycemic action mechanism, unclear composition and structure of active substances, etc.

Active Publication Date: 2021-09-14
SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition and structure of the main active substances for its health effects are not clear, and the mechanism of hypoglycemic action is also unclear

Method used

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  • Triterpenoid saponin compound with effect of improving glucose and lipid metabolism disorder as well as preparation and application of triterpenoid saponin compound
  • Triterpenoid saponin compound with effect of improving glucose and lipid metabolism disorder as well as preparation and application of triterpenoid saponin compound
  • Triterpenoid saponin compound with effect of improving glucose and lipid metabolism disorder as well as preparation and application of triterpenoid saponin compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0044] The preparation of embodiment 1 triterpene saponin new compound

[0045] 1.1. Plant source and identification

[0046] The fruit sample of bitter gourd (Momordica charantia L.), a plant material used for extraction, is green striped long body bitter gourd, which was purchased from Guangzhou City, Guangdong Province.

[0047] 1.2. Extraction and separation

[0048] (1) fresh balsam pear is washed, deseeded, sliced, dried, pulverized and passed through a 40-mesh sieve to obtain balsam pear dry powder;

[0049] (2) Bitter melon dry powder is extracted at room temperature with 70% ethanol by volume according to a solid-liquid ratio of 1:3 (g:mL), to obtain a bitter gourd triterpene extract;

[0050] (3) The bitter gourd triterpene extract was mixed with petroleum ether, ethyl acetate, and n-butanol in a volume ratio of 1:3 in sequence, then shaken for 10 minutes, and left to stand at room temperature for 30 minutes in a separatory funnel to separate the triterpenes. The ...

Embodiment 2 3

[0062] Example 2 New triterpenoid saponin compound (23R, 25E)-3β-hydroxy-23-methoxycucurbita-6, 25-dien-5β, 19-olide3-O-β-D-allopyranoside and Momordicoside G improve glucose and lipid metabolism disorders Function analysis

[0063] 1. Hepatic gluconeogenesis inhibitory activity

[0064] In this example, the hepatic parenchymal cells of primary isolated SD rats (purchased from the Experimental Animal Center of Southern Medical University) were used as a model, and the traditional Chinese medicine traditional Chinese medicine for hypoglycemic berberine (Berberine) was used as a positive control to evaluate new triterpenoid saponin compounds (23R, 25E )-3β-hydroxy-23-methoxycucurbita-6,25-dien-5β,19-olide3-O-β-d-allopyranosi de and Momordicoside G, and compositions thereof in different ratios (new triterpene saponin compounds: Momordicoside G= 1:0.5, 1:1.0, 1:1.5) on hepatic gluconeogenesis, further illustrating the beneficial effects of the present invention. The process is a...

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Abstract

The invention belongs to the technical field of natural medicines, and particularly relates to a triterpenoid saponin compound with an effect of improving glucose and lipid metabolism disorder as well as preparation and application of the triterpenoid saponin compound. The new triterpenoid saponin compound is separated from a Momordica charantia L. for the first time, research on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model finds that the new triterpenoid saponin compound has glycolipid metabolism regulating activity, and after the new triterpenoid saponin compound is matched with a known triterpenoid saponin compound Momordicoside G, ound is improved. the glycolipid metabolism regulating activity is obviously higher than that of a single compound under the same dosage, so that the novel triterpenoid saponin compound and the compound thereof can be used for improving the glycolipid metabolism disorder, and a new way is provided for treating diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a triterpene saponin compound capable of improving glucose and lipid metabolism disorders and its preparation and application. Background technique [0002] Diabetes is a common chronic non-communicable disease that has become a serious public health problem worldwide. The persistent high blood sugar in diabetic patients will lead to a series of microvascular or macrovascular complications with high probability, involving the eyes, kidneys, heart and nervous system, etc. Economic burden and disease burden. In recent years, diabetes has become a type of chronic disease that is second only to tumor diseases and cardiovascular diseases, and is more harmful to human health and safety. At present, the α-glucosidase inhibitor acarbose tablets and insulin secretion-stimulating agents are widely used clinically as pharmaceutical preparations for the treatment of d...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K31/585A61P3/10A61P3/06A23L33/11
CPCC07J71/0005A61P3/10A61P3/06A23L33/11A23V2002/00A23V2200/3262A23V2200/328A23V2250/21A23V2300/02A23V2300/14A23V2300/38A61K36/42A61K2236/00C07D407/12
Inventor 邓媛元张名位贾栩超李萍赵志浩周鹏飞刘光张雁唐小俊魏振承
Owner SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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