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Veterinary long-acting compound amoxicillin oil suspension injection and preparation method thereof

A technology of amoxicillin oil and amoxicillin sodium, applied in the field of veterinary long-acting compound amoxicillin oil suspension injection and its preparation, to avoid antibiotic drug residues, shorten drug withdrawal period, and improve slow onset effect

Active Publication Date: 2022-05-06
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Sesquiterpenes are natural terpenoids whose molecular skeleton is composed of 3 isoprene units. They have a wide range of biological activities and are important raw materials in the pharmaceutical, food, and cosmetic industries. However, no sesquiterpenes have been prepared yet. Report on long-acting compound amoxicillin oil injection for veterinary use

Method used

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  • Veterinary long-acting compound amoxicillin oil suspension injection and preparation method thereof
  • Veterinary long-acting compound amoxicillin oil suspension injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: A kind of veterinary long-acting compound amoxicillin oil suspension injection

[0033] Amoxicillin trihydrate 56g, amoxicillin sodium 16g, potassium clavulanate 16g, Inner Mongolia dandelion lactone A48g, aluminum stearate 10g, vitamin E 5g and soybean oil for injection 1000mL were prepared according to the following method:

[0034] (1) After weighing each raw material according to the amount, amoxicillin trihydrate, amoxicillin medicinal salt, potassium clavulanate, and Inner Mongolia dandelion lactone A were respectively crushed through an 80-mesh sieve, and set aside;

[0035] (2) Heat a quarter of the volume of injection oil to 115°C, keep it for 30 minutes, let it cool to 50°C, add suspending agent and mix well, then heat it to 115°C again, let it cool to 50°C again, add all The amount of amoxicillin trihydrate, half of the amount of amoxicillin sodium, half of the amount of clavulanate potassium and half of the amount of Inner Mongolia dandelion la...

Embodiment 2

[0037] Embodiment 2: A kind of veterinary long-acting compound amoxicillin oil suspension injection

[0038] Amoxicillin trihydrate 56g, amoxicillin sodium 16g, potassium clavulanate 16g, Inner Mongolia dandelion lactone A48g, aluminum stearate 10g, vitamin E 5g and refined coconut oil 1000mL, prepared according to the following method:

Embodiment 3

[0039] Embodiment 3: A kind of veterinary long-acting compound amoxicillin oil suspension injection

[0040] Amoxicillin trihydrate 48g, amoxicillin sodium 8g, sulbactam 8g, Inner Mongolia dandelion lactone A 40g, aluminum stearate 10g, vitamin E 5g and soybean oil for injection 1000mL were prepared according to the method in Example 1.

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Abstract

The present invention relates to a long-acting compound amoxicillin oil suspension injection for animals and a preparation method thereof. Salt, β-lactamase inhibitor, sesquiterpenoids, suspending agent, antioxidant and injection oil, on the basis of satisfying the slow release of amoxicillin, it obviously shortens the time limit of amoxicillin The onset time, and the use of sesquiterpenoids, especially mongolicactone A, significantly enhanced the antibacterial effect of long-acting compound amoxicillin oil suspension injection, thereby helping to reduce the antibacterial effect on the basis of ensuring the antibacterial effect. Dosage of moxicillin.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a veterinary long-acting compound amoxicillin oil suspension injection and a preparation method thereof. Background technique [0002] Amoxicillin, also known as amoxicillin or amoxycillin, is a commonly used semi-synthetic penicillin broad-spectrum β-lactam antibiotic for animals. It has strong bactericidal effect and strong ability to penetrate cell membranes. It is mainly used for For the treatment of bacterial infections and microbial infections in livestock, its existing dosage forms include capsules, tablets, granules, premixes, powders and injections. [0003] With the frequent occurrence of mixed infections in animal husbandry, conventional drug dosage forms have problems such as large fluctuations in therapeutic effect in the treatment and prevention of bacterial infectious diseases, and the need for long-term and multiple administrations, which not only increases th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K9/10A61K47/44A61K47/22A61P31/04A61K31/424A61K31/343
CPCA61K31/43A61K9/10A61K47/44A61K45/06A61K9/0019A61P31/04A61K31/424A61K31/343A61K47/22A61K2300/00
Inventor 赵宝凯闫琰朴洪宇许丹
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