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Biomedical poly(4-hydroxybutyrate) absorbable surgical suture and preparation method thereof

Pending Publication Date: 2021-09-10
青岛博远高分子材料研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The absorbable sutures produced and sold in China are mainly catgut and collagen threads. The technology is relatively simple, but the problems of manufacturing process, antigenicity and fast degradation rate have been difficult to solve.
However, ring-opening polymerization of five-membered ring lactones has been a major challenge in chemical synthesis, and γ-BL has long been considered a non-polymerizable monomer in both textbooks and literature.

Method used

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  • Biomedical poly(4-hydroxybutyrate) absorbable surgical suture and preparation method thereof
  • Biomedical poly(4-hydroxybutyrate) absorbable surgical suture and preparation method thereof
  • Biomedical poly(4-hydroxybutyrate) absorbable surgical suture and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A biomedical P4HB absorbable surgical suture is made of the following raw materials in parts by weight:

[0030] Biomedical grade P4HB (molecular weight 158,000, melt index 2.5) 96 parts, P3HB 1.5 parts, VC 2 parts, epoxy polymer chain extender ADR-4468 0.5 parts.

[0031] The method for preparing the above-mentioned P4HB absorbable surgical suture comprises the following steps:

[0032] Step 1. Weigh P4HB, P3HB, ADR-4468, and VC according to the formula and put them into a high-speed mixer, stir and blend evenly, and prepare the modified P4HB through a twin-screw extruder from the obtained blend. The processing temperature of the twin-screw extruder is 80°C, 100°C, 100°C, 120°C, 120°C, 120°C, 100°C, the screw speed is 150rpm, the screw combination is high shear, and the cooling water temperature is 7°C.

[0033] Step 2: Add the modified P4HB particles into the melt spinning process, the processing temperature is 80°C, 100°C, 120°C, 150°C, 150°C, 150°C, the screw speed...

Embodiment 2

[0036] A biomedical P4HB absorbable surgical suture is made of the following raw materials in parts by weight:

[0037] Biomedical grade P4HB (molecular weight 158,000, melt index 2.5) 96 parts, PDO 1 part, VE 2 parts, epoxy polymer chain extender ADR-4468 1 part.

[0038] The method for preparing the above-mentioned P4HB absorbable surgical suture comprises the following steps:

[0039] Step 1. Weigh P4HB, PDO, ADR-4468, and VE according to the formula and put them into a high-speed mixer, stir and blend evenly, and prepare the modified P4HB through a twin-screw extruder from the obtained blend. The processing temperature of the twin-screw extruder is 80°C, 100°C, 100°C, 120°C, 130°C, 130°C, 120°C, the screw speed is 150rpm, the screw combination is high shear, and the cooling water temperature is 7°C.

[0040] Step 2: Add the modified P4HB particles into the melt spinning process, the processing temperature is 80°C, 100°C, 120°C, 150°C, 150°C, 150°C, the screw speed is 30rp...

Embodiment 3

[0043] A biomedical P4HB absorbable surgical suture is made of the following raw materials in parts by weight:

[0044] Biomedical grade P4HB (molecular weight 158,000, melt index 2.5) 96.5 parts, cellulose nanocrystal 1 part, carotene 2 parts, maleic anhydride 0.5 parts.

[0045] The method for preparing the above-mentioned P4HB absorbable surgical suture comprises the following steps:

[0046] Step 1. Weigh P4HB, cellulose nanocrystals, carotene, and maleic anhydride according to the formula and put them into a high-speed mixer, stir and blend evenly, and prepare the modified P4HB through a twin-screw extruder from the obtained blend. The processing temperature of the twin-screw extruder is 80°C, 100°C, 100°C, 120°C, 120°C, 120°C, 100°C, the screw speed is 150rpm, the screw combination is high shear, and the cooling water temperature is 7°C.

[0047] Step 2: Add the modified P4HB particles into the melt spinning process, the processing temperature is 80°C, 100°C, 120°C, 150...

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Abstract

The invention discloses a biomedical poly(4-hydroxybutyrate) absorbable surgical suture and a preparation method thereof, belongs to the technical field of preparation of biomedical absorbable surgical sutures, and provides a method for preparing a high-strength, functional and absorbable surgical suture by using domestic autonomously innovated biomedical raw materials and a process technology. The technical problem that most biomedical materials in China depend on import and medical equipment preparation is solved, and foreign monopoly is broken fundamentally. The biomedical poly(4-hydroxybutyrate) absorbable surgical suture is prepared from the raw materials in parts: 90-95 parts of biomedical grade poly(4-hydroxybutyrate)(P4HB), 1-3 parts of a nucleation inducer, 1-2 parts of a natural antioxidant and 0-2 parts of a chain extender. The preparation method comprises the following steps that firstly, a P4HB modified material is prepared by adopting proper process temperature and shearing conditions, and then surgical suture wires with different specifications are prepared by adopting a melt spinning method through two-stage stretching and surface coating spraying. Compared with a P4HB suture obtained by an imported biological fermentation method, the biomedical poly(4-hydroxybutyrate) absorbable surgical suture has similar mechanical properties, is low in cost and stable in quality, and has more excellent human body compatibility and in-vivo degradability.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a novel bio-based poly(4-hydroxybutyrate) absorbable suture and a preparation method thereof. Background technique [0002] At present, surgical sutures in clinical application are divided into two categories: absorbable and non-absorbable. Absorbable surgical sutures can not only provide temporary supports and barriers for the body, but also avoid rejection in the body through degradation and absorption. Infectious inflammation and other adverse reactions, while reducing the risk of secondary surgery, compared with other surgical sutures in clinical medicine, has obvious advantages, and is the main development direction of surgical sutures in the future. Currently clinically synthesized absorbable polyester surgical suture materials include polyglycolide (PGA), glycolide-caprolactone copolymer, glycolide-lactide copolymer, polydioxane Hexanone (PDO),...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/14A61L17/00D06M13/207D01F6/92D01F1/10D06M101/32
CPCA61L17/105A61L17/145A61L17/005D06M13/207D01F6/92D01F1/10D06M2101/32A61L2300/216A61L2300/404A61L2300/41C08L67/04
Inventor 李志波阚泽沈勇
Owner 青岛博远高分子材料研究院有限公司
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