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Biological 3D printing skin repair stent

A 3D printing and skin repair technology, applied in tissue regeneration, prosthesis, additive processing, etc., can solve the problems of complex and single components, large differences in physical properties and biological activities, etc.

Active Publication Date: 2021-01-12
NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of the epidermis, dermis and subcutaneous tissue layer of real skin is complex, and the components of each layer of the skin repair scaffold in the above-mentioned prior art are too single, and both physical properties and biological activities are quite different.

Method used

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  • Biological 3D printing skin repair stent
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  • Biological 3D printing skin repair stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;

[0054] The hydrogel composition of the epidermis comprises sodium alginate 20 mg / ml, gelatin 18 mg / ml, collagen 5 mg / ml, hyaluronic acid 2 mg / ml, elastin 1 mg / ml, laminin 1 mg / ml, glycerin 80mg / ml, KGF 5ng / ml; the hydrogel composition of the dermis includes sodium alginate 15mg / ml, gelatin 20mg / ml, collagen 10mg / ml, glycerin 60mg / ml, hyaluronic acid 5mg / ml, FGF 10ng / ml; the hydrogel composition of the subcutaneous tissue layer comprises sodium alginate 10mg / ml, gelatin 20mg / ml, collagen 4mg / ml, hyaluronic acid 2mg / ml, VEGF 1.0ng / ml; the mg / ml refers to the mass volume ratio of the corresponding component to the prepared PBS solution.

[0055] The preparation method of the hydrogel of the epidermis is as follows: dissolve hyaluronic acid in PBS, stir for 4 hours to dissolve and mix well, then a...

Embodiment 2

[0063] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;

[0064] The hydrogel composition of the epidermal layer includes sodium alginate 25mg / ml, gelatin 15mg / ml, collagen 10mg / ml, hyaluronic acid 1mg / ml, elastin 0.1mg / ml, laminin 0.1mg / ml, Glycerin 50mg / ml, KGF 1ng / ml; the hydrogel composition of the dermis includes sodium alginate 20mg / ml, gelatin 18mg / ml, collagen 1mg / ml, hyaluronic acid 5mg / ml, glycerin 50mg / ml, FGF 10ng / ml; the hydrogel composition of the subcutaneous tissue layer includes sodium alginate 15mg / ml, gelatin 25mg / ml, collagen 1mg / ml, hyaluronic acid 1mg / ml, VEGF 0.1ng / ml.

[0065] The preparation method of the hydrogel of the epidermis, the hydrogel of the dermis, and the hydrogel of the subcutaneous tissue layer is the same as that of Example 1.

[0066] The 3D printing method of described a kind of biological 3D printing skin rep...

Embodiment 3

[0072] A biological 3D printing skin repair scaffold, comprising an epidermis layer, a dermis layer and a subcutaneous tissue layer successively superimposed in the form of hydrogel;

[0073] The hydrogel composition of the epidermal layer includes sodium alginate 25mg / ml, gelatin 15mg / ml, collagen 15mg / ml, hyaluronic acid 3mg / ml, elastin 5mg / ml, laminin 5mg / ml, glycerol 100mg / ml, EGF 10ng / ml; the hydrogel composition of the dermis includes sodium alginate 20mg / ml, gelatin 20mg / ml, collagen 10mg / ml, glycerin 80mg / ml, hyaluronic acid 2mg / ml, FGF 20ng / ml; the hydrogel composition of the subcutaneous tissue layer includes sodium alginate 18mg / ml, gelatin 15mg / ml, collagen 10mg / ml, hyaluronic acid 1mg / ml, VEGF 1.0ng / ml.

[0074] The preparation method of the hydrogel of the epidermis, the hydrogel of the dermis, and the hydrogel of the subcutaneous tissue layer is the same as that of Example 1.

[0075]The 3D printing method of described a kind of biological 3D printing skin re...

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Abstract

The invention relates to a biological 3D printing skin repair stent. The biological 3D printing skin repair stent comprises epidermal layers, dermis layers and subcutaneous tissue layers which are sequentially stacked in a hydrogel form, The hydrogel is prepared from sodium alginate, gelatin, collagen, hyaluronic acid, elastin, laminin, glycerol and the like. The skin repair stent further comprises a compact layer used for water locking and barrier. The skin repair stent is subjected to biological 3D printing according to a set 3D printing skin repair stent structure, and the designed skin repair stent structure comprises 2-6 epidermis layers, 6-20 dermis layers and 6-20 subcutaneous tissue layers. The fiber directions of the adjacent layers of the 3D printing layers are orthogonally printed, and the fiber directions of the spacer layers are printed in a staggered mode. According to the skin repair stent, through different hydrogel composition ratios of all the layers, the skin structure is well simulated, and skin repair is effectively promoted.

Description

technical field [0001] The invention relates to the field of skin repair brackets, in particular to a biological 3D printed skin repair bracket. Background technique [0002] The skin wraps the body surface and is in direct contact with the external environment. It has the functions of protection, excretion, temperature regulation, and sensing of external stimuli. It is the largest organ of the human body. The skin is in direct contact with the external environment, so it is extremely vulnerable, such as burns and skin ulcers. When the skin is severely damaged, a suitable wound repair material is needed to promote wound healing. [0003] Wound repair materials include medical dressings, such as gauze, fiber dressings, hydrocolloid dressings, alginate dressings, etc., which can resist external stimulation and infection, prevent dryness and loss of body fluids, and promote wound healing. In addition, skin repair scaffolds also have good development prospects as wound repair m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/20A61L27/22A61L27/24A61L27/52A61L27/54B33Y70/10B33Y80/00
CPCA61L27/20A61L27/222A61L27/227A61L27/24A61L27/52A61L27/54A61L27/60A61L2300/414A61L2430/34B33Y80/00B33Y70/10C08L5/04C08L5/08C08L89/00
Inventor 牛长梅赵伟新杨熙施毕旻邵新宇孙炳伟郭在文季冬东周晨
Owner NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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