DNA nano machine, and application thereof in reducing blood sugar

Abstract

The invention provides a DNA nano machine. The DNA nano machine comprises a receptor and an actuator which are composed of nucleotide sequences, the receptor comprises a nucleotide chain R used for being combined with glucose molecules, and further comprises a nucleotide chain Hs and a closed chain Bs used for closing the Hs, the actuator comprises a nucleotide chain Ha and a closed chain Ba, the nucleotide chain Ha and the closed chain Ba are used for jointly acting with the Hs chain in the receptor to execute a certain function, the closed chain Ba is used for closing the Ha chain, and the Hs chain and the Ha chain can be subjected to partial chain segment base pairing, so that the Hs chain and the Ha chain can be combined to form a dimer structure, and the closed chain Bs chain and the closed chain Ba chain are correspondingly dissociated. The DNA nano machine responds to hyperglycemia in vivo and does not respond to low sugar, and has a hypoglycemic function only when the hyperglycemia in vivo exists, so that the risk of hypoglycemia in an insulin treatment process is avoided. The DNA nano machine has the advantages of intelligence, high efficiency, stability, low toxicity and the like.

Description

technical field [0001] The invention relates to the fields of biochemistry and medicine, in particular to a DNA nanometer machine and its application in lowering blood sugar. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, often leading to serious secondary complications, affecting 425 million people worldwide. Type 2 diabetes accounts for more than 90% of diabetic patients. Insulin resistance is one of the typical characteristics of type 2 diabetes, that is, the efficiency of insulin to promote glucose uptake and utilization is reduced due to various reasons. Insulin therapy is currently the main method of diabetes treatment, however, insulin therapy has certain defects and risks. First, insulin production has some batch-to-batch variability and is less stable, and second, diabetes treatment often involves daily monitoring of blood glucose levels and multiple subcutaneous injections or infusions to adjust all...

AI Technical Summary

Problems solved by technology

Type 2 diabetes accounts for more than 90% of diabetic patients. Insulin resistance is one of the typical characteristics of type 2 diabetes, that is, the efficiency of insulin to promote glucose uptake and utilization is reduced due to various reasons.

Insulin therapy is currently the main method of diabetes treatment, however, insulin therapy has certain defects and risks

First, insulin production has some batch-to-batch variability and is less stable, and second, diabetes treatment often involves daily monitoring of blood glucose levels and multiple subcutaneous injections or infusions to adjust allowable doses for safety and efficacy

Finally, current options for insulin therapy are still limited by the risk of hypoglycemia and poor glycemic control

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