Targeted drug loading system based on black phosphorus nanosheets and preparation method of targeted drug loading system

Abstract

The invention provides a preparation method of a targeted drug loading system based on black phosphorus nanosheets, which comprises the following steps: obtaining BPNSs through a liquid phase stripping method, and modifying the BPNSs through PAMAM to obtain a nano sustained-release drug loading system capable of loading drugs. The black phosphorus nanosheet is adopted, and due to the excellent optical property of the black phosphorus nanosheet, the nano-carrier has the photoacoustic imaging function; secondly, PAMAM is used for modification, so that the biocompatibility of the black phosphorus nanosheet is improved; and the Angiopep-2 polypeptide promotes the enrichment of the nano material in tumor cells. The nano material improves the treatment effect on the brain metastasis of the lung cancer, and provides a new idea for efficient diagnosis and treatment integration of the brain metastasis of the lung cancer.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and in particular relates to a targeted drug loading system based on black phosphorus nanosheets and a preparation method thereof. Background technique [0002] At present, the incidence of lung cancer ranks first among malignant tumors in China, and its brain metastasis is the main cause of death of cancer patients. At present, most of the treatment methods for brain metastases of lung cancer are traditional surgery, radiotherapy, chemotherapy and so on. Surgery and radiotherapy are local treatments, which are only effective on the tumor at the treatment site, and are difficult to play a role on the tumor that has migrated. Chemotherapy drugs are mostly non-targeted, killing normal tissue cells while killing cancer cells, resulting in obvious toxic reactions in some normal tissues and organs of the body. In addition, long-term drug treatment will also produce drug resistance and...

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Problems solved by technology

[0005] However, due to the hydrophobicity and poor water solubility of most chemotherapy drugs, and the imperfect delivery system and poor stability of small molecule inhibitors, especially polypeptide molecule inhibitors, they are easily cleared in the blood after administration, and the half-life of drugs Very short, low bioavailability, resulting in limited application of chemotherapy drugs and peptide inhibitors

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