DNA nano machine, and application thereof in reducing blood sugar

A technology of nanomachines and blood sugar, which is applied in the fields of biochemistry and medicine, can solve problems such as poor stability, batch-to-batch variation, and poor blood sugar control, and achieve good stability and avoid hypoglycemia.

Active Publication Date: 2021-07-02
HUNAN UNIV
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  • Claims
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Problems solved by technology

Type 2 diabetes accounts for more than 90% of diabetic patients. Insulin resistance is one of the typical characteristics of type 2 diabetes, that is, the efficiency of insulin to promote glucose uptake and utilization is reduced due to various reasons.
Insulin therapy is currently the main method of diabetes treatment, however, insulin therapy has certain defects and risks
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  • DNA nano machine, and application thereof in reducing blood sugar
  • DNA nano machine, and application thereof in reducing blood sugar
  • DNA nano machine, and application thereof in reducing blood sugar

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Embodiment Construction

[0036] In order to facilitate the understanding of the present invention, the following will describe the present invention more fully. And give the preferred embodiment of the present invention. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing the embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention.

[0038] figure 1 It is the structural diagram of the DNA nanomachine described in the present invention and the schematic diagra...

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Abstract

The invention provides a DNA nano machine. The DNA nano machine comprises a receptor and an actuator which are composed of nucleotide sequences, the receptor comprises a nucleotide chain R used for being combined with glucose molecules, and further comprises a nucleotide chain Hs and a closed chain Bs used for closing the Hs, the actuator comprises a nucleotide chain Ha and a closed chain Ba, the nucleotide chain Ha and the closed chain Ba are used for jointly acting with the Hs chain in the receptor to execute a certain function, the closed chain Ba is used for closing the Ha chain, and the Hs chain and the Ha chain can be subjected to partial chain segment base pairing, so that the Hs chain and the Ha chain can be combined to form a dimer structure, and the closed chain Bs chain and the closed chain Ba chain are correspondingly dissociated. The DNA nano machine responds to hyperglycemia in vivo and does not respond to low sugar, and has a hypoglycemic function only when the hyperglycemia in vivo exists, so that the risk of hypoglycemia in an insulin treatment process is avoided. The DNA nano machine has the advantages of intelligence, high efficiency, stability, low toxicity and the like.

Description

technical field [0001] The invention relates to the fields of biochemistry and medicine, in particular to a DNA nanometer machine and its application in lowering blood sugar. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, often leading to serious secondary complications, affecting 425 million people worldwide. Type 2 diabetes accounts for more than 90% of diabetic patients. Insulin resistance is one of the typical characteristics of type 2 diabetes, that is, the efficiency of insulin to promote glucose uptake and utilization is reduced due to various reasons. Insulin therapy is currently the main method of diabetes treatment, however, insulin therapy has certain defects and risks. First, insulin production has some batch-to-batch variability and is less stable, and second, diabetes treatment often involves daily monitoring of blood glucose levels and multiple subcutaneous injections or infusions to adjust all...

Claims

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Application Information

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IPC IPC(8): G01N33/66C12N15/11
CPCG01N33/66C12N15/11
Inventor 聂舟贺芳
Owner HUNAN UNIV
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