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Pharmaceutical composition for treating epilepsy

A composition and drug technology, applied in the field of pharmaceutical compositions for the treatment of epilepsy, can solve problems such as weight loss, influence on cognition, etc., and achieve the effects of improving symptoms, promoting awakening, and good curative effect

Active Publication Date: 2021-08-24
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side effects of new antiepileptic drugs have been significantly reduced, but there are still many side effects, such as oxcarbazepine still has serious adverse reactions such as exfoliative dermatitis, topiramate affects cognition and causes weight loss, and the common side effect of lamotrigine is skin rash, etc.

Method used

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  • Pharmaceutical composition for treating epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, the preparation of medicine of the present invention

[0022] Recipe: Bupleurum bupleurum 10g, calamus 14g, Uncaria 21g, keel 21g, oyster 21g, peony root 21g, windproof 7g, fried silkworm 10g, earthworm 10g, licorice 3g.

[0023] Preparation method: take the above-mentioned herbs, add water to decoct, decoct twice in total, add 12 times v / w, ml / g of raw medicinal materials for decoction each time, and decoct for 2 hours, combine the two decoction liquids to obtain the product.

Embodiment 2

[0024] Embodiment 2, the preparation of medicine of the present invention

[0025] Recipe: 20g Bupleurum bupleurum, 26g Shichangpu, 39g Uncaria, 39g keel, 39g oyster, 39g white peony, 13g Fangfeng, 20g fried silkworm, 20g earthworm, 7g licorice.

[0026] Preparation method: take the above-mentioned herbs, add water to decoct, decoct 3 times in total, add 6 times the amount of raw medicinal materials v / w, ml / g each time and decoct for 1 hour, combine the two decoction liquids to obtain the product.

Embodiment 3

[0027] Embodiment 3, the preparation of medicine of the present invention

[0028] Recipe: 15g Bupleurum bupleurum, 20g Shichangpu, 20g Uncaria, 30g keel, 30g oyster, 20g white peony, 10g Fangfeng, 15g fried silkworm, 15g earthworm, 5g licorice.

[0029] Preparation method: take the above-mentioned herbs, add water to decoct, decoct twice in total, each time add 8 times the amount of raw medicinal materials v / w, ml / g to decoct for 1.5 hours, combine the two decoction liquids to obtain the product.

[0030] The beneficial effects of the present invention are illustrated below through test examples.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating epilepsy. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 10-20 parts of radix bupleuri, 14-26 parts of rhizoma acori graminei, 21-39 parts of uncaria, 21-39 parts of fossil fragments, 21-39 parts of oyster, 21-39 parts of white paeony root, 7-13 parts of divaricate saposhnikovia root, 10-20 parts of fried stiff silkworm, 10-20 parts of earthworm and 3-7 parts of liquorice. The composition disclosed by the invention has a remarkable effect on treating epilepsy, also has the effects of improving symptoms and reducing or controlling attack on part of intractable epilepsy, and can play a synergistic effect with anti-epilepsy western medicines when being used for an epileptic state, and meanwhile, can promote a patient to wake up. Compared with western medicines, the composition disclosed by the invention is safer, has no obvious toxic and side effects in long-term clinical application, has no side effects such as cognitive impairment, language impairment, dizziness and the like, has no teratogenesis effect, and has a clinical application prospect.

Description

technical field [0001] The invention specifically relates to a pharmaceutical composition for treating epilepsy. Background technique [0002] Epilepsy, commonly known as "shorn wind" or "epilepsy", is a recurrent chronic disease that requires long-term medication. Common antiepileptic drugs have many side effects, including gastrointestinal reactions and dizziness. , headache, drowsiness, double vision, ataxia of physical activity, etc., such as valproic acid side effects include weight gain, chronic cognition, memory, behavior changes, a few have severe liver toxicity, pancreatitis may occur, drugs There are obvious interactions between phenobarbital, chronic tissue and cognitive toxicity, and teratogenic effects; phenobarbital has sedative side effects, occasionally can cause connective tissue damage, withdrawal reactions, and teratogenic effects; ethosuximide occasionally has gastrointestinal reactions ; The initial dose of carbamazepine is prone to neurotoxicity, has m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K36/74A61P25/08A61P25/14A61P21/00A61K35/02A61K35/618A61K35/64A61K35/62
CPCA61K36/233A61K36/888A61K36/74A61K35/02A61K35/618A61K36/71A61K36/65A61K36/238A61K35/64A61K35/62A61K36/484A61P25/08A61P25/14A61P21/00A61K2236/331A61K2300/00Y02A50/30
Inventor 杨旭红郑丽君
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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