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Probiotic bacteriostatic gel and preparation method thereof

A technology of probiotics and gel, which is applied in the field of medicine, can solve the problems of unscientific and destroying the weak acidic environment of the vagina, and achieve the effects of improving vaginal verification, enhancing vaginal immunity and metabolism, and improving fermentation efficiency

Inactive Publication Date: 2021-03-26
江西长通实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are some lotion needles that can clean the vagina and vulva, but these lotions contain surfactants and are mostly alkaline or neutral. It is unscientific to wash with alkaline shower gel or tap water. Frequent use of lotions , disinfection pads, etc., are also easy to destroy the weak acidic environment of the vagina

Method used

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  • Probiotic bacteriostatic gel and preparation method thereof
  • Probiotic bacteriostatic gel and preparation method thereof
  • Probiotic bacteriostatic gel and preparation method thereof

Examples

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preparation example Construction

[0070] The preparation process of dication type acidic ionic liquid, such as figure 2 Shown, with ionic liquid [Ps 2 TMEDA][BF 4 ] 2 synthesis as an example.

[0071] Add tetramethylethylenediamine and ethanol (ratio of 1mol:1L) to the reactor respectively, preheat at 70°C; add 1,3-propane sultone (tetramethyl 2 times the amount of ethylenediamine), after the dropwise addition was completed, stirring was continued for 8h to obtain a large amount of intermediate product (white solid). After the reaction was completed, the intermediate product was repeatedly washed with ether for 3-5 times to remove unreacted raw materials, and then dried in a vacuum oven at 80°C for 12 hours.

[0072] Add the intermediate product into the reactor, preheat at 70°C, then add tetrafluoroboric acid solution (2 times the amount of tetramethylethylenediamine) into the reactor dropwise, and continue stirring for 10h. After the reaction finishes, the water in the reaction mixture is removed by rota...

Embodiment 1

[0077] A kind of antibacterial gel, comprising: after [Ps 2 TMEDA][BF 4 ] 2 Fermented traditional Chinese medicines, probiotics, pH regulators, nutritional moisturizers, thickeners, chelating agents and deionized water catalyzed by the fermentation of microbial agents.

[0078] Its preparation method comprises the following steps:

[0079] S1. Weigh the following traditional Chinese medicines according to the proportion of the formula: 20 parts of Cortex Phellodendri, 50 parts of Sophora Sophora, 30 parts of Radix Paeoniae Rubra, 40 parts of Dandelion, 30 parts of Cnidium Fructus, 10 parts of Centella Asiatica, 10 parts of Dipsacus, 10 parts of Eucommia Leaf 10 parts, 10 parts of fennel, 20 parts of comfrey, 20 parts of borneol, 20 parts of angelica, 20 parts of guava leaves, mixed and crushed, sterilized;

[0080] S2, adding 1% of the total mass of traditional Chinese medicine [Ps 2 TMEDA][BF 4 ] 2 As a fermentation catalyst, add 10% deionized water to remove the total ...

Embodiment 2

[0087] A kind of antibacterial gel, comprising: after [Ps 2 TMEDA][HSO 4 ] 2 Fermented traditional Chinese medicines, probiotics, pH regulators, nutritional moisturizers, thickeners, chelating agents and deionized water catalyzed by the fermentation of microbial agents.

[0088] Its preparation method comprises the following steps:

[0089] S1. Weigh the following traditional Chinese medicines according to the proportion of the formula: 40 parts of Cortex Phellodendri, 30 parts of Sophora Sophorae, 30 parts of Radix Paeoniae Rubra, 25 parts of Dandelion, 25 parts of Cnidium Fructus, 25 parts of Centella Asiatica, 25 parts of Dipsacus, 20 parts of Eucommia Leaf 20 parts, 20 parts of fennel, 10 parts of comfrey, 10 parts of borneol, 10 parts of angelica, 10 parts of guava leaves, mixed and crushed, sterilized;

[0090] S2, adding 1.5% of the total mass of traditional Chinese medicine [Ps 2 TMEDA][HSO 4 ] 2 and 0.5% saccharomyces, 0.5% Acetobacter xylinum, and 0.5% Lactobac...

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Abstract

The invention provides probiotic bacteriostatic gel and a preparation method thereof, and relates to the technical field of medicines. The probiotic bacteriostatic gel comprises fermented traditionalChinese medicines, probiotics, a pH regulator, a humectant, a thickener, a chelating agent and deionized water which are fermented and catalyzed by a dication type acidic ionic liquid and a microbialagent. The method comprises the following steps: S1, weighing traditional Chinese medicines according to a formula ratio, mixing, crushing and sterilizing; S2, adding a fermentation catalyst and deionized water for fermentation; S3, filtering the fermented traditional Chinese medicine mixture to obtain liquid medicine, and concentrating the liquid medicine to obtain fermented traditional Chinese medicine; and S4, mixing the fermented traditional Chinese medicine with the probiotics, the pH regulator, the nutritional humectant, the thickener, the chelating agent and the deionized water to prepare the probiotic bacteriostatic gel. By inhibiting the growth of harmful bacteria and regulating the growth and propagation of vaginal probiotics, the vaginal micro-ecological environment of vaginitispatients is improved, and the disease recurrence is reduced. The preparation method is simple and beneficial to industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a probiotic antibacterial gel and a preparation method thereof. [0002] [Ps 2 TMEDA][BF 4 ] 2 Refers to N,N'-dipropylsulfonic acid group-N,N,N',N'-tetramethylethylenediammonium tetrafluoroborate, and the names of other ionic liquids with different anions are analogous; [0003] [Bs 2 TMEDA][BF 4 ] 2 It refers to N,N'-dibutylsulfonic acid group-N,N,N',N'-tetramethylethylenediammonium tetrafluoroborate, and the names of other ionic liquids with different anions are analogous. Background technique [0004] The vaginal flora plays an irreplaceable role in maintaining the stability and regulation of the vaginal environment. The vaginal flora is very complex. In addition to protozoa and fungi, it also includes many aerobic bacteria and anaerobic bacteria, such as Streptococcus lactis, Enterobacter, Proteus, Gafferkycoccus, and Veillonella, which are common in the lower vagina....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61K47/18A61K47/38A61K47/36A61K47/42A61P15/02A61P15/00A61P31/02A61K31/045A61K35/745A61K35/747
CPCA61K9/0034A61K9/06A61K31/045A61K35/745A61K35/747A61K36/185A61K36/23A61K36/232A61K36/234A61K36/288A61K36/30A61K36/46A61K36/487A61K36/489A61K36/61A61K36/65A61K36/71A61K36/756A61K47/183A61K47/36A61K47/38A61K47/42A61K2236/19A61K2236/333A61P15/00A61P15/02A61P31/02A61K2300/00
Inventor 杜俊勇杜立刚
Owner 江西长通实业有限公司
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