Identification of specific immune cell subtypes in new coronavirus infected peripheral blood and application of specific immune cell subtypes in new coronavirus infected peripheral blood

A coronavirus, cell technology, applied in blood/immune system cells, animal cells, antiviral agents, etc., can solve the problems of lack of specific methods, inability to meet the needs of diagnosis and prediction, lack of cell analysis, etc., to strengthen the clearance and inhibition, strong immune killing effect

Pending Publication Date: 2021-06-01
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

At present, the disease classification and prognosis of COVID-19 patients are mainly based on clinical symptoms (fever, cough and other respiratory symptoms, respiratory rate, oxygen saturation rate, oxygenation index, etc.) Counting, detection of cell inflammatory factor content, etc.), it has a certain lag in disease progression and prognosis analysis and lacks a specific method for the diagnosis of COVID-19. For patients with rapid progression and multiple disease foundations, it cannot meet the current diagnosis and prognosis. Judgment needs...

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  • Identification of specific immune cell subtypes in new coronavirus infected peripheral blood and application of specific immune cell subtypes in new coronavirus infected peripheral blood
  • Identification of specific immune cell subtypes in new coronavirus infected peripheral blood and application of specific immune cell subtypes in new coronavirus infected peripheral blood
  • Identification of specific immune cell subtypes in new coronavirus infected peripheral blood and application of specific immune cell subtypes in new coronavirus infected peripheral blood

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Embodiment Construction

[0106] The following specific embodiments disclose many technical details, however, it should not be construed as limiting the protection scope of the present invention.

[0107] 1. Specific implementation methods

[0108] 1.1 Sample Queue

[0109] Collect 42 peripheral blood samples from 39 COVID-19 patients and 11 healthy people, and extract peripheral blood mononuclear lymphocytes (Table 1). The diagnosis and classification of the included patients are based on the World Health Organization interim guidelines And the implementation of the new crown pneumonia diagnosis and treatment plan issued by the People's Republic of China. According to clinical symptoms, COVID-19 patients were divided into asymptomatic infection (AS, n=5), symptomatic infection (SM, n=34), and symptomatic infection was divided into mild / common type (MD, n =13), severe / critical (SD, n=10), severe / critical recovery period (SDR, n=11). At the same time, symptomatic patients can be divided into patients...

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Abstract

The invention relates to identification of specific immune cell subtypes in new coronavirus infected peripheral blood and application of the specific immune cell subtypes, and provides immune cell populations and subpopulations which play an important role in occurrence and development of COVID-19 diseases. The first class can be used for T cell immunotherapy, DC cell immunotherapy and B cell immunotherapy of new coronal pneumonia and immunotherapy of old patients; the second class can be used for screening and designing a medicine for inhibiting cytokine storm and a medicine for inhibiting T cell reduction; the third class can be used for diagnosis of new coronal pneumonia.

Description

technical field [0001] The invention belongs to the field of diagnosis of novel coronavirus pneumonia, and in particular relates to the identification and application of specific immune cell subtypes in peripheral blood infected with novel coronavirus. Background technique [0002] Diagnosis of infection with the new coronavirus (SARS-CoV-2) can include diagnosis of pneumonia using computed tomography (CT) and detection of virus in throat swab samples, lower respiratory tract secretions, peripheral blood, or stool by real-time RT-PCR RNA (extracted with SARS-CoV-2 specific primers and probes). According to clinical manifestations, COVID-19 is divided into four types, namely mild, common, severe and critical. Some patients without clinical manifestations but nucleic acid tests are considered asymptomatic patients. Due to the lack of specific drugs against the virus SARS-CoV-2, current clinical treatment of this disease mainly relies on supportive care to reduce inflammation ...

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Application Information

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IPC IPC(8): A61K35/17A61K35/15A61P31/14A61P11/00C12N5/0781C12N5/0783C12N5/0784C12Q1/02
CPCA61K35/15A61K35/17A61P11/00A61P31/14C12N5/0635C12N5/0636C12N5/0639G01N33/5005G01N2800/26G16H50/20G16H50/80A61K2300/00
Inventor 施秉银张呈生王晓蕊白晗马俊鹏秦红玉曾琪琦胡方齐昕李梦阳
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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