Method for preparing three-dimensional metal microneedle array by directly utilizing razor blade

Abstract

The invention relates to a method for preparing a three-dimensional metal microneedle array by directly utilizing a razor blade. Firstly, double-sided razor blades serve as a microneedle preparing blank, a clamping tool is machined, and the blades are alternately stacked in a groove of the clamping tool; secondly, the blades are cut according to the shape and the size of the microneedle array, half-sheet type or whole-sheet type microneedle sheets are obtained, and the machined microneedle sheets are taken out for later use; and thirdly, a three-dimensional microneedle array packaging fixtureis designed and machined according to the packaging of the half-sheet type microneedle array and the whole-sheet type microneedle array, the microneedle sheets and gaskets are put into a packaging structure alternately, and fastening is carried out through bolts to obtain the three-dimensional microneedle array. According to the method, structural characteristics of a conventional razor blade arefully utilized, manufacturing procedures are few, cost is low, efficiency is high, a needle tip is sharp, and the method is suitable for large-batch manufacturing; according to the designed machiningtool, the blades are alternately stacked on cutting edge parts, gaps between the blades are reduced as much as possible, and the machining precision is improved; and the matched packaging structure issimple to use, convenient to carry, detachable to clean and disinfect and reusable.

Description

technical field [0001] The invention belongs to the technical field of medical equipment and the field of mechanical processing, and relates to a three-dimensional metal microneedle array and a preparation method thereof. Background technique [0002] Oral administration, injection administration and transdermal administration are the three most commonly used administration methods at present, and each of these three delivery methods has advantages and disadvantages. For example, oral administration is very convenient to store, carry and use, but because the drug needs to pass through tissues and organs such as the gastrointestinal tract and liver, intestinal inactivation and the "first-pass effect" of the liver will cause part of the drug to be metabolized, and the absorption efficiency is greatly reduced. However, some drugs may cause side effects such as adverse stimulation to the stomach, thereby limiting the scope of application of oral administration, especially not su...

AI Technical Summary

Problems solved by technology

At present, metal microneedle processing methods are quite rich, including chemical etching, ultraviolet lithography, micro-milling, laser cutting, electroplating, etc., but these processing methods have the disadvantages of low processing accuracy, low processing efficiency and high cost, and it is difficult to meet the requirements of mass production. Production requirements

Our team once proposed a design and preparation method of a planar metal microneedle array based on wire cutting, which has the advantages of high efficiency, simple preparation, low cost, and controllable precision, and is suitable for mass production. However, the microneedles are cut from thin metal sheets. Therefore, the size along the thickness direction remains unchanged, and the needle tip can only be sharpened by changes in the width direction, which affects the overall sharpness of the microneedle tip, resulting in a relatively large force when the microneedle penetrates the skin, which is not conducive to full use. The advantages of microneedling are painless and minimally invasive

In addition, since the metal flakes used as raw materials are often large-sized, they need to be processed into small-sized flakes before use, which increases the process and cost

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