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Blueberry powder compound solid preparation capable of preventing and improving Alzheimer's disease as well as preparation method and application of blueberry powder compound solid preparation

A kind of Alzheimer's disease, solid preparation technology, applied in the direction of application, food ingredients as taste improvers, medical preparations containing active ingredients, etc., can solve the problems of uncertain curative effect, large toxic and side effects, muscle cramps, etc., and achieve prevention and treatment Improving the effect of dementia

Pending Publication Date: 2021-03-12
浙江蓝美生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of them are still in clinical trials, the curative effect is uncertain, and the side effects are large.
In addition, because these drugs usually increase the content of acetylcholine in the brain by reducing the decomposition rate of acetylcholine, it is easy to cause nausea and vomiting, and sometimes even cause muscle cramps, slow heartbeat, decreased appetite, and hyperacidity. reaction
Due to the above reasons, people are trying to find a new green therapy for dementia, but up to now, foods and special foods with comprehensive prevention and improvement effects on vascular dementia, Alzheimer's dementia and Parkinson's dementia are still unavailable. Blank

Method used

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  • Blueberry powder compound solid preparation capable of preventing and improving Alzheimer's disease as well as preparation method and application of blueberry powder compound solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] First, 80 parts by weight of blueberry powder, 50 parts of nobiletin, 35 parts of γ-aminobutyric acid and 35 parts of tea theanine were weighed, put into a mixing container and mixed evenly to obtain a mixed powder. Next, the obtained mixed powder is subjected to wet granulation or dry granulation and sizing, and the sizing size is 10 mesh to obtain mixed granules. Subsequently, the obtained mixed particles are dried at a low temperature below 50° C., pulverized and sieved, and the sieve mesh is 120 mesh to obtain a sieved powder. Finally, the metal foreign matter in the obtained sieved powder is removed by the iron remover, and then the metal detection inspection is carried out after the inner packaging is carried out in a food-grade or pharmaceutical-grade PE bag, and then the ultra-high pressure disinfection method is used for disinfection, and the outer packaging is carried out. to get the finished product.

[0041] Among them, the blueberry powder is made of wild ...

Embodiment 2

[0045] Weigh 40 parts of blueberry powder, 15 parts of nobiletin, 20 parts of γ-aminobutyric acid and 20 parts of tea theanine.

[0046] The sieving mesh is 100 mesh, and the disinfection method is hot water pasteurization, and the others are the same as in Embodiment 1.

[0047] The finished product obtained in the above steps can be used as a raw material, and can be prepared into common food, health food or medicine after appropriate addition of auxiliary materials such as food additives and auxiliary agents.

[0048] For example, add 16.8 parts by weight of purified water into a hot water heating jacketed stirring tank and heat it to 50°C, add 37 parts by weight of glycerin fatty acid ester, 68 parts of sunflower Seed oil and 100 parts of krill oil are put into this tank after mixing evenly and continue to stir, then add gelatin with a weight ratio of 141.02 parts, after the gelatin is completely dissolved, continue to put in a weight ratio of 52.18 parts of glycerin, and ...

Embodiment 3

[0050] Weigh 60 parts of blueberry powder, 50 parts of nobiletin, 30 parts of γ-aminobutyric acid and 60 parts of tea theanine.

[0051] The sieving mesh number is 80 orders, and others are the same as embodiment one.

[0052] The finished product obtained in the above steps can be used as a raw material, and can be prepared into common food, health food or medicine after appropriate addition of auxiliary materials such as food additives and auxiliary agents.

[0053] For example, add 1200 parts by weight of purified water to a hot water heating jacketed stirring tank and heat it to 38°C, add 30 parts by weight of modified soybean lecithin and 15 parts of alginic acid to the finished blueberry powder compound solid preparation Potassium, after being mixed evenly, drop into this tank and continue to stir, then weigh 120 parts by weight of non-energy sweetener, 50 parts of citric acid and 50 parts of L-malic acid, and use 500 parts by weight together The purified water is disso...

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Abstract

The invention discloses a blueberry powder compound solid preparation capable of preventing and improving Alzheimer's disease as well as a preparation method and application of the blueberry powder compound solid preparation. The blueberry powder compound solid preparation capable of preventing and improving Alzheimer's disease comprises the following components in parts by weight: 10 to 90 partsof blueberry powder, 5 to 50 parts of nobiletin, 5 to 50 parts of gamma- aminobutyric acid and 5 to 60 parts of tea theanine. The preparation method of the blueberry powder compound solid preparationcapable of preventing and improving Alzheimer's disease comprises the steps of a) mixing, b) granulating, c) crushing, and d) post-treating. All components of the blueberry powder compound solid preparation prepared by the invention are common foods, medicinal and edible substances, new food raw materials, new food raw material termination examination substances, food additives and other substances allowed to be eaten by laws and regulations, and meanwhile, for vascular dementia, Alzheimer type dementia and Parkinson dementia, the blueberry powder compound solid preparation has the effects ofcomprehensively preventing and improving Alzheimer's disease.

Description

【Technical field】 [0001] The invention relates to the technical field of compound solid preparations, in particular to the technical field of a blueberry powder compound solid preparation capable of preventing and improving senile dementia, its preparation method and application. 【Background technique】 [0002] Alzheimer's disease refers to the comprehensive impairment of persistent higher neurological functions in conscious people due to various diseases, including impairment of memory, ability to solve problems of daily life, acquired skills, correct social skills, and ability to control emotions , an acquired syndrome that culminates in mental decline. Senile dementia mainly includes vascular dementia (VD), Alzheimer's dementia (AD) and Parkinson's dementia. [0003] Senile cognitive decline is a pre-stage of senile dementia. If nutrition intervention is carried out as soon as possible, the occurrence and development of senile dementia can be effectively delayed. Theref...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61P25/28A23L33/105A23L33/175A23G3/48A23G3/44A23G3/36A23L21/10A23L2/38A61K31/198A61K31/197A61K31/352
CPCA23G3/364A23G3/44A23G3/48A23L2/38A23V2002/00A61K31/197A61K31/198A61K31/352A61K36/45A23L21/10A23L33/105A23L33/175A61P25/28A61K2300/00A23V2200/322A23V2250/038A23V2250/0646A23V2250/21A23V2250/2106A23V2200/16A23V2250/5114A23V2250/51084A23V2250/5432A23V2250/5026A23V2250/044A23V2250/032
Inventor 杨雪峰
Owner 浙江蓝美生物技术有限公司
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