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A method for preparing multiple pickering emulsions from crystalline block copolymer micelles

A technology of block copolymers and copolymers, which is applied in the direction of emulsion transportation, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of hazards, solid particles are not easy to be degraded, etc., achieve good barrier properties, overcome oil Effect of excess soluble emulsifier, good emulsion stability

Active Publication Date: 2022-06-28
QUZHOU RES INST OF ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention aims to overcome the defect that the solid particles in the Pickering emulsion system in the prior art are not easy to be degraded, and at the same time overcome the deficiency that small molecule emulsifiers cause harm to the human body

Method used

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  • A method for preparing multiple pickering emulsions from crystalline block copolymer micelles
  • A method for preparing multiple pickering emulsions from crystalline block copolymer micelles
  • A method for preparing multiple pickering emulsions from crystalline block copolymer micelles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Block copolymer PEG 2k -PCL 19.4k and PCL 1.9k -PEG 20k -PCL 1.9k Preparation of:

[0061] PEG 2k -PCL 19.4k Preparation of block copolymer: 0.5g polyethylene glycol monomethyl ether (average molecular weight is 2000Da), 5g ε-caprolactone monomer, 0.028g stannous octoate are placed in a dry flask, under argon protection , react at 120 °C for 12 hours; after the reaction, drop the reaction mixture into ice-n-hexane for precipitation, filter and dry to obtain PEG 2k -PCL 19.4k block copolymer.

[0062] PCL 1.9k -PEG 20k -PCL 1.9k Preparation of block copolymer: 2.5g polyethylene glycol (average molecular weight is 20000Da), 0.5g ε-caprolactone monomer, 0.015g stannous octoate are placed in a dry flask, under argon protection, in The reaction was carried out at 120°C for 12 hours; after the reaction, the reaction mixture was dropped into ice-n-hexane for precipitation, filtered and dried to obtain PCL 1.9k -PEG 20k -PCL 1.9k block copolymer.

[0063] Th...

Embodiment 2

[0069] (1) Block copolymer PCL 5.1k -PEG 8k -PCL 5.1k , PDLA5.8k -PEG 5k -PDLA 5.8k and PLLA 3k -PEG 10k -PLLA 3k Preparation of:

[0070] PCL 5.1k -PEG 8k -PCL 5.1k Preparation of block copolymer: 4g polyethylene glycol (average molecular weight is 8000Da), 5g ε-caprolactone monomer, 0.045g stannous octoate were placed in a dry flask, under argon protection, at 120 ° C The reaction was carried out for 12 hours; after the reaction, the reaction mixture was dropped into ice-n-hexane for precipitation, filtered and dried to obtain PCL 5.1k -PEG 8k -PCL 5.1k block copolymer.

[0071] PDLA 5.8k -PEG 5k -PDLA 5.8k Preparation of block copolymer: 2.08g polyethylene glycol (average molecular weight is 5000Da), 5g d-lactide monomer, 0.035g stannous octoate were placed in a dry flask, under argon protection, at 120 The reaction was carried out at °C for 12 hours; after the reaction was completed, the reaction mixture was dropped into ice-n-hexane to precipitate, filter...

Embodiment 3

[0079] (1) Block copolymer PEG 2k -PGA 5.2k , PEG 5k -PDLA 8k and PLLA 3.7k -PEG 5k -PLLA 3.7k Preparation of:

[0080] PEG 2k -PGA 5.2k Preparation of block copolymer: 2g polyethylene glycol monomethyl ether (average molecular weight is 2000Da), 5g glycolide monomer, 0.035g stannous octoate are placed in a dry flask, under argon protection, at 120 The reaction was carried out at ℃ for 12 hours; after the reaction, the reaction mixture was dropped into ice-n-hexane for precipitation, filtered and dried to obtain PEG 2k -PGA 5.2k block copolymer.

[0081] PEG 5k -PDLA 8k Preparation of block copolymer: 3.13g polyethylene glycol monomethyl ether (average molecular weight is 5000Da), 5g D-lactide monomer, 0.041g stannous octoate are placed in a dry flask, under argon protection , react at 120 °C for 12 hours; after the reaction, drop the reaction mixture into ice-n-hexane for precipitation, filter and dry to obtain PEG 5k -PDLA 8k block copolymer.

[0082] PLLA 3...

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Abstract

The invention relates to the technical fields of chemical engineering and biological preparations, and discloses a method for preparing multiple Pickering emulsions from crystalline block copolymer micelles, including (1) polymerizing hydrophilic macromolecules and hydrophobic monomers to obtain hydrophilic Block copolymer and hydrophobic block copolymer; (2) prepare again the water dispersion liquid A of hydrophobic block copolymer micelle and the water dispersion B of hydrophilic block copolymer micelle; (3) water Dispersion A is mixed with the oil phase at high speed to obtain W 1 / O Type Pickering Emulsion; (4)W 1 / O-type Pickering emulsion mixed with water dispersion B at high speed to obtain W 1 / O / W 2 Type Multiple Pickering Emulsion. The invention does not rely on any small molecule emulsifiers, and only uses biodegradable block copolymer micelles as particle emulsifiers to obtain multiple Pickering emulsions, which not only have good emulsion stability, but also have biodegradability, which can better Apply this double Pickering emulsion to fields such as biopharmaceutical preparations.

Description

technical field [0001] The invention relates to the technical fields of chemical and biological preparations, in particular to a method for preparing multiple Pickering emulsions from crystalline block copolymer micelles. Background technique [0002] Amphiphilic block copolymers refer to block copolymers containing both hydrophilic and hydrophobic segments in the same polymer chain. The different blocks of amphiphilic block copolymers are usually thermodynamically incompatible and can undergo microphase separation, but the phase separation is limited to the microscopic size range due to covalent interactions between the blocks. In selective solvents, due to the difference in solubility of different blocks, when the concentration of the copolymer exceeds the critical micelle concentration (CMC), the amphiphilic block copolymer can form self-assembled structures such as core-shell micelles. , drug sustained release, stable emulsion and other fields have good application pros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/113A61K47/10A61K47/34
CPCA61K9/113A61K47/34A61K47/10
Inventor 单国荣林超胡镜潘鹏举
Owner QUZHOU RES INST OF ZHEJIANG UNIV
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