Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pullulan and starch plant enteric capsule and preparation method thereof

A pullulan polysaccharide and starch plant technology, applied in the field of enteric-coated capsules, can solve problems such as easy breakage, insufficient toughness, and difficulty in drying, and achieve the effects of preventing cracking, quick release, and drying

Inactive Publication Date: 2021-03-30
HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of pullulan in hollow capsules also has the problems of insufficient toughness, easy breakage, and difficulty in drying

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pullulan and starch plant enteric capsule and preparation method thereof
  • Pullulan and starch plant enteric capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The propullan poly sugar, starch plant enteric capsule, contains the following mass,

[0045] Delancarose 0.5kg;

[0046] Hydroxypropylttamer 0.5kg;

[0047] Hydroxypropylketolane 0.5kg;

[0048] 0.1 kg of endocene;

[0049] Dose sodium sulfate is 0.1 kg;

[0050] The balance is purified;

[0051] The total mass fraction is 100%.

[0052] The preparation method includes the following steps:

[0053] (1) Raw material selection: select the raw material according to the proportion of components;

[0054] (2) Glue hydrolyzate: Pulan poly sugar, hydroxyproplatin, hydroxypropylene cellulose, intestinal solvent pore, gel, surfactant, colorant, and colorant in a corresponding proportion of purified water, stir well Make it fully dissolved, stand for standby;

[0055] (3) The primary capsystem is prepared: will stabilize the glue, send it to the capsule production line, and prepare it into an initial capsule;

[0056] (4) Capsule prepared: the primary vesicles were immersed in a hyd...

Embodiment 2

[0058] The propullan poly sugar, starch plant enteric capsule, contains the following mass,

[0059] Puulano 2kg;

[0060] Hydroxypropyltransin 2kg;

[0061] Hydroxypropylttellulose 2kg;

[0062] Intestinal soluble pore agent 0.4 kg;

[0063] Carrageena 0.8kg;

[0064] Tween-80 0.4kg;

[0065] Iron oxide red 0.1kg;

[0066] The balance is purified;

[0067] The total mass fraction is 100%.

[0068] The intestinal soluble aperture is used to dissolve the carboxymethylcellulose in the solvent, and calcium gluconate is stirred, and the mixed uniform spray granulation is mixed, and it can be obtained.

[0069] The preparation method includes the following steps:

[0070] (1) Raw material selection: select the raw material according to the proportion of components;

[0071](2) Glue hydrolyzate: Pulan poly sugar, hydroxyproplatin, hydroxypropylene cellulose, intestinal solvent pore, gel, surfactant, colorant, and colorant in a corresponding proportion of purified water, stir well Make i...

Embodiment 3

[0075] The propullan poly sugar, starch plant enteric capsule, contains the following mass,

[0076] Puulan sugar 2.5kg;

[0077] Hydroxypropylttamer 2.5kg;

[0078] Hydroxypropylketellulose 2.5kg;

[0079] Intestinal soluble pore agent 0.5kg;

[0080] Konjac glue 1kg;

[0081] Sodium diternatyl sulfosuccinate 0.5kg;

[0082] Iron oxide red 0.15kg;

[0083] The balance is purified;

[0084] The total mass fraction is 100%.

[0085] The intestinal soluble aperture uses the following method: dissolve the glycerol in the solvent, then add calcium citrate to stir, mix uniformly, spray granulation, dried.

[0086] The preparation method includes the following steps:

[0087] (1) Raw material selection: select the raw material according to the proportion of components;

[0088] (2) Glue hydrolyzate: Pulan poly sugar, hydroxyproplatin, hydroxypropylene cellulose, intestinal solvent pore, gel, surfactant, colorant, and colorant in a corresponding proportion of purified water, stir well Ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of polymerizationaaaaaaaaaa
Login to View More

Abstract

The invention provides a pullulan and starch plant enteric capsule and a preparation method thereof; based on the pullulan and the starch, due to the advantage that the pullulan is good in water locking performance, the defect that the starch is poor in water locking performance and prone to embrittlement is overcome, the prepared enteric capsule is convenient to dry, and meanwhile, reasonable moisture content is kept in the long-time storage and transfer process, and cracking is prevented; since the pullulan and starch both have the problem of insufficient toughness, the problem can be well solved by adding hydroxypropyl methylcellulose; in addition, the enteric pore-foaming agent with the core material wrapped in the wall material is adopted, the wall material is made of a slow materialwith poor enteric solubility; when calcium salt or sylvite is released after the capsule is decomposed in the intestinal tract and is easily dissolved in water, the calcium salt can react in an alkaline environment and form pores quickly, and quick release of drug properties is facilitated.

Description

Technical field [0001] The present invention relates to the field of enteric solvent, and more particularly to a propullan poly sugar, a starch plant enteric capsule and a preparation method thereof. Background technique [0002] The current hollow capsule is mainly based on gelatin as the main raw material, gelatin is an animal's skin, bone, tendon and ligament of collagen not fully acid hydrolysis, alkali hydrolysis or enzyme-degradation purification, has good crisp, collapse Device and other performance, so it is widely used in the current capsule market, but the gelatin material has a certain problem, which mainly comes from the mammal, there is a risk of carrying viruses; and high water content, temperature and humidity Sensitive, when in high humidity, high temperature, there is aldehyde substance or an ultraviolet irradiation, it may also occur, and the crosslinked gelatin is not easily dissolved in water, which will affect the disintegration and dissolution of the capsule...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38
CPCA61K9/4891A61K9/4816A61K47/36A61K47/38
Inventor 黄建华孙平飞黄猛任海民柯丽烂卢大林周峰詹欢欢闫莹莹
Owner HUBEI HUMANWELL PHARMACEUTICAL EXCIPIENTS CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com