Method for establishing neuron dendritic spine development mode based on reaction diffusion model

Abstract

The invention provides a method for establishing a neuron dendritic spine development mode based on a reaction diffusion model, which comprises the steps of formulating a dendritic spine shape classification standard by using the neuron dendritic spine shape of a rat brain hippocampus, simulating the growth process of a single dendritic spine under different conditions by using the reaction diffusion model, classifying simulation results by using a shape classification standard, and further simulating a process of growing dendritic spines with different densities by using the reaction diffusion model under different conditions so as to obtain neuron dendritic spines with different modes. Compared with an existing research method, a large number of animal experiments are effectively avoided; and meanwhile, the reaction diffusion model is applied to the establishment process of the neuron dendritic spine development mode for the first time, and a foundation is laid for subsequent research on the pathogenesis of diseases caused by abnormal dendritic spine modes.

Description

technical field [0001] The invention relates to the field of biological models of neuron dendritic spines, in particular to a method for establishing a developmental model of neuron dendritic spines based on a reaction-diffusion model and its application in disease mechanism analysis. Background technique [0002] Dendritic spines are tiny protrusions on the dendrites of neurons that are widely found in the dendrites of higher animals and play an important role in the formation of most excitatory axon-dendritic synapses. Dendritic spines are generally divided into four patterns: elongated, columnar, mushroom, and branched. Among them, the elongated dendritic spines have high plasticity, which is related to learning; the mushroom-shaped dendritic spines show weak plasticity, which is related to memory function. Abnormal patterning of dendritic spines is associated with a variety of neurological disorders. For example, there are too many elongated dendritic spines in the som...

AI Technical Summary

Problems solved by technology

This type of research mainly has the following shortcomings: (1) a large number of anatomical animal experiments are required; (2) only one factor affecting the dendritic spine pattern is proposed at a time, and the formation of dendritic spines is a dynamic process involving multiple chemical reactions , is regulated by many factors

[0005]Currently, there are two main types of numerical simulation methods used to study dendritic spine patterns: (1) Brownian motion model is used to simulate the volume of dendritic spines, but Brownian motion The model describes a stochastic phenomenon, whereas pattern formation of dendritic spines is a genetically and environmentally regulated process rather than a stochastic process; (2) to study the relationship between cytoskeleton-generated forces and membrane deformation, but This approach lacks an explanation of why the cytoskeleton produces different forces

Moreover, in the process of numerical simulation, these methods distinguish different patterns of dendritic spines by artificial recognition, which inevitably introduces subjective errors.

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