Absorbable hydrogel skin repair scaffold constructed on the basis of recombinant human collagen, preparation method and use method thereof

Abstract

The invention relates to an absorbable hydrogel skin repair scaffold constructed on the basis of recombinant human collagen, a preparation method and a use method thereof. The main structural component of the scaffold is human collagen, and the scaffold has excellent water absorption, water retention and air permeability and can provide a wet repair environment for a wound surface. When the skin is wounded, the hydrogel is smeared on the wound surface, the outer layer is covered with the medical wound dressing, and the wound surface hydrogel is physically isolated from the outside. The hydrogel not only maintains extracellular moisture, but also directly provides skin with a material which is homologous with human collagen finally generated by cell repair, and directly participates in a skin dermis extracellular matrix remodeling process, so that scars are reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular, the invention relates to a recombined human collagen absorbable hydrogel skin support and a preparation method and a use method thereof. Background technique [0002] With the development of life, production, transportation, as well as radiotherapy and chemotherapy, chronic diseases, and population aging, the skin, as the outermost physical defense barrier of the human body, is the first to suffer damage, and skin wounds often eventually heal in the form of scars. When the skin is physically damaged, the homeostasis of the skin is temporarily stopped, and it turns to wound healing and repair reactions. Full-thickness skin wounds often lead to scar formation, and the hyperplasia, sclerosis, and contracture of the scar will lead to the loss of function and deformity of the appearance of the patient. Affects the labor force and creates a burden on the family. [0003] Commerc...

AI Technical Summary

Problems solved by technology

Although skin energy fast healing dressing (PELNAC) and double-layer artificial dermal repair material (Lando) have good therapeutic effects on deep burn wounds, traumatic skin loss, and chronic refractory wounds, but due to their main clinical The source of raw materials for the therapeutic effect is collagen extracted from animals, and there is a risk of transmission of animal xenogeneic animal viruses. Animal-derived protein materials may have shortcomings and deficiencies such as heterogeneous immune rejection and allergic reactions to the human body. ), double-layer artificial dermis repair material (Lando) requires suture and secondary surgery during treatment, and it also has its limitations for complex wounds (such as deep and shallow wounds, sinus wounds)

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