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Method for identifying triptolide in kunxian capsules and measuring content of triptolide

A technology of triptolide and its determination method, which is applied in the field of drug detection, can solve problems such as low content, complex pretreatment methods, and poor specificity of reproducible detection components, achieving high accuracy and reproducibility, and ensuring safety Effect

Pending Publication Date: 2021-04-30
SHANGHAI CHANGZHENG HOSPITAL
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Problems solved by technology

[0005] The object of the present invention is to provide a method for qualitative and quantitative analysis of triptolide in Kunxian Capsules by thin-layer chromatography and high-performance liquid chromatography, which has solved the complicated pretreatment method and low content in the prior art. Problems that need to be improved urgently, such as poor reproducibility and specificity of detection components

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  • Method for identifying triptolide in kunxian capsules and measuring content of triptolide
  • Method for identifying triptolide in kunxian capsules and measuring content of triptolide
  • Method for identifying triptolide in kunxian capsules and measuring content of triptolide

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Embodiment

[0026] 1. Experimental materials

[0027] 1.1. Experimental Instruments

[0028] Agilent1260 high performance liquid chromatography (including infusion pump, automatic sampler, column thermostat, diode array detector): American Agilent Technology Co., Ltd.; one hundred thousandth analytical balance: German Sartorius company; ultrasonic machine: KQ-500 Type, Kunshan Ultrasonic Instrument Co., Ltd.

[0029] 1.2. Experimental reagents and medicines

[0030] Acetonitrile, methanol, and formic acid are all chromatographically pure: Fisher Scientific Company of the United States, water is Hangzhou Wahaha purified water, and other reagents are analytically pure; triptolide reference substance: provided by Dalian Meilun Biological Co., Ltd.;

[0031] Kunming mountain crabapple reference medicinal materials: China National Institutes for Food and Drug Control; 21 batches of Kunxian capsule samples were provided by Guangzhou Baiyunshan Chenliji Pharmaceutical Co., Ltd., and the produc...

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Abstract

The invention relates to the technical field of medicine detection, in particular to a method for identifying triptolide in kunxian capsules and measuring the content of triptolide. The invention establishes a technology for qualitatively and quantitatively analyzing triptolide in kunxian capsules by adopting thin-layer chromatography and high-performance liquid chromatography, solves the problems of difficulty in determination of triptolide, poor repeatability and the like in the original standard, has strong specificity, accuracy and reproducibility, can more objectively and sensitively reflect the quality change of the product. Therefore, toxic components in the preparation can be effectively monitored, and the medication safety and effectiveness of patients are further ensured.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for qualitatively and quantitatively analyzing triptolide in Kunxian capsules by thin layer chromatography and high performance liquid chromatography. Background technique [0002] Kunxian Capsules (KC) is a six-category new drug of traditional Chinese medicine transformed from the achievements of the national "Ninth Five-Year Plan" project. Rheumatoid arthritis belongs to the syndrome of rheumatic numbness combined with kidney deficiency (Harris E D Jr, Budd R C, Firestein G S, et al. Kelly Rheumatology [M]. 7th Edition, Beijing: People's Health Publishing House, 2006). Among them, Kunming Begonia is the monarch drug, which has the effects of expelling wind and dampness, promoting blood circulation and stopping bleeding; Epimedium is the subject drug, which has the effects of nourishing the gate of life, benefiting essence, strengthening muscles and bones, tonify...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74G01N30/90
CPCG01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74G01N30/90G01N2030/324
Inventor 许春芳陶霞杨宏高守红张凤傅志勤
Owner SHANGHAI CHANGZHENG HOSPITAL
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