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A kind of hydrophobic vanadium oxygen-organic molecular cage-based porous liquid for extracting l-tryptophan and its preparation method and application

A technology of organic molecules and tryptophan, applied in organic chemical methods, separation methods, solvent extraction, etc., to achieve the effect of mild operating conditions and simple processes

Active Publication Date: 2022-03-08
NANJING TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the synthesis of porous liquids using metal-organic molecular cages and ionic liquids as raw materials for the extraction of amino acids.

Method used

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  • A kind of hydrophobic vanadium oxygen-organic molecular cage-based porous liquid for extracting l-tryptophan and its preparation method and application
  • A kind of hydrophobic vanadium oxygen-organic molecular cage-based porous liquid for extracting l-tryptophan and its preparation method and application
  • A kind of hydrophobic vanadium oxygen-organic molecular cage-based porous liquid for extracting l-tryptophan and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of vanadyl-organic molecule cage-based porous liquid: Weigh 1g trihexyltetradecylphosphine chloride and 59.6mg hydoughnut-OH (hydoughnut-OH: trihexyltetradecylphosphine chloride molar ratio 1: 100), adding trihexyltetradecylphosphine chloride into a glass bottle, heating and stirring, and heating to 60°C. Slowly add the weighed hydoughnut-OH into trihexyltetradecylphosphine chloride, keep stirring until the mixture is uniform, and cool to room temperature. Add 20ml of acetonitrile to the above porous liquid, stir, centrifuge, remove ammonium chloride salt, and the remaining liquid is rotary evaporated at 50°C for 30 minutes to finally obtain the porous liquid, which is named hydoughnut-OH-IL.

[0038] Add 0.1g of hydoughnut-OH-IL into a 20ml glass bottle, then add 2ml of L-tryptophan aqueous solution (pH=6) with different concentrations, keep the temperature at 40°C, stir for 12h, centrifuge, separate and filter , to obtain the lower clarified amino acid aq...

Embodiment 2

[0043] Preparation of vanadyl-organic molecule cage-based porous liquid: Weigh 1g trihexyltetradecylphosphine chloride and 59.6mg hydoughnut-OH (hydoughnut-OH: trihexyltetradecylphosphine chloride molar ratio 1: 100), adding trihexyltetradecylphosphine chloride into a glass bottle, heating and stirring, and heating to 60°C. Slowly add the weighed hydoughnut-OH into trihexyltetradecylphosphine chloride, keep stirring until the mixture is uniform, and cool to room temperature. Add 20ml of acetonitrile to the above porous liquid, stir, centrifuge, remove ammonium chloride salt, and the remaining liquid is rotary evaporated at 50°C for 30 minutes to finally obtain the porous liquid, which is named hydoughnut-OH-IL.

[0044] Add 0.1g hydoughnut-OH-IL into a 20ml glass bottle, then add 2ml of L-tryptophan aqueous solution of different concentrations (adjust pH = 9), keep the constant temperature at 40°C, stir for 12h, centrifuge, separate, Filter to obtain the lower clarified amino...

Embodiment 3

[0048] Preparation of vanadyl-organic molecule cage-based porous liquid: Weigh 1g trihexyltetradecylphosphine chloride and 59.6mg hydoughnut-OH (hydoughnut-OH: trihexyltetradecylphosphine chloride molar ratio 1: 100), adding trihexyltetradecylphosphine chloride into a glass bottle, heating and stirring, and heating to 60°C. Slowly add the weighed hydoughnut-OH into trihexyltetradecylphosphine chloride, keep stirring until the mixture is uniform, and cool to room temperature. Add 20ml of acetonitrile to the above porous liquid, stir, centrifuge, remove ammonium chloride salt, and the remaining liquid is rotary evaporated at 50°C for 30 minutes to finally obtain the porous liquid, which is named hydoughnut-OH-IL.

[0049] Add 0.1g hydoughnut-OH-IL into a 20ml glass bottle, then add 2ml of L-tryptophan aqueous solution of different concentrations (adjust pH = 3), keep the constant temperature at 40°C, stir for 12h, centrifuge, separate, Filter to obtain the lower layer of clear ...

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Abstract

The invention discloses a hydrophobic vanadyl-organic molecular cage-based porous liquid for extracting L-tryptophan and its preparation method and application. By adding vanadyl-carboxyl metal-organic cage powder into the hydrophobic ionic liquid, After ion exchange, the counter cation in the cage and the anion in the ionic liquid form ammonium chloride salt, and by reducing the solubility of the ammonium chloride salt, it enters the crystallization region, removes the counter cation, and obtains pure vanadyl-organic molecular clathrate Porous liquid. The hydrophobic vanadyl-organic molecular cage-based porous liquid has the characteristics of diversified channels and adjustable pore size. The invention realizes the extraction of L-tryptophan in water by adjusting the pore structure of the vanadyl organic molecular cage. The invention is environmentally friendly, has mild operating conditions and simple process, and is an efficient and green method for separating L-tryptophan.

Description

technical field [0001] The invention belongs to the field of material preparation, and in particular relates to a hydrophobic vanadyl-organic molecule cage-based porous liquid for extracting L-tryptophan, a preparation method and application thereof. Background technique [0002] As the basic building blocks of life, amino acids have long played an important role in human and animal nutrition and health maintenance. Aromatic amino acids (phenylalanine L-Phe, tyrosine L-Tyr, tryptophan L-Trp ) as an essential amino acid for the human body, has an important effect on the human body, especially L-tryptophan, which plays an important role in the nutrition and pharmaceutical industries. [0003] The industrial synthesis of amino acids is by fermentation or chemoenzymatic processes, such as the enantioselective addition of L-Phe to trans-cinnamic acid by ammonia. Alternatively, amino acids can also be recovered by hydrolyzing non-feed protein waste. For example, poultry feather ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/00C07F9/54C07D233/58B01D11/04C07D209/20
CPCC07F9/00C07F9/5407C07D233/58B01D11/0492B01D11/04C07D209/20C07B2200/07
Inventor 张竹修乔旭张冰洁汤吉海杨宝林崔咪芬陈献费兆阳刘清
Owner NANJING TECH UNIV
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