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Preparation method of self-adhesive hydrogel material for DIW customized bolus

A hydrogel, self-adhesive technology, used in X-ray/γ-ray/particle irradiation therapy, etc., can solve the problems of air gap between bolus and skin, poor performance, etc., achieve fast rheological properties, good mechanical strength, inhibition The effect of air gaps

Pending Publication Date: 2021-09-03
FOURTH MILITARY MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to aim at the problems existing in the prior art, to provide a kind of preparation method for the self-adhesive hydrogel material of DIW (ink direct writing technology) custom-made bolus, wherein DIW technology is a kind of low cost, simple and easy The current 3D printing technology, using the hydrogel material prepared by the present invention combined with DIW, can effectively solve the problem of poor technical performance of existing materials in 3D printing bolus and the problem of re-appearing air gaps between bolus and skin during radiotherapy

Method used

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  • Preparation method of self-adhesive hydrogel material for DIW customized bolus

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Embodiment 1

[0019] A method for preparing a self-adhesive hydrogel material for DIW custom bolus, comprising the following steps:

[0020] Step 1. Dissolve 0.2 g of dopamine hydrochloride powder in 100 ml of ammonia solution (pH=8-9), and then stir in the air for 20 minutes to form a pre-polymerized solution of dopamine;

[0021] Step 2. Dissolve 6g of sodium alginate and 20g of acrylic acid in the above-mentioned dopamine prepolymerization solution, adjust the pH of the solution to 7-8 with ammonia water, and then add 0.01g of cross-linking agent N,N'-methylenebisacrylamide (MBA) and 1g photoinitiator 2959, stirred for 2h to make the mixture uniform;

[0022] Step 3, add 1ml of Fe(NO 3 ) 3 aqueous solution, Fe(NO 3 ) 3 The dosage is 0.3g, vigorously stirred at room temperature for more than 5h, and then left to stand at 5°C for 48h to form a physically cross-linked gel preform, namely "gel ink";

[0023] Step 4. Use a wavelength of 365nm and an intensity of 8mW / cm at room temperatur...

Embodiment 2

[0026]A method for preparing a self-adhesive hydrogel material for DIW custom bolus, comprising the following steps:

[0027] Step 1. Dissolve 0.3 g of dopamine hydrochloride powder in 100 ml of ammonia solution (pH=8-9), and then stir in the air for 20 minutes to form a pre-polymerized solution of dopamine;

[0028] Step 2. Dissolve 5g of sodium alginate and 20g of acrylic acid in the above-mentioned dopamine prepolymerization solution, adjust the pH of the solution to 7-8 with ammonia water, and then add 0.02g of cross-linking agent N,N'-methylenebisacrylamide (MBA) and 2g photoinitiator 2959, stirred for 2h to make the mixed solution uniform;

[0029] Step 3, add 1ml of Fe(NO 3 ) 3 aqueous solution, Fe(NO 3 ) 3 The dosage is 0.4g, vigorously stirred at room temperature for more than 5h, and then left to stand at 5°C for 48h to form a physically cross-linked gel preform, namely "gel ink";

[0030] Step 4. Use a wavelength of 365nm and an intensity of 8mW / cm at room temp...

Embodiment 3

[0033] A method for preparing a self-adhesive hydrogel material for DIW custom bolus, comprising the following steps:

[0034] Step 1. Dissolve 0.32 g of dopamine hydrochloride powder in 80 ml of ammonia solution (pH=8-9), and then stir in the air for 20 minutes to form a pre-polymerized solution of dopamine;

[0035] Step 2. Dissolve 3g of sodium alginate and 16g of acrylic acid in the above-mentioned dopamine pre-polymerization solution, adjust the pH of the solution to 7-8 with ammonia water, and then add 0.003g of cross-linking agent N,N'-methylenebisacrylamide (MBA) and 0.32g photoinitiator 819, stir 2h to make the mixed solution uniform;

[0036] Step 3, add 1ml of Fe(NO 3 ) 3 aqueous solution, Fe(NO 3 ) 3 The dosage is 0.06g, vigorously stirred at room temperature for more than 5h, and then left to stand at 5°C for 48h to form a physically cross-linked gel preform, namely "gel ink";

[0037] Step 4. Use a wavelength of 365nm and an intensity of 8mW / cm at room tempe...

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Abstract

The invention relates to a preparation method of a self-adhesive hydrogel material for DIW customized bolus, which comprises the following steps: firstly, forming a dopamine prepolymerization solution in an ammonia water solution by dopamine hydrochloride molecules, then mixing with acrylic acid, sodium alginate, a cross-linking agent and a photoinitiator, forming a gel preform under the cross-linking action of Fe < 3 + >, irradiating by an ultraviolet lamp, obtaining a polyacrylic acid / alginate double-network hydrogel crude product with coexistence of physical crosslinking and chemical crosslinking, finally, soaking the hydrogel crude product in deionized water to achieve purification balance, and obtaining the self-adhesion hydrogel material for DIW customized bolus. The hydrogel material has good strength, flexibility and self-adhesion, can effectively solve the problems that an existing material in 3D printing of the bolus is poor in performance and an air gap appears between the bolus and the skin again in the radiotherapy process, is an ideal material for manufacturing the bolus based on DIW, and is suitable for clinical application and popularization.

Description

technical field [0001] The content of the present invention belongs to the technical field of preparation of medical radiotherapy tissue compensator materials, and specifically relates to a method for preparing self-adhesive hydrogel materials used in DIW (direct ink writing technology) customized bolus (radiotherapy tissue compensators). Background technique [0002] The high-energy X-rays or γ-rays used in radiotherapy (radiotherapy) can effectively kill tumor cells, which is one of the important means of treating malignant tumors and has a prominent role and status in cancer treatment. In radiotherapy after modified radical mastectomy for skin cancer, parotid gland cancer, or breast cancer, due to the dose building effect of high-energy rays, the irradiation dose of the above superficial lesions is insufficient, and tissue compensators need to be added to increase the local exposure dose. The so-called radiotherapy tissue compensator (bolus) refers to the general term for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08F251/00C08F220/06C08F222/38C08F2/48A61N5/10C08L51/02C08L79/04
CPCC08J3/075C08J3/246C08F251/00C08F2/48A61N5/10C08J2351/02C08J2479/04A61N2005/1096C08F220/06C08F222/385
Inventor 吕博后振中
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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