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Preparation method of bone repair material

A technology for bone repair and scaffold material, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc. It can solve the problems of limited application scope, insufficient strength and toughness, slow regeneration and reconstruction of bone tissue, etc. Effects of regeneration and reconstruction, increased strength, high toughness

Inactive Publication Date: 2021-06-22
WEIFANG AOJING MEDICAL RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial synthetic materials also have their shortcomings: 1) the strength and toughness are not enough, and the scope of application is limited; 2) the growth factors in artificial synthetic materials are lacking, and the regeneration and reconstruction of bone tissue are slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Step 1. Take fresh bovine bone, cut it into small pieces, degrease and remove antigen to obtain bovine bone granules. This step specifically includes: taking fresh bovine bone and dividing it into 10×10×10mm particles, washing it with warm water, soaking it in acetone solution for 12 hours, taking it out and soaking it in ether for 5 hours after the acetone volatilizes to realize degreasing. The hydrogen peroxide concentration of 8% was kept in hydrogen peroxide for 5 hours to achieve antigen removal.

[0016] Step 2. Soak the bovine bone particles in step 1 in the bone growth factor-collagen mixture, take it out and freeze-dry; the bone growth factor in this embodiment is insulin-like growth factor-1.

[0017] Step 3, taking the bovine bone particles in step 1, pulverizing and calcining to obtain bovine bone powder; the bovine bone powder is 100 mesh particles.

[0018] Step 4. Take the bovine bone particles in step 1, mix the bovine bone powder obtained in step 3 wit...

Embodiment 2

[0021] Step 1. Take fresh bovine bone, cut it into small pieces, degrease and remove antigen to obtain bovine bone granules. This step specifically includes: taking fresh bovine bone and dividing it into 10×10×10mm particles, washing it with warm water, soaking it in acetone solution for 12 hours, taking it out and soaking it in ether for 5 hours after the acetone volatilizes to realize degreasing. The hydrogen peroxide concentration of 9% was maintained in hydrogen peroxide for 5 hours to achieve antigen removal.

[0022] Step 2. Soak the bovine bone granules in step 1 in the bone growth factor-collagen mixture, take it out and freeze-dry; the bone growth factor in this embodiment is bone morphogenetic protein-2.

[0023] Step 3, taking the bovine bone particles in step 1, pulverizing and calcining to obtain bovine bone powder; the bovine bone powder is 120 mesh particles.

[0024] Step 4. Take the bovine bone particles in step 1, mix the bovine bone powder obtained in step ...

Embodiment 3

[0027] Step 1. Take fresh bovine bone, cut it into small pieces, degrease and remove antigen to obtain bovine bone granules. This step specifically includes: taking fresh bovine bone and dividing it into 10×10×10mm particles, washing it with warm water, soaking it in acetone solution for 12 hours, taking it out and soaking it in ether for 5 hours after the acetone volatilizes to realize degreasing. The hydrogen peroxide concentration was kept at 10% in hydrogen peroxide for 5 hours to achieve deantigenation.

[0028] Step 2. Soak the bovine bone particles in step 1 into the bone growth factor-collagen mixture, take it out and freeze-dry; the bone growth factor in this embodiment is fibroblast growth factor-2.

[0029] Step 3, taking the bovine bone particles in step 1, pulverizing and calcining, and pulverizing to obtain bovine bone powder; the bovine bone powder is 80 mesh particles.

[0030] Step 4. Take the bovine bone particles in step 1, mix the bovine bone powder obtain...

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PUM

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Abstract

The invention discloses a preparation method of a bone repair material. The preparation method comprises the following steps: step 1, taking a fresh bovine bone, cutting into small blocks, degreasing, and removing antigens to obtain bovine bone particles; step 2, soaking the bovine bone particles in the step 1 into a bone growth factor-collagen mixture, taking out the soaked bovine bone particles, and freeze-drying the soaked bovine bone particles; step 3, crushing and calcining the bovine bone particles in the step 1, and crushing to obtain bovine bone powder; step 4, mixing the bovine bone particles in the step 1 and the bovine bone powder obtained in the step 3 with collagen and nano-silver, and then putting the mixture into a forming mold for freeze-drying and forming to obtain a scaffold material; and step 5, carrying out crosslinking modification on the scaffold material obtained in the step 4. According to the bone repair material, the bovine bone particles serve as a skeleton of the bone repair material and play a role in enhancing strength, the mixture of the bovine bone powder and the collagen serves as filler, then cross-linking modification is conducted, high toughness is achieved, and bone growth factors can be slowly released in the bovine bone particles and play a role in promoting bone tissue regeneration and reconstruction; and the nano-silver in the filler has a sterilization effect.

Description

technical field [0001] The invention relates to the field of bone repair repair, in particular to a preparation method of a bone repair material. Background technique [0002] Bone injuries are often encountered in orthopedic treatment. There are many reasons for bone damage. Fractures caused by sports and accidents can cause bone damage. Bone damage may also occur during the treatment of bone tumors and bone diseases. When bone damage occurs, it is necessary to fill the bone tissue defect with bone repair material, which not only facilitates the fixation of the bone damage site, but also facilitates the re-growth of bone tissue. [0003] With the continuous development of the medical level, bone injury repair has gone through different stages such as the use of autologous bone repair materials, the use of allogeneic bone repair materials, the use of heterogeneous bone repair materials, and the use of artificial synthetic materials. [0004] Autologous bone repair material...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24A61L27/04A61L27/54A61L27/50
CPCA61L27/3608A61L27/365A61L27/3687A61L27/3691A61L27/24A61L27/047A61L27/54A61L27/50A61L2300/412A61L2430/02A61L2430/40A61L2300/414A61L2300/602A61L2400/12A61L2300/104A61L2300/404
Inventor 仇志烨刘洋李洪景崔孟龙宋天喜朱艳泽胡艳丽李良才朱金亮何志敏崔云
Owner WEIFANG AOJING MEDICAL RES CO LTD
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