Inhalant used for inhibiting coronavirus, and preparation method and application of inhalant

Abstract

The invention relates to an inhalant used for inhibiting coronavirus, and a preparation method and application of the inhalant, and belongs to the technical field of pharmaceutical preparations. The inhalant comprises Remdesivir and / or a pharmaceutically acceptable salt thereof. According to the inhalant used for inhibiting the coronavirus, due to adoption of small-dose pulmonary administration,effective pulmonary administration concentration can be achieved when micronized or aerosolized Remdesivir is inhaled, the coronavirus, especially the novel coronavirus, can be effectively inhibited, the defects of a narrow treatment window and poor safety in the prior art are overcome, a small dosage is given for multiple times, so that the inhalant can be accumulated in the lung so as to form an effective virus inhibition effect, a curative effect can be improved or the dosage of the Remdesivir is reduced, and potential side effects are reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an inhalant for inhibiting coronavirus, its preparation method and application. Background technique [0002] Coronaviruses are enveloped, non-segmented, positive-sense, single-stranded RNA viruses with genome sizes ranging from 26 to 32 kb, the largest known RNA virus genomes. The virion has a genomic RNA and a phosphorylated nucleocapsid (N) protein wrapped in a phospholipid bilayer and covered by two different types of spike proteins: the spike glycoprotein trimer (S ) and hemagglutinin esterase (HE) present in some CoVs. The membrane (M) protein, a type III transmembrane glycoprotein, and the envelope (E) protein are located between the S protein in the viral envelope. [0003] In recent years, coronaviruses have periodically emerged around the world. The unexpected emergence of the coronavirus, its ease of transmission, and its catastrophic consequence...

AI Technical Summary

Problems solved by technology

[0008] In summary, remdesivir injection has a good curative effect on coronaviruses, especially novel coronaviruses, but due to its narrow therapeutic window and low selectivity of target organs for systemic administration, there is a greater risk in safety, while Through repeated administration of small doses to the lungs, an effective inhibitory virus concentration can be formed in the lungs, thus making it safe and effective at low doses

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