Application of Zukamu granules in lung injury caused by cytokine storm

A technology of cytokines and zuccam, applied in the field of lung injury, can solve the problems of undeveloped specific drugs and specific treatment methods

Inactive Publication Date: 2021-02-12
新疆维吾尔药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of therapeutic drugs, no specific drugs and specific treatments have been developed yet.

Method used

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  • Application of Zukamu granules in lung injury caused by cytokine storm
  • Application of Zukamu granules in lung injury caused by cytokine storm
  • Application of Zukamu granules in lung injury caused by cytokine storm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Effect of Zukamu Granules on Mouse Ear Swelling Caused by Xylene and Its Mechanism of Action

[0057] On the second day after the adaptive feeding, 48 Kunming mice were weighed and randomly divided into 6 groups according to the random number table method, which were blank control group, model group, positive drug DEX group and Zukamu low, medium and High dose group (n=8). The mice in the low, medium and high dose groups of Zukamu were given Zukamu intragastric intervention treatment (1.35g / kg, 2.7g / kg, 5.4g / kg, equivalent to the human dose of 9g / 60kg, 18g / 60kg, 36g / 60kg), administered continuously for 5 days, once a day; the control group and the model group were treated with intragastric administration of equal volume of normal saline every day; , and the dosage is 5mg / kg. One hour after the end of administration on the fifth day, 40 μL of xylene solution was evenly applied to both sides of the right auricle of the mice to induce inflammation and swelling...

Embodiment 2

[0063] Example 2 Effects of Zukamu Granules on Acute Lung Injury in Rats Caused by Bacterial Endotoxin LPS and Its Mechanism of Action

[0064] 48 SD rats were weighed and randomly divided into 6 groups, followed by control group, model group, positive drug DEX group (n=8, 5mg / kg) and Zukamu low, middle and high dose groups (n= 8, 1.35g / kg, 2.7g / kg, 5.4g / kg). The doses and methods of administration to animals in each group were the same as those described above. One hour after the end of administration on the 5th day, except for the blank control group injected with an equal volume of normal saline, the mice in other groups were injected with LPS (5 mg / kg) through the tail vein to induce acute lung injury in rats. After 6 hours, the rats were anesthetized with 10% chloral hydrate, the chest cavity was opened to separate the lung tissue, the left lung was ligated at the left main bronchus, and the trachea was intubated. % indicates qualified. The collected mixture was centri...

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Abstract

The invention discloses an application of Zukamu granules. The application is, for example, an application in lung injury caused by cytokine storm. The inventor accidentally finds that the Zukamu granules can significantly reduce the secretion level of inflammatory factors in tissues, and can be effectively applied to treatment of inflammation; especially, the Zukamu granules have a remarkable inhibiting effect on inflammatory pathological injury of lung tissues, and effectively improve the inflammatory pathological injury of the lung tissues. Moreover, the medicine is rigorous in structure, small in liver burden and small in toxic and side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to the application of Zukamu granules in lung injury, especially the application of Zukamu granules in lung injury caused by cytokine storm. Background technique [0002] Acute lung injury (ALI) is the injury of alveolar epithelial cells and capillary endothelial cells caused by various direct and indirect injury factors, resulting in diffuse pulmonary interstitial and alveolar edema, resulting in acute hypoxic respiratory insufficiency . The pathophysiological features are reduced lung volume, decreased lung compliance, and imbalance of ventilation / perfusion flow ratio, clinically manifested as progressive hypoxemia and respiratory distress, and lung imaging manifested as heterogeneous exudative lesions , and its development to a severe stage (oxygenation index <200) is called acute respiratory distress syndrome (acute respiratory distress syndrome, ARDS)...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K9/16A61P11/00A61P29/00
CPCA61K36/906A61K36/62A61K36/534A61K36/725A61K36/28A61K36/30A61K36/484A61K36/185A61K36/708A61K36/66A61K9/1623A61P11/00A61P29/00A61K2300/00
Inventor 尹强尹海龙韩林涛穆丹丹侯帅红周琴田芳宋菲麦麦提艾力·依甘拜尔迪王丽敏杜冰洁姜大军张鹏
Owner 新疆维吾尔药业有限责任公司
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