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Bone repair material, preparation method thereof and cranio-maxillofacial repair prosthesis

A repair material and craniofacial technology, applied in the field of bone repair, can solve problems such as unbalanced nutrient supply, difficulty in interstitial fluid interaction, easy atrophy and exposure of soft tissue without attachment points, and achieve the effect of accelerating rapid fusion

Active Publication Date: 2021-05-11
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of existing bone repair materials, such as difficulty in interaction of interstitial fluid after bone repair surgery, unbalanced nutrient supply, easy atrophy and exposure of soft tissue without attachment points, and provide a method that increases interstitial fluid interaction and speeds up the interaction between repair materials and Rapid soft tissue fusion, bone repair material with soft tissue repair function

Method used

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  • Bone repair material, preparation method thereof and cranio-maxillofacial repair prosthesis
  • Bone repair material, preparation method thereof and cranio-maxillofacial repair prosthesis
  • Bone repair material, preparation method thereof and cranio-maxillofacial repair prosthesis

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Effect test

Embodiment 1

[0045] Embodiment 1 A kind of bone repair material

[0046] The bone repair material is composed of a main part and a hydrophilic sponge part, the main part is connected with the hydrophilic sponge part through hydrogen bonds after being hydrophilically modified, the main part has a through-hole structure, and the hydrophilic sponge part filling in the through hole of the body part and covering the surface of the body part;

[0047] Wherein, the main part is polyether ether ketone, and the surface contact angle after hydrophilic modification is 60°; the hydrophilic sponge part is hyaluronic acid; the porosity of the through-hole structure of the main part is 30% , the cross-sectional area of ​​a single through hole is 15mm 2 ; The thickness of the main body part is 2.0 mm, and the thickness of the hydrophilic sponge part covering the surface of the main body part is 0.1 mm.

[0048] The preparation method comprises the following steps:

[0049] S1. The main part with a thro...

Embodiment 2

[0056] Embodiment 2 A kind of bone repair material

[0057] The bone repair material is composed of a main part and a hydrophilic sponge part, the main part is connected with the hydrophilic sponge part through hydrogen bonds after being hydrophilically modified, the main part has a through-hole structure, and the hydrophilic sponge part filling in the through hole of the body part and covering the surface of the body part;

[0058] Wherein, the main part is polyether ketone ketone, and the surface contact angle after hydrophilic modification is 30°; the hydrophilic sponge part is gelatin; the porosity of the through-hole structure of the main part is 10%. The cross-sectional area of ​​the through hole is 5mm 2 ; The thickness of the main body part is 2.0 mm, and the thickness of the hydrophilic sponge part covering the surface of the main body part is 0.2 mm.

[0059] The preparation method comprises the following steps:

[0060] S1. The main part with a through-hole struc...

Embodiment 3

[0068] Embodiment 3 A kind of bone repair material

[0069] The bone repair material is composed of a main part and a hydrophilic sponge part, the main part is connected with the hydrophilic sponge part through hydrogen bonds after being hydrophilically modified, the main part has a through-hole structure, and the hydrophilic sponge part filling in the through hole of the body part and covering the surface of the body part;

[0070] Wherein, the main part is polyether ether ketone ketone, and the surface contact angle after hydrophilic modification is 44°; the hydrophilic sponge part is gelatin and hyaluronic acid; the through-pore structure porosity of the main part is is 50%, and the cross-sectional area of ​​a single through hole is 1mm 2 ; The thickness of the main body part is 1.0 mm, and the thickness of the hydrophilic sponge part covering the surface of the main body part is 0.05 mm.

[0071] The preparation method comprises the following steps:

[0072] S1. The mai...

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Abstract

The invention belongs to the technical field of bone repair, and particularly relates to a bone repair material, a preparation method thereof and a cranio-maxillofacial repair prosthesis. The material comprises a main body part and a hydrophilic sponge part, wherein the main body part is connected with the hydrophilic sponge part through a hydrogen bond after hydrophilic modification, the main body part is provided with a through hole structure, and the hydrophilic sponge part fills the through hole of the main body part and covers the surface of the main body part. The bone repair material can increase interaction of tissue fluid on two sides of the material, provides an attachment point for soft tissue, and accelerates fusion of the repair material and the soft tissue, thereby achieving a remarkable repair effect and being very suitable for cranio-maxillofacial bone defect repair, especially cranio-maxillofacial bone defect repair of parts with more soft tissue.

Description

technical field [0001] The invention belongs to the technical field of bone repair. More specifically, it relates to a bone repair material, a preparation method thereof and a craniomaxillofacial repair prosthesis. Background technique [0002] Craniomaxillofacial bone is one of the most important parts of human bones. Unfortunately, if a skull injury occurs, it will not only affect the patient's appearance and bring insecurity to the patient, but more seriously, it may lead to re-damage of the brain tissue. In order to prevent re-injury of the brain tissue, restore the airtightness of the cranial cavity, and not affect the appearance of the patient, surgery is usually used to repair craniofacial bone defects. [0003] At present, for the repair of bone defects, the repair materials mainly include autologous bone, allogeneic bone, medical polymer materials, titanium metal materials, bone cement, etc. For example, Chinese patent application CN108175539A discloses a bone pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/50A61L27/56
CPCA61L27/18A61L27/20A61L27/222A61L27/50A61L27/56A61L2430/02A61L2300/412A61L2430/34C08L61/16C08L5/08
Inventor 马骋邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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