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Radiotherapy protective agent as well as preparation method and application thereof

A technology of protective agent and cross-linking method, which is applied in the direction of anti-inflammatory agent, anti-toxic agent, pharmaceutical formula, etc., to achieve the effect of improving utilization rate, good safety, and protecting gastrointestinal tract damage

Active Publication Date: 2021-08-10
INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, currently H 2 S is mainly used in the treatment of inflammatory diseases such as cardiovascular and cerebrovascular diseases, and there is no research in the field of radiotherapy protection, especially as a slow-release gas radiotherapy protective agent.

Method used

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  • Radiotherapy protective agent as well as preparation method and application thereof
  • Radiotherapy protective agent as well as preparation method and application thereof
  • Radiotherapy protective agent as well as preparation method and application thereof

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preparation example Construction

[0045] The invention provides a preparation method of a radiotherapy protective agent, comprising: mixing gelatin-based hydrogel and hydrogen sulfide donor GYY4137 at room temperature, and stirring to obtain a gelatin@hydrogen sulfide donor complex.

[0046] Specifically, the preparation method of the above-mentioned radiotherapy protective agent includes:

[0047] Step S1, synthesizing gelatin nanoparticles by cross-linking method, and then obtaining gelatin-based hydrogel by adjusting the pH value; specifically, step S1 includes:

[0048] S101, heating and dissolving gelatin powder in deionized water to obtain a first mixed solution;

[0049] S102. After the first mixed solution is filtered, glutaraldehyde solution is added, and stirred at room temperature for 5-10 minutes to obtain the second mixed solution;

[0050] S103. Add methanol / water mixed solution to the second mixed solution, and continue to stir for 0.8-1.5 hours to obtain the third mixed solution;

[0051] S10...

Embodiment 1

[0076] This embodiment provides a radiotherapy protective agent, the preparation method is as follows:

[0077] (1) Synthesis of gelatin nanoparticles and gelatin-based hydrogels by crosslinking

[0078] 0.5g of gelatin powder was dissolved in 100mL of deionized water, and dissolved at 50°C and 100rpm for 1h; the solution was filtered and then added with 4mL of 50% (wt) glutaraldehyde solution, stirred at room temperature for 5min at 1000rpm; then 50mL of methanol ( 45mL): water (5mL) = 9:1 (volume ratio) mixed solution, continue to stir for 1h; Next, add 400μL of concentrated hydrochloric acid with a mass concentration of 37%, continue to stir for 5h; finally add 500mL of acetone to the mixed solution, Seal and stand for 12 hours; remove excess liquid to obtain gelatin precipitation, and wash the gelatin precipitation with deionized water several times; then, add 5-10 mL of deionized water to stir the gelatin precipitation to obtain viscous gelatin nanoparticles, centrifuge t...

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Abstract

The invention discloses a radiotherapy protective agent as well as a preparation method and application thereof, belongs to the technical field of radiotherapy protection, and solves the problem of poor protection effect of gastrointestinal tract radiotherapy protective agents by oral administration in the prior art. The preparation method of the radiotherapy protective agent comprises the following steps: mixing gelatin-based hydrogel and a hydrogen sulfide donor GYY4137 at room temperature, and stirring the components to obtain a gelatin@hydrogen sulfide donor compound in a manner of regulating the pH value of gelatin nanoparticles synthesized by a crosslinking method to obtain the gelatin-based hydrogel, wherein the gelatin-based hydrogel wraps the hydrogen sulfide donor GYY4137 through electrostatic acting force and physical adsorption. The acid-sensitive sustained-release oral radiotherapy protective agent prepared by the invention can reduce physical damage to gastrointestinal tracts during radiotherapy. The invention provides a new thought and a new method for protection of patients after radiotherapy clinically.

Description

technical field [0001] The invention relates to the technical field of radiotherapy protection, in particular to an oral gas sustained-release radiotherapy protective agent and its preparation method and application. Background technique [0002] Malignant tumor is a frequently-occurring and common disease, which has seriously threatened human health. In my country, the cancer situation is particularly severe. At present, there are more and more tumor treatment methods, and the clinical tumor treatment methods mainly include surgery, radiotherapy and chemotherapy. In particular, the wide indications and high cure rate of radiotherapy make it an important position in tumor treatment. The therapeutic principle of radiation therapy (referred to as radiotherapy) is that high-energy ion rays (such as X-rays and γ-rays) directly interact with cellular DNA to cause DNA damage, or indirectly react with water molecules to generate free radical species (such as superoxide free radic...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K47/42A61K47/64A61K9/00A61P1/00A61P1/04A61P29/00A61P7/04A61P39/06
CPCA61K33/04A61K47/42A61K47/6435A61K9/0053A61P1/00A61P1/04A61P29/00A61P7/04A61P39/06
Inventor 尹文艳单鹏傅文慧
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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