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External gel for skin wounds, and preparation method of external gel

A technology for external use of gels and skin wounds, which is applied in the directions of skin diseases, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Use effect, poor stability of active ingredients, etc., to achieve the effect of simple preparation method, reduced wound healing days, good stability and uniformity

Active Publication Date: 2020-12-25
SHANDONG RUIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the pharmaceutical preparations for the treatment of skin wounds are ointments, and their auxiliary ingredients are mainly vaseline and liquid paraffin. In the case of high temperature (> 38 ℃), vaseline will gradually dissolve, and the granular dispersed solids will appear to settle, which will affect the uniformity and use effect of the ointment

Method used

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  • External gel for skin wounds, and preparation method of external gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: the preparation of the external gel for skin wound

[0047] 1. Composition of raw materials (by weight):

[0048] 2 parts of active component A, 5 parts of active component B, 12 parts of calendula extract, 18 parts of centella asiatica extract, 63 parts of excipients; of which:

[0049] The active component A is formed by mixing polymyxin B sulfate, neomycin sulfate and bacitracin in a mass ratio of 0.65:5.36:7.7; the polymyxin B sulfate is 50000 units / branch, and the Neomycin sulfate is 35000 units / support, and the bacitracin is 5000 units / support.

[0050]The active component B is formed by mixing lidocaine hydrochloride and menthol at a mass ratio of 1:1.

[0051] The calendula extract is prepared by the following method:

[0052] Dry and pulverize Calendula officinalis, extract 3 times with 10 times by weight of ethanol with a volume concentration of 95%, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are...

Embodiment 2

[0062] Embodiment 2: the preparation of the external gel for skin wound

[0063] 1. Composition of raw materials (by weight):

[0064] 1 part of active component A, 6 parts of active component B, 10 parts of calendula extract, 20 parts of centella asiatica extract, 60 parts of excipients; including:

[0065] The active component A is mixed by polymyxin B sulfate and neomycin sulfate in a mass ratio of 0.65:5.36; the polymyxin B sulfate is 50000 units / support, and the neomycin sulfate is 35000 units / piece.

[0066] The active component B is pramoxine hydrochloride.

[0067] The calendula extract is prepared by the following method:

[0068] Dry and pulverize Calendula officinalis, extract 4 times with 8 weight times of ethanol with a volume concentration of 95%, the extraction temperature is 70°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 -1.2 (measured at 50°C), to obtain alcoholic ex...

Embodiment 3

[0076] Embodiment 3: the preparation of the external gel for skin wound

[0077] 1. Composition of raw materials (by weight):

[0078] 3 parts of active component A, 4 parts of active component B, 14 parts of calendula extract, 16 parts of centella asiatica extract, 60 parts of excipients; of which:

[0079] The active component A is formed by mixing neomycin sulfate and bacitracin at a mass ratio of 5.36:7.7; the neomycin sulfate is 35,000 units per branch, and the bacitracin is 5,000 units per branch.

[0080] The active component B is formed by mixing procaine hydrochloride and menthol at a mass ratio of 1:1.

[0081] The calendula extract is prepared by the following method:

[0082] Dry and pulverize Calendula officinalis, extract twice with 95% ethanol with a volume concentration of 9 times the weight, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 ...

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Abstract

The invention discloses an external gel for skin wounds. The external gel is prepared from the following raw materials in parts by weight: 1-3 parts of an active component A, 4-6 parts of an active component B, 10-14 parts of a Calendula arvensis extract, 16-20 parts of a Centella asiatica extract, and 60-80 parts of an auxiliary material, wherein the active component A is at least two of polymyxin B sulfate, neomycin sulfate and bacitracin, the active component B is at least one of lidocaine hydrochloride, pramoxine hydrochloride, procaine hydrochloride and menthol, and the auxiliary materialcomprises the following raw materials in parts by weight: 0.5-3 parts of carbomer, 40-75 parts of an organic solvent, and 20-50 parts of purified water. The external gel provided by the invention hasprevention and treatment effects on the bacterial infection of skin wound parts, has analgesic and hemostatic effects on skin wounds, can promote the formation of capillaries and collagenous fibers of wound surfaces, reduces the healing days of wound surfaces, and can be used for the healing of skin wounds such as burn wounds, incised wounds and scald wounds, the healed skin is smooth and free ofscars, and thereby the healing effect is good.

Description

[0001] 1. Technical field [0002] The invention relates to the technical field of pharmaceutical preparations, in particular to an external gel for skin wounds and a preparation method thereof. [0003] 2. Background technology [0004] Skin is an important organ of the human body, composed of epidermis and dermis, and has important physical, chemical and biological barrier functions. Burns, cuts, and scalds are common skin wounds in peacetime and wartime; various damages caused by skin trauma, such as: increased metabolism, decreased body temperature, excessive loss of water and protein, and disorders of the endocrine and immune systems are all related to the skin barrier. related to loss of function. [0005] Wound healing is a complex biological process, including cell proliferation, differentiation, epithelialization, migration, and matrix synthesis and deposition. In clinical practice, skin wounds are often treated by speeding up wound healing, preventing bacterial infe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/06A61K47/10A61P17/02A61P31/02A61P31/04A61K31/7036A61K31/167A61K31/535A61K31/245A61K31/045A61K36/28
CPCA61K9/0014A61K9/06A61K31/045A61K31/167A61K31/245A61K31/535A61K31/7036A61K36/23A61K36/28A61K38/12A61K47/10A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61P17/02A61P31/02A61P31/04A61K2300/00
Inventor 张焕刘宗银钱林艺曹慧敏
Owner SHANDONG RUIAN PHARMA CO LTD
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