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Anti-swelling composite hydrogel, and preparation method and application thereof

A composite hydrogel and hydrogel technology, applied in the field of hydrogel, can solve the problems of compressing surrounding biological tissues and decreasing mechanical properties

Active Publication Date: 2021-06-11
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, when polymer hydrogels are used in living organisms, they often cause adverse reactions such as mechanical property degradation and compression of surrounding biological tissues due to high swelling rates.

Method used

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  • Anti-swelling composite hydrogel, and preparation method and application thereof
  • Anti-swelling composite hydrogel, and preparation method and application thereof
  • Anti-swelling composite hydrogel, and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0078] The invention provides a kind of preparation method of composite hydrogel, comprises the following steps:

[0079] 1) After mixing the hydrogel precursor, the auxiliary agent and the solvent, a hydrogel precursor solution is obtained;

[0080] The polymer material solution is formed into a matrix frame, and then a porous polymer material frame is obtained after pore making;

[0081] 2) Immerse the porous polymer material frame obtained in the above steps into the hydrogel precursor solution, and obtain a composite hydrogel after polymerization or crosslinking.

[0082] The selection, ratio and parameters of raw materials or products in the above-mentioned preparation method of the present invention, as well as the corresponding optimization principles, etc., if not specified, are the same as the selection of raw materials, ratios and parameters in the aforementioned composite hydrogel, and the corresponding optimization principles They all correspond to each other, and...

Embodiment 1

[0111]The chitosan aqueous solution with a concentration of 2wt.% is cross-linked by genipin, and then 0.25wt.% sodium hydroxide ethanol solution is used to remove acid, then deionized water is used for neutralization, and then ethanol is used to replace the water in the framework. Then use supercritical drying to make a drying frame.

[0112] Dissolve acrylamide monomer, initiator ammonium persulfate, and cross-linking agent methylenebisacrylamide in deionized water to make a polyacrylamide hydrogel precursor solution. After infiltrating and drying the frame for 24 hours, thermally initiate cross-linking , prepared into chitosan / polyacrylamide hydrogel composite matrix.

[0113] Wherein the concentrations of the acrylamide monomer, the initiator ammonium persulfate, and the crosslinking agent methylenebisacrylamide are 5%, 0.1%, and 0.01%, respectively.

[0114] Under the same conditions, a separate polyacrylamide hydrogel was prepared.

[0115] The chitosan / polyacrylamide ...

Embodiment 2

[0125] The polylactic acid tetrahydrofuran solution with a concentration of 2wt.% was allowed to form a gel at -18°C, the tetrahydrofuran was replaced with distilled water, frozen at -80°C, and then placed in a vacuum freeze dryer to freeze-dry to form a frame.

[0126] Dissolve N-isopropylacrylamide, initiator ammonium persulfate, cross-linking agent methylenebisacrylamide and photoinitiator 1173 in deionized water to prepare poly(N-isopropylacrylamide) hydrogel After soaking the dry frame for 24 hours, 360nm ultraviolet light triggers cross-linking, and prepares polylactic acid / poly(N-isopropylacrylamide) hydrogel composite matrix.

[0127] The contents of N-isopropylacrylamide, crosslinking agent methylenebisacrylamide and photoinitiator 1173 are 5%, 0.01% and 0.5% respectively.

[0128] Under the same conditions, a separate poly(N-isopropylacrylamide) hydrogel was prepared.

[0129] The polylactic acid / poly(N-isopropylacrylamide) hydrogel composite matrix and poly(N-isopr...

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Abstract

The invention provides a composite hydrogel. The composite hydrogel comprises a porous high polymer material framework and hydrogel compounded in the porous high polymer material framework. The composite hydrogel contains the porous polymer material framework, the polymer material framework is used as an insoluble mechanical binding skeleton, long-chain hydrogel is used as a high-water-content functional module, and the hydrogel is immersed in porous holes of the polymer skeleton framework. The composite hydrogel prepared in the invention has relatively strong functionality and excellent swelling resistance, and the preparation method is simple and suitable for large-scale popularization and application.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and relates to a composite hydrogel and its preparation method and application, in particular to an anti-swelling composite hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a kind of extremely hydrophilic three-dimensional network structure gel, which swells rapidly in water and can maintain a large volume of water without dissolving in this swollen state. Due to the presence of cross-linked networks, hydrogels can swell and retain a large amount of water, and the amount of water absorbed is closely related to the degree of cross-linking. The higher the degree of crosslinking, the lower the water absorption. This property is much like a soft tissue. The water content in hydrogels can be as low as a few percent or as high as 99%. The aggregate state of the gel is neither a complete solid nor a complete liquid. All water-soluble or hydrophilic pol...

Claims

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Application Information

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IPC IPC(8): C08J9/40C08L5/08C08L67/04C08L5/12
CPCC08J9/405C08J2305/08C08J2367/04C08J2305/12
Inventor 俞书宏潘钊邹多宏吴靖
Owner UNIV OF SCI & TECH OF CHINA
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