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Nanorod array textured coating with anti-oxidation and self-generating oxygen functions on titanium-based surface, its preparation method and application

A technology of nanorod array and chemical coating, which is applied in the direction of surface reaction electrolytic coating, coating, anodic oxidation, etc., to achieve the effect of strong repeatability, simple composition and stable process

Active Publication Date: 2021-12-28
陕西佳诺博奥生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at fractures in RA conditions, in order to solve the problems existing in the surface modification of titanium-based implants, the purpose of the present invention is to provide a nanorod array textured coating and Its preparation method and application have stable process and strong controllability; the surface layer of the prepared biomedical material has dual functions of anti-oxidation and self-generating oxygen; and as an implant, it can regulate ROS and hypoxic bone under the condition of RA. Promote the healing and regeneration of bone tissue in time after the microenvironment, and avoid the peeling of the coating induced by the poor membrane / substrate binding force and the occurrence of side reactions such as osteolysis or excessive inflammation induced by it

Method used

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  • Nanorod array textured coating with anti-oxidation and self-generating oxygen functions on titanium-based surface, its preparation method and application
  • Nanorod array textured coating with anti-oxidation and self-generating oxygen functions on titanium-based surface, its preparation method and application
  • Nanorod array textured coating with anti-oxidation and self-generating oxygen functions on titanium-based surface, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A method of preparing a biomedical material having a nanorod array of thermists and antioxidant coatings, including the surface of the titanium-based surface, including the following steps:

[0041] Step 1, the micro-arc oxidation of titanium and its alloy:

[0042] The micro-array is set to: the micro-alignment arc frequency is 110 Hz, the power supply is 400 V, and the duty ratio is 7.5%. During the micro-arc oxidation, pure titanium or titanium alloy as an anode, the stainless steel electrolytic cell is the cathode, the electrolyte ingredients and concentrations are: sodium hydroxide (NaOH) 0.005 mol / L, calcium acetate (CA (CA) 3 COO) 2 0.2 mol / L, β-phosphate sodium salt five hydrothermal compound (β-GP) 0.02 mol / L. The temperature of the micro-arc oxidation electrolyte is controlled during the preparation process is 300K. After the micro-arc is oxidized, a sample coated with a microporous titanium dioxide is obtained, and the prepared sample is placed in a dry cas...

Embodiment 2

[0053] A method of preparing a biomedical material having a nanorod array of thermists and antioxidant coatings, including the surface of the titanium-based surface, including the following steps:

[0054] Step 1, the micro-arc oxidation of titanium and its alloy:

[0055] The micro-array is set to: the micro-alignment arc frequency is 110 Hz, the power supply is 400 V, and the duty ratio is 7.5%. During the micro-arc oxidation, pure titanium or titanium alloy as an anode, the stainless steel electrolytic cell is the cathode, the electrolyte ingredients and concentrations are: sodium hydroxide (NaOH) 0.005 mol / L, calcium acetate (CA (CA) 3 COO) 2 0.2 mol / L, β-phosphate sodium salt five hydrothermal compound (β-GP) 0.02 mol / L. The temperature of the micro-arc oxidation electrolyte is controlled during the preparation process is 300K. After the micro-arc is oxidized, a sample coated with a microporous titanium dioxide is obtained, and the prepared sample is placed in a dry cas...

Embodiment 3

[0066] A method of preparing a biomedical material having a nanorod array of thermists and antioxidant coatings, including the surface of the titanium-based surface, including the following steps:

[0067] Step 1, the micro-arc oxidation of titanium and its alloy:

[0068] The micro-array is set to: the micro-alignment arc frequency is 110 Hz, the power supply is 400 V, and the duty ratio is 7.5%. During the micro-arc oxidation, pure titanium or titanium alloy as an anode, the stainless steel electrolytic cell is the cathode, the electrolyte ingredients and concentrations are: sodium hydroxide (NaOH) 0.005 mol / L, calcium acetate (CA (CA) 3 COO) 2 0.2 mol / L, β-phosphate sodium salt five hydrothermal compound (β-GP) 0.02 mol / L. The temperature of the micro-arc oxidation electrolyte is controlled during the preparation process is 300K. After the micro-arc is oxidized, a sample coated with a microporous titanium dioxide is obtained, and the prepared sample is placed in a dry cas...

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Abstract

The invention discloses a nano-rod array structured coating with a titanium-based surface having both anti-oxidation and self-generating oxygen functions, a preparation method and an application thereof. Firstly, a porous titanium dioxide coating containing phosphorus and calcium was prepared on the surface of titanium or its alloys by micro-arc oxidation, and then a hydroxyapatite nanorod textured coating was grown in situ by hydrothermal treatment, and then polymer was prepared by oxidative self-polymerization. The dopamine-coated hydroxyapatite nanorod array is finally obtained by polydopamine adsorption of metal ions and hydrothermal method to obtain a biomedical material with both anti-oxidation and self-generating oxygen coating. The process of the invention is stable and controllable; the prepared coating surface has dual functions of anti-oxidation and self-generating oxygen at the same time; as an implant, it can regulate the bad bone microenvironment under the condition of RA, promote the healing and regeneration of bone tissue, Avoid the failure of the implant due to the poor bone microenvironment, the peeling of the coating induced by the poor membrane / base binding force, and the side effects such as osteolysis or excessive inflammation induced by it.

Description

Technical field [0001] The present invention belongs to the field of biotechnology medical materials, in particular to a surface of a titanium-based antioxidant both oxygen and autogenous function nanorod array configuration coatings and preparation method and application. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, the pathogenesis of the joint area within, synovial fluid mostly macrophage proinflammatory phenotype M1 to the region of reactive oxygen free radicals (ROS ) and expression of inflammatory factors increased significantly and transported with the blood circulation to the body; serum ROS expression of inflammatory factors and will induce bone hypoxia by activating NF-κb pathway promotes osteoclast differentiation and maturation, resulting in RA patients with systemic bone loss, increased risk of fractures. More concerned, once fracture RA patients, the serum ROS content and a high hypoxic microenvironment within the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/32A61L27/34A61L27/56C25D11/02C25D11/26
CPCA61L27/06A61L27/306A61L27/32A61L27/34A61L27/56C25D11/026C25D11/26A61L2420/08C08L79/04
Inventor 李博刘福立憨勇
Owner 陕西佳诺博奥生物科技有限公司
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