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Orthopedic medical binding material with antibacterial effect and preparation method of medical binding material

An adhesive material and orthopaedic technology, applied in the field of medical materials, can solve the problems of small adhesive force, difficult to bond and fix bone fragments, poor water solubility, and high brittleness, and achieve excellent antibacterial and bactericidal effects, improve compression resistance, and good The effect of compressive strength

Active Publication Date: 2021-09-10
刘长城
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional calcium phosphate bone cement has disadvantages such as high brittleness, poor water solubility (blood solubility), insufficient mechanical properties, and slow degradation, which limit its wide application in clinical practice, and composite calcium phosphate bone cement will help improve it. performance
Currently commonly used adhesive materials have their own advantages and disadvantages. Although chemical adhesive materials have strong adhesive force, they are extremely difficult to absorb in the body and often have certain toxic and side effects; protein adhesive materials may cause strong allergic and immune reactions. Or infected with viruses, the adhesive force is too small to bond and fix bone blocks, and it is difficult for a single material to meet the needs of bone tissue repair for the complex structure of bone tissue

Method used

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  • Orthopedic medical binding material with antibacterial effect and preparation method of medical binding material

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Embodiment 1

[0014] A preparation method of an orthopedic medical adhesive material with antibacterial effect, comprising the following raw materials in parts by weight: 45 parts of self-made modified calcium phosphate bone cement, 12 parts of n-octyl α-cyanoacrylate, 15 parts of dopamine, alginic acid 4 parts of sodium, 3 parts of lecithin, 5 parts of 3,4-dihydroxyphenylalanine, 11 parts of collagen, 8 parts of chitosan, 3 parts of arthine, 3 parts of phenylalanine, 3-p-chloro 3 parts of phenoxy-1,2-propanediol, 2.5 parts of β-cyclodextrin.

[0015] Wherein, the self-made modified calcium phosphate bone cement is prepared by the following method: adding calcium phosphate bone cement, L-alanine, β-cyclodextrin and butyl acrylate into a ball mill, then ball milling for 3 hours, and then adding two Methicone and sodium carboxymethylcellulose ball milled for 2 hours; calcium phosphate cement, L-alanine, β-cyclodextrin, butyl acrylate, dimethylsiloxane and sodium carboxymethylcellulose The ma...

Embodiment 2

[0021] A preparation method of an orthopedic medical adhesive material with antibacterial effect, comprising the following raw materials in parts by weight: 60 parts of self-made modified calcium phosphate bone cement, 18 parts of n-octyl α-cyanoacrylate, 24 parts of dopamine, alginic acid 10 parts of sodium, 6 parts of lecithin, 10 parts of 3,4-dihydroxyphenylalanine, 16 parts of collagen, 15 parts of chitosan, 5 parts of arthine, 5 parts of phenylalanine, 3-p-chloro 6 parts of phenoxy-1,2-propanediol, 5 parts of β-cyclodextrin.

[0022] Wherein, the self-made modified calcium phosphate bone cement is prepared by the following method: adding calcium phosphate bone cement, L-alanine, β-cyclodextrin and butyl acrylate into a ball mill, then ball milling for 5 hours, and then adding two Methicone and sodium carboxymethylcellulose ball milled for 3 hours; calcium phosphate cement, L-alanine, β-cyclodextrin, butyl acrylate, dimethylsiloxane and sodium carboxymethylcellulose The m...

Embodiment 3

[0028] A preparation method of an orthopedic medical adhesive material with antibacterial effect, comprising the following raw materials in parts by weight: 50 parts of self-made modified calcium phosphate bone cement, 14 parts of n-octyl α-cyanoacrylate, 18 parts of dopamine, alginic acid 6 parts of sodium, 4 parts of lecithin, 7 parts of 3,4-dihydroxyphenylalanine, 13 parts of collagen, 10 parts of chitosan, 4 parts of amino acid, 4 parts of phenylalanine, 3-p-chloro 4 parts of phenoxy-1,2-propanediol, 3 parts of β-cyclodextrin.

[0029] Wherein, the self-made modified calcium phosphate bone cement is prepared by the following method: adding calcium phosphate bone cement, L-alanine, β-cyclodextrin and butyl acrylate into a ball mill, then ball milling for 4 hours, and then adding two Methicone and sodium carboxymethylcellulose ball milled for 2.5 hours; calcium phosphate cement, L-alanine, β-cyclodextrin, butyl acrylate, dimethylsiloxane and sodium carboxymethylcellulose Th...

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Abstract

The invention discloses an orthopedic medical bonding material with an antibacterial effect and a preparation method thereof, and the orthopedic medical bonding material comprises the following raw materials in parts by weight: 45-60 parts of self-made modified calcium phosphate bone cement, 12-18 parts of N-octyl-alpha -cyanoacrylate, 15-24 parts of dopamine, 4-10 parts of sodium alginate, 3-6 parts of lecithin, 5 to 10 parts of 3, 4-dihydroxyphenylalanine, 11 to 16 parts of collagen, 8 to 15 parts of chitosan, 3 to 5 parts of tyrosine, 3 to 5 parts of phenylalanine and 3 to 6 parts of 3-p-chlorophenoxy-1, 2-propylene glycol. The medical binding material for the orthopedics department prepared by the invention has excellent antibacterial and bactericidal effects and good compressive strength.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an orthopedic medical adhesive material with antibacterial effect and a preparation method thereof. Background technique [0002] Humans have a long history of applying medical adhesive materials. In recent decades, in order to reduce the complexity of surgery, medical adhesives have been developed rapidly and widely used. In surgical operations, medical adhesives are used for local bonding and repair of certain organs and tissues, and to prevent bleeding from capillaries at sutures after surgery; in gynecology, it is used to block the fallopian tubes to complete ligation; in dentistry, it is used for tooth repair; orthopedic surgery The combination and positioning of bones and joints. Adhesives for bone require good biocompatibility. Degradability, no visceral toxicity and cytotoxicity, no carcinogenic and teratogenic effects, and rapid adhesion can be ac...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02A61L24/08A61L24/10
CPCA61L24/0015A61L24/001A61L24/02A61L24/08A61L24/102A61L2300/216A61L2300/404C08L5/08C08L5/04C08L5/16
Inventor 江霞妹
Owner 刘长城
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