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A kind of traditional Chinese medicine composition with effect of improving cognition and its preparation method and traditional Chinese medicine preparation

A technology for improving cognition and traditional Chinese medicine preparations, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as incomplete medicinal ingredients, and achieve improved brain cognition, Improving brain cognition and improving the effect of Alzheimer's disease

Active Publication Date: 2021-12-24
GANSU CHENLAN BIOMEDICAL CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction of medicinal ingredients in this prescription is not complete enough, and other public technologies rarely mix the volatile oil with the Chinese medicine extract after inclusion

Method used

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  • A kind of traditional Chinese medicine composition with effect of improving cognition and its preparation method and traditional Chinese medicine preparation
  • A kind of traditional Chinese medicine composition with effect of improving cognition and its preparation method and traditional Chinese medicine preparation
  • A kind of traditional Chinese medicine composition with effect of improving cognition and its preparation method and traditional Chinese medicine preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Chinese medicine composition and preparation method thereof

[0043] 1, the present embodiment formula is:

[0044] Gastrodia elata 180g, polygala 120g, calamus 180g, cistanche 60g, rehmannia glutinosa 60g, curcumin 1g.

[0045] 2. The preparation method is:

[0046] (1) Gastrodia elata and polygala plus 10 times the amount of 70% ethanol were heated and refluxed for 3 times, each time for 1 hour, and the medicinal liquid and dregs were collected respectively;

[0047] (2) add 14 times the amount of water to Acorus calamus, heat and reflux once for 5 hours, and collect the medicinal liquid, medicinal residues and volatile oil respectively;

[0048] (3) add Cistanche deserticola, rehmannia glutinosa and the traditional Chinese medicine dregs collected in steps (1) and (2) to 10 times the amount of water, heat and reflux twice, each time for 1.5 hours, and collect the liquid medicine respectively;

[0049] (4) filtering and concentrating all the medicinal ...

Embodiment approach

[0101] Implementation method: The test program includes two parts: directional navigation and space exploration. A total of 5 days of continuous testing. The first part is the positioning navigation experiment, and the mice are tested for 4 days, and the second part is the space exploration experiment, and the test is carried out for 1 day. The black vegan toner was rinsed away in warm water to hide the platform and to keep it in sharp contrast with the color of the mice for easy tracking. The platform is located 0.8 cm below the water surface, the water depth is 21 cm high, and is positioned in the NW quadrant. The water temperature in the water maze is maintained at a constant temperature of 22-24 °C with a heating rod.

[0102] Orientation navigation experiment: Each mouse was trained 4 times / d, and the time interval between each training was 15-20 min. During the test, the water entry point was selected in a semi-random manner each time. The experimenter held the mice up...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of improving cognition, a preparation method thereof and a traditional Chinese medicine preparation. In parts by weight, the traditional Chinese medicine composition is made of the following raw materials: 1-20 parts of Gastrodia elata, 1-15 parts of polygala, 1-30 parts of calamus, 0.1-10 parts of Cistanche, 0.1-10 parts of Rehmannia glutinosa, 0.01 parts of curcumin ~ 1 serving. The present invention adopts the composite extraction method to extract the prescription, and extracts the effective substances of Gastrodia elata, Polygala, Shichangpu, Cistanche, and Rehmannia glutinosa as completely as possible, concentrates and dries them; The dry powder of the compound extract and the clathrate of the volatile oil are evenly mixed to form the final traditional Chinese medicine composition. The compound Chinese medicine of the invention has been proved by pharmacological experiments to have the effect of improving brain cognition.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with the effect of improving cognition, a preparation method and a traditional Chinese medicine preparation. Background technique [0002] As the aging trend of the world increases year by year, mild cognitive impairment (MCI) and vascular cognitive impairment (VCI), which are transition states from normal aging to dementia, are more and more popular among people. focus on. In developed countries, the death rate of Alzheimer's disease ranks fourth after heart disease, cancer and stroke. With the aging of the world's population, the disease has become one of the most serious problems facing geriatrics today. Mild cognitive impairment in the early stages of Alzheimer's is recognized as a highly prevalent and preventable syndrome. Currently, there is no effective treatment for Alzheimer's patients. FDA-approved dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P25/00A61K31/12
CPCA61K36/8988A61K36/69A61K36/888A61K36/64A61K36/804A61K31/12A61P25/00A61K2300/00A61K36/882A61K47/6951A61K2236/331A61K2236/333A61K2236/37A61K2236/53A61K36/9066A61K9/5036A61K9/0053
Inventor 张曾亮王尚龙李鑫宗磊宗建成邹圣灿
Owner GANSU CHENLAN BIOMEDICAL CO LTD
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