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Multivitamin calcium self-emulsifying composition and preparation method of preparation thereof

A self-emulsifying and composition technology, applied in the fields of drug combination, anhydride/acid/halide active ingredients, food science, etc., can solve the problems of slow absorption, low bioavailability, etc., to promote absorption, increase miscibility, improve The effect of bioavailability

Inactive Publication Date: 2021-04-30
湖北真奥医药研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a multi-dimensional calcium self-emulsifying composition and a preparation method thereof to solve the problems of slow absorption and low bioavailability of oral calcium supplements and vitamin supplements currently available on the market

Method used

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  • Multivitamin calcium self-emulsifying composition and preparation method of preparation thereof
  • Multivitamin calcium self-emulsifying composition and preparation method of preparation thereof
  • Multivitamin calcium self-emulsifying composition and preparation method of preparation thereof

Examples

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Effect test

Embodiment 1

[0032] In the multidimensional calcium self-emulsifying composition, the weight ratio of each component in the prescription is:

[0033]

[0034] Preparation method: mix the raw materials in the formula of calcium preparation evenly, add appropriate amount of water to make soft material, pass through a 14-mesh sieve to prepare granules, dry at 40-60°C for 2 hours, and granulate to obtain the calcium composition. Weigh an appropriate amount of each raw material, add the mixed emulsifier, co-emulsifier, and ethyl oleate in the prescribed amount, and mix well at 37-40°C to obtain a uniform vitamin D3, vitamin K2, and vitamin A self-microemulsion concentrate. According to the ratio of 0.4g self-microemulsion concentrate absorbed by 1g mannitol, appropriate amount of mannitol was weighed, the self-microemulsion concentrate was added to the mannitol, and stirred evenly while adding. Add a small amount of water to make soft materials, pass through a 14-mesh sieve to prepare granul...

Embodiment 2

[0036] In the multidimensional calcium self-emulsifier composition, the weight ratio of each component in its prescription is:

[0037]

[0038]

[0039] Add water and mix well, granulate with 14 mesh, dry at 50°C, and granulate with 20 mesh. Take 2.6g of granules and put them in a beaker, add 15mL of water under magnetic stirring, the self-emulsification dissolves completely, and blue opalescence can be observed.

Embodiment 3

[0041] In the multidimensional calcium self-emulsifier composition, the weight ratio of each component in its prescription is:

[0042]

[0043] 30% ethanol, 95% ethanol, and absolute ethanol were mixed with self-emulsifying preparations as wetting agents for granulation. Granulate with 14 mesh, dry at 50°C, and granulate with 20 mesh. The particles made of absolute ethanol can be self-emulsified and dissolved by adding water under magnetic stirring at 37°C.

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Abstract

The invention discloses a multivitamin and calcium self-emulsifying composition and a preparation method of a preparation of the multivitamin and calcium self-emulsifying composition. The composition of the present invention comprises an effective amount of calcium, vitamins, an oil phase, an emulsifier, and a co-emulsifier, and the composition is in the form of a solid. According to the composition, the vitamin is a fat-soluble vitamin, and the calcium agent is a water-soluble calcium agent. The composition disclosed by the invention can spontaneously generate a self-emulsifying effect when meeting water in vitro and vivo to form highly uniformly dispersed self-emulsifying liquid, so that the solubility and bioavailability of the self-emulsifying liquid can be improved, and the absorption of calcium and vitamins is promoted. The three-dimensional calcium self-emulsifying agent particle composition disclosed by the invention is used for daily food additives, vitamins and calcium supplements, or used for treatment medicines with obvious calcium deficiency and vitamin deficiency signs. The composition has the advantages of being convenient to take, stable in storage, high in bioavailability, capable of supplementing calcium and vitamins, rapid in absorption and the like.

Description

technical field [0001] The invention relates to the field of calcium-supplementing vitamin-supplementing nutritious food, health food or medicine. More specifically, the present invention relates to a preparation method of a multivitamin and calcium self-emulsifying composition. Background technique [0002] Calcium is one of the important nutritional elements for the human body. It is the most abundant mineral element in the human body and has very important physiological functions. Among the current calcium supplements, calcium carbonate has become the first choice raw material for calcium supplements at home and abroad because of its low price, high calcium content and safe use. However, calcium carbonate is an insoluble inorganic compound, which is weakly alkaline, and reacts with gastric acid in the body to release Ga 2+ It is absorbed by the human body, but the solution in the gastric juice is limited. Long-term use will consume a large amount of gastric acid and cau...

Claims

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Application Information

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IPC IPC(8): A23L33/16A23L33/155A23L33/15A61K33/06A61P3/14A61K31/19A61K31/191A61K31/593A61K31/122
CPCA23L33/16A23L33/155A23L33/15A61K31/19A61K33/06A61K31/191A61K31/593A61K31/122A61P3/14A23V2002/00A61K2300/00A23V2200/306A23V2250/702A23V2250/7106A23V2250/7144
Inventor 梅兴国
Owner 湖北真奥医药研究院有限公司
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