Preparation method of cartilage regeneration scaffold material for sports wounds in orthopedics department

Abstract

The invention discloses a preparation method of a cartilage regeneration scaffold material for sports wounds in the orthopedics department, and belongs to the field of cartilage regeneration. The preparation method of the cartilage regeneration scaffold material for sports wounds in the orthopedics department comprises the following steps: coating a self-disaggregation pore-forming water-soluble layer outside superparamagnetic iron oxide nanoparticles; under the action of cell piece tissue fluid, the self-disaggregation pore-forming water-soluble layer is hydrolyzed, so that the surface of the regeneration scaffold material presents a porous form, and cartilage cells of the regeneration scaffold material are effectively induced to grow towards the interior of the regeneration scaffold material, so that the connectivity between the regeneration scaffold material and the cartilage of a patient is better; in addition, the cartilage powder particles and the cartilage tissue of the patient are effectively induced to jointly grow and proliferate towards the skeleton hollow sphere under the action of the skeleton hollow sphere, so that the repaired cartilage and the skeleton hollow sphere form a whole, and compared with the prior art, the cartilage repairing method has the advantages that the repairing cost is reduced, and the repairing efficiency is improved. The mechanical bearing capacity of the cartilage repaired by the regenerated scaffold material is obviously improved.

Description

technical field [0001] The invention relates to the field of cartilage regeneration, in particular to a method for preparing a cartilage regeneration scaffold material for orthopedic sports trauma. Background technique [0002] The current cartilage tissue engineering and regenerative medical technology materials can be divided into three generations according to the surgical method and design concept. The first generation technology uses periosteum or other cell carriers combined with chondrocytes to repair cartilage defects. The surgical method is to remove cartilage without destroying subchondral bone. , the cells of this technology are mainly derived from the late composite or synovial migration, and the nutrient supply of tissue engineered cartilage (repair material) is mainly supplied by synovial fluid. The scaffold material or carrier material of the second-generation technology has a certain activity or induction function. This scaffold can compound bone marrow strom...

AI Technical Summary

Problems solved by technology

The scaffold material or carrier material of the second-generation technology has a certain activity or induction function. This scaffold can compound bone marrow stromal stem cells, and can make the composite bone marrow stromal stem cells differentiate into chondrocytes. At the same time, this scaffold material can also induce cells from other sources. Form cartilage; this tissue-engineered cartilage has a stronger ability to form cartilage than the first-generation tissue-engineered cartilage, but the surgery still uses an implantation method that does not destroy the subchondral bone

[0003] The cartilage regeneration composite materials currently on the market are not high in mechanical strength, and the degradation cycle is too fast, which cannot play the role of a scaffold material, which will affect the normal movement of the patient after the cartilage is repaired, and even cause secondary damage.

Images