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Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and preparation method thereof

The technology of chuanxiong extract and Chinese herbal medicine is applied in the field of Chinese herbal medicine bacteriostatic effervescent tablet and its preparation, which can solve the problem of limited bacteriostatic effect, and achieve the effect of promoting bacteriostatic effect, good inhibition effect, and reducing the spread of epidemic diseases

Pending Publication Date: 2021-06-22
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial effervescent tablets currently on the market have limited antibacterial effects and need to be further improved.

Method used

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  • Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and preparation method thereof
  • Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and preparation method thereof
  • Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Present embodiment effervescent tablet preparation method is as follows:

[0032] (1) Extraction of extract:

[0033] Take 15-30 parts by mass of Ligusticum Chuanxiong, 10-20 parts by mass of Gardenia, 5-15 parts by mass of Toosendan and 5-15 parts by mass of Myrobalan, mix them, powder them, soak them overnight in ethanol with a mass concentration of 70%, and then extract them with ultrasound After 60 min, it was filtered and concentrated under reduced pressure to obtain the extract. In this embodiment, the mass of one portion is 50 grams to 150 grams.

[0034] (2) Screening of auxiliary materials:

[0035] The auxiliary materials include acid source, alkali source, lubricant, diluent and flavoring agent. In this example, tartaric acid is used as the acid source, sodium bicarbonate is used as the alkali source, lactose is used as the diluent, PEG 6000 is used as the lubricant, and PEG 6000 is used as the flavoring agent. Tea polyphenols. All auxiliary materials are...

Embodiment 2

[0044] The present embodiment is used for measuring the bacteriostasis and the antibacterial synergistic effect of the effervescent tablet obtained in Example 1.

[0045] (1) Strain activation:

[0046] Under sterile conditions, use the freshly prepared bacterial solid slant medium to transfer the preserved strains of Escherichia coli, Staphylococcus aureus and Bacillus subtilis, culture at 37°C for 24 hours, and set aside; use the fungal solid slant medium to transfer Inoculate the preserved strains of Penicillium and Aspergillus niger, culture at 28°C for 72 hours, and set aside.

[0047] (2) Preparation of bacterial suspension:

[0048] Add sterile water to the activated inclined test tube of the test bacteria, pour it into 50mL sterile saline with glass beads, wrap it up, put it on a shaker and shake it at 37°C for 30min. By blood count method, the number of bacterial cells made of sterile water is 10 6 CFU / mL bacterial suspension, stored in a refrigerator at 4°C.

[0...

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PUM

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Abstract

The invention discloses a Chinese herbal medicine bacteriostatic effervescent tablet containing ligusticum wallichii extract and a preparation method thereof. The effervescent tablet mainly comprises active ingredients and auxiliary materials, the active ingredients comprise 15-30 parts by mass of ligusticum wallichii, 10-20 parts by mass of fructus gardeniae, 5-15 parts by mass of szechwan chinaberry fruit and 5-15 parts by mass of fructus. The auxiliary materials comprise an acid source, an alkali source, a lubricant, lactose and tea polyphenol. The effervescent tablet disclosed by the invention has a good inhibition effect on common bacteria which are easily contacted by daily exposure of skin. The product is convenient to carry and easy to store, and exposed skin parts such as hands and the like can be soaked and cleaned at any time after the hand-washing liquid is soaked in water, so that the cleaning and antibacterial effects are achieved. Many seasonal influenza viruses are transmitted through a hand-mouth way, and the purpose of reducing epidemic disease transmission can be achieved by using the effervescent tablets disclosed by the invention.

Description

technical field [0001] The invention belongs to extract preparations of traditional Chinese medicines, in particular to Chinese herbal antibacterial effervescent tablets containing chuanxiong extracts and a preparation method thereof. Background technique [0002] Antibacterial effervescent tablets need to be dissolved in water before external use, and have certain antibacterial properties. Compared with other antibacterial agents, effervescent tablets are easy to use and easy to store, so they are very popular. However, the antibacterial effervescent tablets currently on the market have limited antibacterial effects and need to be further improved. Contents of the invention [0003] The purpose of the present invention is to provide Chinese herbal antibacterial effervescent tablet containing Chuanxiong extract and preparation method thereof, the Chinese herbal antibacterial effervescent tablet has a good inhibitory effect on common bacteria that are easily exposed to ski...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/744A61P17/00A61P31/02A61P31/04A61P31/16
CPCA61K9/2068A61K9/0007A61K9/0014A61K36/236A61K36/744A61K36/58A61K36/185A61P17/00A61P31/02A61P31/04A61P31/16A61K2236/33A61K2236/51A61K2300/00
Inventor 雨田安玲艳杨勇李维郭晓恒邹亮
Owner CHENGDU UNIV
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