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Repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and preparation method of repairing essence

A micro-environment and adaptogen technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as unsatisfactory treatment effect, single biological pathway, and aggravation of bacterial infection

Active Publication Date: 2021-07-06
浙江伊瑟奇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, hormones and tacrolimus belong to immune intervention, which is a single negative feedback mechanism, which can easily cause the skin’s defense system to become fragile, unsustainable, and have many side effects, such as hirsutism, skin atrophy, edema, interference Endocrine and pathogenic persistent infection, long-term or repeated
Moreover, hormones and other immunosuppressants have the effect of inhibiting cell regeneration and the generation of extracellular matrix, which will seriously interfere with the cell microenvironment and cell homeostasis, weaken the biological effect, and aggravate bacterial infection. Unsatisfactory or basically ineffective
In addition, there is a single factor that neutralizes and regulates inflammatory mediators, and the symptoms cannot be changed quickly due to the single biological pathway

Method used

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  • Repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and preparation method of repairing essence
  • Repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and preparation method of repairing essence
  • Repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and preparation method of repairing essence

Examples

Experimental program
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Effect test

Embodiment 1

[0042] This example provides a method for preparing a repairing essence based on adaptogens to regulate the stability of the epithelial immune microenvironment, including the following steps:

[0043] According to parts by mass, obtain 0.5 parts of β-glucan, 10 parts of yeast lysate, 10 parts of organic agave extract, 2 parts of tetrahydropyrimidine carboxylic acid, 5 parts of matsutake extract, and 5 parts of blue-green algae extract 3 parts, 3 parts of hydrolyzed royal jelly protein, 5 parts of humectant, 0.8 part of preservative; add water and titrate to 100 parts, and mix well to obtain the repairing essence.

Embodiment 2

[0045] This example provides a repairing essence based on adaptogens to regulate the stable epithelial immune microenvironment. The repairing essence is prepared by the preparation method provided in Example 1; it includes the following components in proportion by mass: β-glucan 0.5%, yeast lysate 10%, organic agave extract 10%, ectoine carboxylic acid 2%, matsutake extract 5%, blue-green algae extract 5%, hydrolyzed royal jelly protein 3%, humectant 5%, preservative 0.8%; the balance is water.

[0046] see figure 1 , NF-κB is an inflammatory transcription factor, and inhibiting the activity of NF-κB can block the inflammatory response pathway and inhibit the occurrence of inflammatory response. Many factors can cause the activation of NF-κB, such as allergens, ultraviolet radiation, free radicals, abnormal apoptosis cells, pathogen infection, and cytokines such as TNF-α and interleukin-1β subunits. Dilute the repairing essence provided in this example to 0.8 mg / L, 4.0 mg / L,...

Embodiment 3

[0053] This example provides a repairing essence based on adaptogens to regulate the stability of the epithelial immune microenvironment, which includes the following components by mass ratio:

[0054] Beta-glucan 0.2%, yeast lysate 5%, organic agave extract 5%, ectoine carboxylic acid 1%, matsutake extract 2%, blue-green algae extract 2%, hydrolyzed royal jelly protein 1%, gluconolactone 0.1%, sodium benzoate 0.05%, glycerin 1%, full-spectrum sodium hyaluronate 0.1%, inositol 0.5%, and the balance is water.

[0055] see Figure 4 , Subject 1 was suffering from acute skin allergies, using the repairing essence provided in this example, wet compressing 3 times a day, the effect of 10 days was compared with Figure 4 Shown; skin redness and itching have been significantly improved.

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Abstract

The invention provides a repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and a preparation method of the repairing essence, and the repairing essence comprises the following components in percentage by mass: 0.01-1% of beta-glucan, 1-20% of a saccharomycetes lysate, 1-20% of an organic maguey extract, 0.2-5% of ectoine, 0.3-10% of a tricholoma matsutake extract, 0.5-10% of blue-green algae extract, 0.5-5% of hydrolyzed royal jelly protein, 1.6-8.8% of humectant, 0.15-1.2% of preservative and the balance of water. The repairing essence provided by the invention is based on an immune regulation system of an organism, promotes proliferation of fibroblasts and production of extracellular matrixes, and inhibits expression of MMP-1 matrix metalloproteinase, so that immune self-stabilization and immune defense capabilities of skin are regulated, skin tissue immune internal and external environments are recovered to be relatively stable, and the rapid relieving and repairing of skin inflammatory symptoms are realized.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a repairing essence based on an adaptogen that regulates the stability of the epithelial immune microenvironment and a preparation method thereof. Background technique [0002] In the Western medical system, almost all skin inflammations are collectively referred to as eczema; A chronic, itchy inflammatory skin disorder with a certain genetic predisposition associated with skin hypersensitivity to the environment and autoimmune abnormalities. Eczema mainly causes a vicious cycle of damage to the skin barrier, such as: thin stratum corneum, increased water loss rate, easy dry skin, abnormal filaggrin or gene deletion, loose stratum corneum structure, increased permeability of the skin barrier, and synthesis of lamellar bodies Lipid imbalance, etc. Eczema is not limited to the manifestation of skin inflammation, but also an immune system disease driven by Th1 cells and Th2 cell...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/64A61K8/73A61K8/9728A61K8/9794A61K8/49A61Q19/00A61Q19/08
CPCA61K8/73A61K8/9728A61K8/9794A61K8/4953A61K8/99A61K8/64A61Q19/005A61Q19/00A61Q19/08A61Q19/004A61K2800/5922
Inventor 朱国君罗晓丹邢辉
Owner 浙江伊瑟奇医药科技有限公司
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