Method for detecting content of impurity 6-formylpterin in folic acid
A quantitative detection method and formylpterin technology, applied in the field of medicine, can solve problems such as low content and inability to detect, and achieve the effects of high sensitivity, high accuracy, and improved quality and drug safety.
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[0031] 1. Main instruments and reagents
[0032] (1) Instrument: high-performance liquid chromatography instrument: Agilent 1200 Series, equipped with a fluorescence detector, and the operating software of the liquid chromatography instrument is ChemStation software (RevB.04.01SP1) of Agilent Company.
[0033] (2) Reagents: ultrapure water, methanol (chromatographically pure), phosphoric acid (chromatographically pure).
[0034] 2. Experimental method
[0035] (1) Chromatographic conditions:
[0036] Chromatographic column: Agilent SB-CN column, 4.6×250mm, 5μm; flow rate: 1.0mL / min; column temperature: 35℃; injection volume: 35μL; mobile phase A: methanol-water containing 0.2% phosphoric acid=20:80 ; Mobile phase B: methanol-0.2% phosphoric acid water=45:55.
[0037] See Table 1 for gradient elution conditions.
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