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Chromosome karyotype analysis system

A technology of chromosome karyotype and analysis system, applied in the field of artificial intelligence, can solve problems such as inability to meet the needs of clinical work, insufficient accuracy, and long time-consuming

Active Publication Date: 2021-03-16
ZHENGZHOU UNIV
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Problems solved by technology

The current classification method is time-consuming, inefficient, and insufficient in accuracy and cannot meet the needs of clinical work

Method used

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  • Chromosome karyotype analysis system
  • Chromosome karyotype analysis system
  • Chromosome karyotype analysis system

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Embodiment Construction

[0097] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0098] Such as figure 2 As shown, a karyotype analysis system, including

[0099] 1) Design filtering algorithms and segmentation algorithms to filter and remove impurities from human metaphase cell images and extract chromatids;

[0100] (2) Design the identification algorithm and correction algorithm to identify and pair the extracted chromosomes to generate a karyotype map.

[0101] This embodiment takes image 3 Taking the chromosome karyotype...

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Abstract

The invention relates to a chromosome karyotype analysis system which comprises the following steps: (1) designing a filtering algorithm and a segmentation algorithm to filter and remove impurities from a human metaphase cell image, and extracting a staining monomer; and (2) designing an identification algorithm and a correction algorithm, and identifying and pairing the extracted chromosomes so as to generate a karyotype map. According to the invention, the karyotype analysis method is combined with image processing, machine learning and other technologies, a reliable chromosome karyotype automatic analysis system is developed, automation and intelligence of chromosome karyotype analysis are realized, and the efficiency and the accuracy of chromosome karyotype classification are integrally improved.

Description

technical field [0001] The invention belongs to the technical field of artificial intelligence, and specifically relates to a chromosome karyotype analysis system, which is applied to the research on the mechanism of human genetic diseases, species kinship and evolution, tumor pathology and the like. Background technique [0002] Human somatic cells generate chromosomes in metaphase of mitosis, normally there are 46 chromosomes (22 pairs of autosomes and a pair of sex chromosomes). Chromosomes are carriers of genetic material, and abnormalities in their number or structure can lead to genetic diseases. Chromosomal karyotype analysis is of great significance in exploring the mechanism of human genetic diseases, species kinship and evolution, and tumor pathology research. Such as figure 1 As shown, karyotyping refers to the grouping, alignment, and pairing of chromosomes in human metaphase cell images and the generation of karyotype maps. [0003] Early chromosome karyotype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00G06T7/12G06T7/13G06T7/62
CPCG06T7/0012G06T7/12G06T7/13G06T7/62G06T2207/10056G06T2207/30072
Inventor 梁静岳彩通于坤杰瞿博阳杨昊天胡毅李鹏帅李功平
Owner ZHENGZHOU UNIV
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