Axitinib-loaded nanofiber membrane as well as preparation method and application thereof to surgical postoperative adhesion prevention

A nanofiber membrane and surgical technique, applied in the field of biomedical materials, can solve problems such as excessive pericardial bleeding, and achieve the effects of short time consumption, low cost and stable structure

Active Publication Date: 2021-01-12
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another example is the topical use of plasminogen activator for the second stage, although it can promote the degradation of fibrin, but it will lead to excessive bleeding in the pericardial cavity, and there are few clinical application reports

Method used

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  • Axitinib-loaded nanofiber membrane as well as preparation method and application thereof to surgical postoperative adhesion prevention
  • Axitinib-loaded nanofiber membrane as well as preparation method and application thereof to surgical postoperative adhesion prevention
  • Axitinib-loaded nanofiber membrane as well as preparation method and application thereof to surgical postoperative adhesion prevention

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 0.5 gram of gelatin and 0.5 gram of polycaprolactone, dissolve them in 10 ml of trifluoroethanol, add 30 microliters of acetic acid into the solution, stir until they are evenly mixed, and prepare a spinning solution with a mass volume percentage of 10% g / ml. silk liquid.

[0032] A 10ml syringe and a needle with an inner diameter of 1.2mm were used to extract the spinning solution, fixed on an electrospinning device for electrospinning, and a roller was used as a receiving device to obtain a gelatin / polycaprolactone nanofiber membrane. The parameters in the spinning process are set as follows: voltage 5-50kv, receiving distance 5-30cm, injection rate 0.5-10ml / h, temperature 10-40°C, relative humidity 20-80%.

Embodiment 2

[0034] Weigh 100 mg of Axitinib and dissolve it in 10 ml of trifluoroethanol, and add 40 microliters of acetic acid to the solution, stir until evenly mixed, then add 0.5 gram of gelatin and 0.5 gram of polycaprolactone to the solution to form a mass volume percentage It is 10% g / ml spinning solution.

[0035] A 10ml syringe and a needle with an inner diameter of 1.2mm were used to extract the spinning solution, fixed on an electrospinning device for electrospinning, and a roller was used as a receiving device to obtain a gelatin / polycaprolactone nanofiber membrane loaded with Axitinib. The parameters in the spinning process are set as follows: voltage 5-50kv, receiving distance 5-30cm, injection rate 0.5-10ml / h, temperature 10-40°C, relative humidity 20-80%.

Embodiment 3

[0037] Prepare two spinning solutions of different systems: ① Weigh 100 mg of Axitinib and dissolve it in 10 ml of trifluoroethanol, add 40 microliters of acetic acid to the solution, stir until the mixture is uniform, then add 0.5 g of gelatin and 0.5 The gram of polycaprolactone is made into the spinning solution that the mass volume percentage is 10% g / ml. ② Weigh 0.5 g of gelatin and 0.5 g of polycaprolactone, dissolve them in 10 ml of trifluoroethanol, add 30 microliters of acetic acid into the solution, stir until evenly mixed, and prepare a mixture with a mass volume percentage of 10% g / ml spinning solution.

[0038]Use a 10ml syringe and a needle with an inner diameter of 1.2mm to extract spinning solution ①, fix it on the electrospinning device for electrospinning, use a drum as a receiving device, and after spinning 1ml, extract spinning solution ② and spin 1ml Afterwards, 1 ml of spinning solution ① was re-spun to obtain a gelatin / polycaprolactone nanofiber membran...

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Abstract

The invention discloses an application of a nanofiber membrane loaded with a small molecule drug for inhibiting a vascular endothelial growth factor and / or inhibiting a vascular endothelial growth factor receptor to preparation of a surgical postoperative anti-adhesion medical instrument. The nanofiber membrane has the advantages that the nanofiber membrane provided in the invention is good in biocompatibility, excellent in mechanical property, flexible and smooth after encountering water, good in air permeability and capable of effectively preventing the heart from adhering to surrounding tissues. In addition, the nanofiber membrane can also be applied to adhesion prevention in other surgical operations for abdominal cavities, pelvic cavities, tendons and the like.

Description

technical field [0001] The present application relates to the technical field of biomedical materials, in particular to a nanofibrous membrane loaded with Axitinib, its preparation method and its application in anti-adhesion after surgery. Background technique [0002] Adhesion is one of the common complications after surgery, which can cause serious consequences, such as pelvic and abdominal adhesions can cause intestinal obstruction, pelvic and abdominal pain, infertility and other diseases. Among them, in cardiac surgery, many patients need reoperation or even multiple operations. Due to the adhesion generated in the first operation, the original anatomical layers and gaps disappear, making the second-stage thoracotomy full of hardships and risks. Prevention of postcardiac adhesions can greatly reduce the difficulty of cardiac reoperation, reduce intraoperative and postoperative bleeding, reduce operation time and cost, and even reduce mortality. [0003] For the prevent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382D04H3/02D04H3/005D01D5/00D01F8/14D01F8/02
CPCD04H1/728D04H1/4382D04H3/02D04H3/005D01D5/003D01F8/14D01F8/02D10B2509/00A61P41/00A61K31/4439A61L31/16A61L31/041A61L2300/416A61L2300/434Y02A50/30C08L89/06C08L67/04A61K9/4825A61L2300/204A61L2300/424A61L2400/12
Inventor 张浩冯蓓王鑫钢戴子豪刘一为叶霖财
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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