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Application of puerarin in preparation of medicines for preventing and/or treating irritable bowel syndrome

A technology of irritable bowel syndrome and puerarin, which is applied in the field of medicine and health, and can solve problems that have not been reported.

Active Publication Date: 2021-09-10
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, puerarin has not been reported for the treatment of irritable bowel syndrome.

Method used

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  • Application of puerarin in preparation of medicines for preventing and/or treating irritable bowel syndrome
  • Application of puerarin in preparation of medicines for preventing and/or treating irritable bowel syndrome
  • Application of puerarin in preparation of medicines for preventing and/or treating irritable bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Embodiment 1 puerarin tablet

[0104] 1. Prepare raw materials according to the following ratio

[0105]

[0106] Mix the puerarin and the starch evenly, make granules, add talcum powder and magnesium stearate, mix evenly, press into tablets, each tablet is 0.2g.

Embodiment 2

[0107] Embodiment 2 puerarin capsules

[0108] 1. Prepare raw materials according to the following ratio

[0109] Puerarin (purity greater than 98%) 100g

[0110] Vitamin C 600g

[0111] Starch 1000g

[0112] Mix puerarin, vitamin C and starch evenly and pack into capsules, 0.2g per capsule.

Embodiment 3

[0113] Embodiment 3 puerarin granules

[0114] Puerarin (purity greater than 98%) 50g

[0115] Vitamin C 600g

[0116] Sucrose powder 5000g

[0117] Mix puerarin, vitamin C and sucrose powder evenly to make granules and pack them into bags, 5g per bag.

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Abstract

The invention discloses an application of puerarin for preventing, treating and / or relieving irritable bowel syndrome. The puerarin can restore retarded cell cycles and promote the proliferation of intestinal epithelial cells by up-regulating the level of phosphorylated extracellular regulatory protein kinase (p-ERK). The puerarin can participate in the repair of the intestinal epithelial barrier by up-regulating expression of tight junction protein (occulting), and inhibit the hyperfunction of the hypothalamic-pituitary-adrenal axis (HPA axis) by down-regulating expression of hypothalamic corticotropin release factor (CRF1) receptor protein, and improve the gastrointestinal motility and visceral hypersensitivity. Tests prove that puerarin has a remarkable curative effect on the irritable bowel syndrome, takes effect quickly and has small side effects. The puerarin is an efficient, safe, stable medicine with extensive sources for treating the irritable bowel syndrome. The puerarin of the invention provides a new medicine source for preventing and treating the irritable bowel syndrome and complications thereof.

Description

technical field [0001] The invention belongs to the field of medicine and health, and relates to a medicine or health care product for preventing, treating and / or alleviating gastrointestinal diseases, in particular to an active ingredient of the traditional Chinese medicine Pueraria lobata in the prevention and treatment of irritable bowel syndrome. Application in medicine or health food. Background technique [0002] In today's society, people's study, work, and life pressure are gradually increasing, irregular living habits, unbalanced diet structure, long-term tension, anxiety, depression, etc., often lead to gastrointestinal dysfunction, brain-intestinal regulation disorder and intestinal Irritable bowel syndrome (irritable bowel syndrome, IBS) is one of them, which is a group of continuous or intermittent attacks, with abdominal pain, bloating, changes in bowel habits and / or stool characteristics as clinical manifestations , and intestinal dysfunction in the absence o...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/00A23L33/10
CPCA61K31/352A61P1/00A23L33/10A23V2002/00A23V2200/32A23V2250/2116
Inventor 王强松崔元璐张文艳王贵芳张燕
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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